The Comparison of Clinical and Histopathological Effects of Topical Psyllium (Plantago ovata) Powder and Silver Sul-fadiazine on Second-Degree Burn Wound Healing in Rats

Abstract

BACKGROUND Burn wounds are a worldwide health problem, leading to physical and psychological disabilities in all age’s groups. With regard to absorbent properties of Plantago ovata mucilage which can decrease wound moisture, we aimed to compare the effect of silver sulfadiazine (SSD) 1% and powdered P. ovata on second-degree burn wound healing in rats. METHODS This experimental study was conducted on 30 male Wistar rats with second-degree burn in three groups. Group 1 (control) did not receive any treatment; group 2 and group 3 (treated groups) were dressed daily using SSD cream and P. ovata powder, respectively. The weight of rats, wound size (by applying ImageJ software) and percentage of wound healing on the 5 th , 7 th , 10 th , 13 th , 16 th , 19 th , and 22 nd days (by diagnosing a plastic surgeon) and histological cutaneous changes at day 22 were evaluated. The Prism software was applied for data analysis. The Haematoxylin & Eosin as well as Masson's trichrome staining were performed on wound skin biopsies. RESULTS On day 22 nd , 20%, 50% and 60% of the rats had complete wound healing in the control, SSD and P. ovat a groups, respectively. A significant decrease in wound size was shown in the treated groups compared to the control group ( P <0.01), but no significant difference was shown between the treated groups ( P >0.05). CONCLUSION However, the wound healing in P. ovata group or SSD was better than the control group, and the significant difference was not found with the treated group.

New approaches to second-degree burn healing: Polyvinyl alcohol membrane loaded to arnica combined to laser therapy

“…In the histological analysis with Masson’s Trichrome staining (MT), it was observed that in all treated groups a marked presence of collagen was identified, but only the group treated PVA+A+L 14 days was significantly different from the control (Table 4; Figure 8), showing that this treatment was more efficient in this experimental design, similar to the findings of 39 in histopathological studies of scar tissue from 2nd degree burns treated with Plantago ovata and silver sulfadiazine. In this line, many studies seeking treatment for skin lesions caused by burns use herbal medicines such as Aloe vera and suggest that this herbal medicine stimulates fibroblasts and, in turn, collagen in the granulation tissue.…”

To compare the effect of sea buckthorn and silver sulfadiazine dressing on period of wound healing in patients with second‐degree burns: A randomized triple‐blind clinical trial

“…15,16 While extensive research has been conducted into identifying the efficacy of sea buckthorn in wound healing in non-human samples, [17][18][19] rare research programs examining the effect of sea buckthorn in burns of human samples have been carried out. 20 Thus, considering SSD is the most common and the main medicine used in routine treatment of burn wounds in our country Iran, 21 researchers of the present study designed this controlled clinical trial aiming at evaluating the period of wound healing with sea buckthorn topical cream dressings for the second-degree burns and comparing the results with the 1% SSD dressings.…”