The comparison of CD4/CD8 ratio among high and ordinary background radiation areas in Ramsar, Iran

The effective radiation dose of human from natural sources is about 2.4 mSv/y and the dose limit for radiation workers is 20 mSv/y. Ramsar, a city in Iran, has been the subject of concern in the last forty years for a high level of radiation measured in some spots as high as 260 mSv/y. Carcinogenesis is one of the most studied effects of radiation especially in high doses. Recent studies showed that the high level of natural radiation received by inhabitants of this area, paradoxically don’t have significant health effect. Natural killer (NK) cells and cytotoxic T cells are the most important cells in tumor immune surveillance and CD107a is a widely expressed intracellular protein located in the lysosomal/endosomal membrane. CD107a transiently located on the cell membrane can be used as a marker of CD8 + T cell degranulation following stimulation. It is also expressed, to a lower extent, on activated NK cells. In this study, 60 healthy people were selected randomly and their consent obtained and confounding factors such as sex, age, life-styles was matched then the count of activated NK and CD8 + cells was compared in high and normal background radiation areas inhabitants of Ramsar. After filling the questionnaire and measurement of background radiation, blood samples of 30 healthy people from each region were analyzed immediately by means of flowcytometry. The leukocytes and their subsets were not significantly different between two groups and the count of active cells was higher in control group. The result shows that the changes in immune system occur due to radiation and maybe it is as a result of higher radiosensitivity of activated cells.

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“…But the absolute counts of CD4 + and CD8 + and CD4+/CD8 + ratio was not significantly different between HBRA and NBRA residents of Ramsar. [27]…”

Section: Discussionmentioning

confidence: 99%

The assessment of cytotoxic T cell and natural killer cells activity in residents of high and ordinary background radiation areas of Ramsar-Iran

Borzoueisileh¹,

Monfared²,

Abediankenari³

et al. 2013

J Med Phys

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“…showed that the increase in CD4+% and CD8+% in the HBRA group and other measurements were not significantly different between HBRA and ordinary background radiation area (OBRA) residents of Ramsar. [4]…”

Section: Discussionmentioning

confidence: 99%

“…The average and maximum annual effective doses of the inhabitants of Ramsar are 10.2 and 260 mSv, respectively. [4] The radiation effective doses of Ramsar inhabitants are mainly due to Ra-226 and its decay products. [4] In addition, the concentrations of natural radionuclides in food and drinking water of the residents are higher than the world average, and are correlated with the high concentration of these radionuclides in soil and water.…”

Section: Introductionmentioning

confidence: 99%

“…[4] The radiation effective doses of Ramsar inhabitants are mainly due to Ra-226 and its decay products. [4] In addition, the concentrations of natural radionuclides in food and drinking water of the residents are higher than the world average, and are correlated with the high concentration of these radionuclides in soil and water. [2] Studies of inhabitants of high background radiation areas (HBRAs) are very useful in predicting disease risks from chronic radiation exposures in nuclear and medical workers and in other exposed populations.…”

Section: Introductionmentioning

confidence: 99%

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The effects of residence duration in high background radiation areas on immune surveillance

et al. 2013

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Purpose:The effective dose received by humans from natural sources is about 2.4 mSv y-1, but this is 10.2 mSv y-1 for inhabitants of Ramsar, a city in northern Iran. Carcinogenesis is one of the most studied effects of radiation, especially in high doses. Nonetheless carcinogenesis of low doses is uncertain. A recent epidemiological study in high background radiation areas of Ramsar showed that the cancer incidence in this era is lower than neighbors. The reason of this different behavior is under study yet. NK cells, helper, and Cytotoxic T cells are most important components of the tumor immune surveillance. The counts and activities of these cells and also leukocytes, lymphocyte, neutrophil cells, and other important parameters were studied in the residents of Ramsar with different duration of exposure to chronic low dose radiation.Materials and Methods:Fifty residents of high background radiation areas, who were between 25 and 35 years and fully healthy, were selected randomly and their consent was obtained. Then, 2 cc fresh peripheral bloods were taken in sterile conditions. Complete blood cell counts were performed by an automatic hematology analyzer and CD4+, CD8+, NK, and CD107a+ cell counts were determined by monoclonal antibodies and flowcytometry. CD4+ and CD8+ percentages and the CD4/CD8 ratio were determined and the data were analyzed using SPSS 16.Results:The percentages of CD4+ cells increase, but the counts of CD107a+ cells decline in higher exposure durations. The other parameters did not have significant regression with exposure duration.Conclusions:These confirm that living in high background radiation areas may induce changes in the immune system gradually and address more investigations.

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“…[ 11 12 13 ] Some studies have linked this phenomenon to repair mechanisms, immune system, and molecular pathways. [ 14 15 16 ]…”

Section: Introductionmentioning

confidence: 99%

Radio-adaptive response in myocardial perfusion imaging induced by technetium-99m

et al. 2017

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Purpose of the Study:Low dose radiation will induce adaptation and following exposure to an adaptive dose, the cells are more resistance to following challenging doses. This phenomenon is known as radio-adaptive response. The aim of this study was to investigate the percentage of apoptotic cells in the peripheral blood samples of the patients which undergo myocardial perfusion imaging (MPI) with technetium-99m (Tc-99m) before thallium scan to assess the induction of radio-adaptive response.Materials and Methods:In this study, 97 samples from 74 patients, referred to nuclear medicine center of Mazandaran Heart Hospital for MPI, which had no history of diagnostic, therapeutic, occupational, and radioactive exposures during past 2 years, were provided. The participants were classified into four groups including control, patients which were scanned solely with technetium, the patients which examined by thallium and the last group were the patients that examined by technetium followed by thallium. Then 2 ml Peripheral blood samples were obtained, and after 24 h incubating, the samples were studied by neutral comet assay. Statistical analysis was carried out using Student's t-test along with one-way analysis of variance.Results:The mean percentage of apoptotic cells in the exposed groups were higher than the control. Furthermore, among exposed groups, the apoptotic cells in thallium group were more than others and this index was significantly lower in the group which was undergone technetium administration before thallium scan.Conclusions:These findings suggest that exposure to Tc-99m could induce a radio-adaptive response against the exposure of thallium-201.

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The comparison of CD4/CD8 ratio among high and ordinary background radiation areas in Ramsar, Iran

Cited by 7 publications

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The assessment of cytotoxic T cell and natural killer cells activity in residents of high and ordinary background radiation areas of Ramsar-Iran

The assessment of cytotoxic T cell and natural killer cells activity in residents of high and ordinary background radiation areas of Ramsar-Iran

The effects of residence duration in high background radiation areas on immune surveillance

Radio-adaptive response in myocardial perfusion imaging induced by technetium-99m

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