The comparison of microdose flare up and flexible antagonist protocols in poor responders undergoing IVF treatment: A prospective randomized controlled trial

Özdoğan, Serdinç; Özdeğirmenci, Özlem; Dilbaz, Serdar; Demır, Berfu; Çinar, Özgür; Dilbaz, Berna; Göktolga, Ümit

doi:10.28982/josam.432629

Cited by 1 publication

(2 citation statements)

References 24 publications

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“…In another study, Özdoğan et al showed that the PR was non-significantly more in micro-dose protocol while the days of stimulations and a total dosage of gonadotropins were non-significantly more in the antagonist group (21). Moreover, Kahraman et al found that the clinical PR was non-significantly more elevated in the micro-dose group (22).…”

Section: Discussionmentioning

confidence: 98%

“…Studies comparing the micro-dose regimen with the antagonist regimen in treating women with a reduced response (18)(19)(20)(21)(22)(23) are relatively less in comparison to those comparing the antagonist with agonist flare-up protocol in POR women undergoing ICSE-ET (24)(25)(26)(27)(28)(29)(30). Furthermore, there is still a debate on the effectiveness of these three protocols.…”

Section: Discussionmentioning

confidence: 99%

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A Comparison of 3 Different Controlled Ovarian Stimulation Protocols in Poor Women Responders Chosen According to POSEIDON Criteria: Micro-dose, Standard Flare-up, and Antagonist Protocol

Al-Jeborry

Alizzi

Al-Anbari

2019

International Journal of Women’s Health and Reproduction Scienc

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Objectives: To compare the effectiveness and outcomes of pregnancy accomplished by in vitro fertilization between micro-dose and standard flare-up, along with antagonist protocols in the treatment of poor responders using POSEIDON (Patient-Oriented Strategies Encompassing Individualized Oocyte Number) criteria for diagnosis. Materials and Methods: This prospective study included 114 poor responder Iraqi women undergoing intracytoplasmic sperm injection (ICSI) cycles, who were randomly allocated to 3 groups according to the treatment protocol. Micro-dose (n=38), standard flare-up (n=38) and antagonist (n=38) protocols. High dose gonadotrophins (300-450 IU/day) from day 2 of the cycle until the day of human chorionic gonadotropin (hCG) administration were used in the three groups. The primary outcome measure was the number of retrieved mature oocytes and the secondary outcomes included fertilization, implantation, and pregnancy rates (PRs). Results: The estradiol level at the day of hCG trigger was higher in women who received a standard flare-up protocol while there was a higher endometrial thickness in the micro-dose group compared to standard flare-up and antagonist groups (P<0.05). In addition, non-statistically significantly higher fertilization, implantation, and PRs with less cancellation rates were observed in the micro-dose group. Conclusions: The micro-dose protocol in the poor responder improved pregnancy, fertilization, and implantation rates while reducing the cancellation rate compared to standard flare-up and antagonist protocols although the result represented no statistical significance.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

A Comparison of 3 Different Controlled Ovarian Stimulation Protocols in Poor Women Responders Chosen According to POSEIDON Criteria: Micro-dose, Standard Flare-up, and Antagonist Protocol

Al-Jeborry

Alizzi

Al-Anbari

2019

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

show abstract

The comparison of microdose flare up and flexible antagonist protocols in poor responders undergoing IVF treatment: A prospective randomized controlled trial

Abstract: How to cite / Atıf için: Özdoğan S, Özdeğirmenci Ö, Dilbaz S, Demir B, Çınar Ö, Dilbaz B, Göktolga Ü. The comparison of microdose flare up and flexible antagonist protocols in poor responders undergoing IVF treatment: A prospective randomized controlled trial.

Cited by 1 publication

References 24 publications

A Comparison of 3 Different Controlled Ovarian Stimulation Protocols in Poor Women Responders Chosen According to POSEIDON Criteria: Micro-dose, Standard Flare-up, and Antagonist Protocol

A Comparison of 3 Different Controlled Ovarian Stimulation Protocols in Poor Women Responders Chosen According to POSEIDON Criteria: Micro-dose, Standard Flare-up, and Antagonist Protocol

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