The Comparison of Platelet‐Rich Plasma Versus Injectable Platelet Rich Fibrin in Facial Skin Rejuvenation

Abstract

Background/Objective. Platelet-rich plasma (PRP) has a widespread use in various indications including dermatological conditions. Injectable platelet-rich fibrin on the other hand is prepared without anticoagulants and seems to have a sustained action. This study aimed to compare PRP and PRF injection treatments for facial skin rejuvenation in terms of efficacy, patient satisfaction, and side effects. Patients and Methods. Patients who received facial intradermal injections of PRP or PRF for skin rejuvenation were included in this study. Patients received three injections one month apart and evaluated at follow-up visits for cosmetic results using a high-resolution UVA-light video camera and a surface evaluation software at three regions (frontal, nasolabial, and canthal) as well as for patient satisfaction and side effects. Results. A significant marginal superiority of PRF over PRP was only evident for some canthal cosmetic parameters (canthal smoothness and wrinkles); however, the two groups did not differ in terms of other cosmetic regional parameters. For canthal smoothness, the difference was significant at three months. The two groups did not differ in terms of side effects, pain, and patient satisfaction. Conclusion. This study obtained slightly better outcomes with PRF injections when compared to PRP for facial rejuvenation only at canthal region and only at three months, which disappeared later during the treatment. PRF may represent a viable alternative to PRP for that indication owing to its easier preparation, absence of anticoagulants, and possibly its sustained effect. Further large studies are warranted.

Effectiveness of Injectable Platelet-Rich Fibrin Therapy in Alopecia and Facial Rejuvenation: A Systematic Review

“…Atsu N et al [17] and Vesala AM et al [11] demonstrated significant enhancements in skin texture and elasticity and reduced fine lines and wrinkles. These studies suggest that the benefits of PRF extend beyond simple tissue repair; PRF acts as a natural filler by promoting the synthesis of collagen and facilitating tissue regeneration.…”

“…Comparative analyses, particularly the study by Atsu N et al [17], revealed nuanced findings when PRF is juxtaposed with other regenerative therapies, such as platelet-rich plasma (PRP). While both treatments are derived from autologous blood and share some mechanisms of action, PRF has shown superior outcomes in specific esthetic parameters such as canthal smoothness and wrinkle reduction.…”

The Biological Role of Platelet Derivatives in Regenerative Aesthetics

“…These factors contribute to decreased or hyperexpression in melanocytes, reduced fibroblast activity, and diminished collagen and elastin synthesis, leading to dermal disruption and the dysregulation of the stem cell population responsible for tissue repair [ 60 , 61 ]. Subsequent skin changes involve hyper- or hypopigmentation, skin laxity, and the development of both superficial and deep wrinkles, significantly impacting self-image and social acceptance [ 62 ]. Regarding rejuvenation, the primary goal is to counteract or minimize the aging process using either surgical or noninvasive methods.…”

“…As the demand for aesthetic procedures to prevent related changes and enhance skin quality has risen, there has been a notable decline in the number of patients opting for surgical interventions [ 61 ]. Among the nonsurgical aesthetic procedures, PRP has been extensively researched and has yielded favorable results with high patient satisfaction and no significant adverse effects [ 62 ]. PRP offers numerous benefits in facial rejuvenation, addressing concerns such as atrophic acne scars, pigmentation disorders, wrinkles, folds, loss of elasticity, and tissue volume loss.…”