The Comparison of Angiographic Scoring Systems With the Predictors of Atherosclerosis

Kalkan, Kamuran; Hamur, Hikmet; Yıldırım, Erkan; İpek, Emrah; Ermis, Emrah; Öztürk, Mustafa; Karal, Hüseyin; Korkmaz, Ali Fuat; Bayantemur, Murat; Demirelli, Selami

doi:10.1177/0003319717712118

Cited by 13 publications

(13 citation statements)

References 26 publications

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“…Previous studies also reported this correlation between carotid DUS results and the severity of coronary artery disease . Kalkan et al also showed that SXscore is significantly associated with carotid DUS findings, such as carotid intima‐media thickness. However, Avci et al favored that the Gensini score is well associated more with the severity of carotid disease than SXscore.…”

Section: Discussionmentioning

confidence: 63%

The role of SYNTAX score in decision‐making for preoperative carotid artery screening in patients undergoing coronary artery bypass surgery

et al. 2019

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Background The coexistence of coronary artery disease (CAD) in patients undergoing coronary artery bypass surgery (CABG) is a risk factor for stroke and death. The aim of this study is to evaluate the potential of the SYNTAX score (SXscore) for predicting carotid stenosis in patients undergoing CABG. Methods We retrospectively reviewed 291 patients (225 males, mean age 60.5 ± 8.5 years) who underwent CABG in a single center in 2014 and were screened for carotid artery preoperatively. The total SXscore was obtained by scoring every luminal narrowing greater than 50% in coronary vessels larger than 1.5 mm using the SXscore algorithm. Correlations between the severity of carotid stenosis and SXscore were analyzed. Results As the degree of carotid artery stenosis increases (≤%50; ≥%50 vs ≥%70), the mean SXscore (19.06 ± 7.72, P > 0,05; 28.40 ± 6.89, P < 0,01; 31.02 ± 7.04, P < 0.01, respectively) were found to increase. Receiver operating characteristic analysis revealed a cut‐off point of 27 or more in SXscore according to the presence of carotid stenosis greater than or equal to %70. The risk of existence of significant carotid stenosis was 58‐fold greater in cases with SXscore greater than or equal to 27. In cases with SXscore greater than or equal to 27, the risk of existence of significant carotid stenosis was 58‐fold greater with a confidence interval of 95%. Moreover, the presence of left main CAD was associated with the severity of carotid stenosis (<50% carotid stenosis, P > 0.05; ≥%50, P = 0.001; and ≥70, P = 0.001). Conclusion This study suggests that the presence of left main coronary artery disease or SXscore greater than or equal to 27 should require preoperative carotid screening in patients undergoing CABG, regardless of the presence of risk factors.

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Section: Discussionmentioning

confidence: 63%

The role of SYNTAX score in decision‐making for preoperative carotid artery screening in patients undergoing coronary artery bypass surgery

et al. 2019

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“…In patients with complex carotid plaques, complex coronary artery stenosis co-exists and the degree of the stenosis detected during the carotid artery Doppler examination and the stage of coronary artery disease correlate significantly [14][15][16][17]. Additionally, the SYNTAX score and intima-media thickness of carotid artery correlate significantly [18]. Akansel et al…”

Section: Discussionmentioning

confidence: 99%

Carotid artery stenosis in asymptomatic patients undergoing coronary artery bypass grafting: who and when should be screened?

Özyalçın¹,

Diken²,

Yalçınkaya³

et al. 2021

Kardiol Pol

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“…The severity of coronary atherosclerosis is a key factor affecting the outcome of CAD. Currently, the severity and complexity of the obstructive coronary lesions in the clinic are often aggravated by the number of diseased vessels, as well as by various scoring systems (33). SYNTAX score is one of the quantitative tools used to measure the complexity of coronary artery lesions, as well as to guide optimal revascularization therapy in the clinic (34).…”

Section: Discussionmentioning

confidence: 99%

Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis

Zheng

Peng

et al. 2019

Int J Mol Med

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The senescence of vascular endothelial cells (ECs) plays a critical role in aging-related cardiovascular diseases. We previously reported the causal relation of Jagged1 in ECs and the thickening of the arterial wall in aging mice. The aim of the present study was to further investigate the correlation between insulin-like growth factor-binding protein 1 (IGFBP1), one of the secretory proteins regulated by Jagged1, and the severity of coronary atherosclerosis and patient age, as well as its effect on EC senescence. First, microarray analysis was performed to screen the differentially expressed genes regulated by Jagged1 in human coronary arterial ECs (HCAECs). Inhibition of the Jagged1 expression using a small interfering RNA knockdown method in HCAECs led to the upregulation of 17 and the downregulation of 78 genes by >3-fold, and IGFBP1 was confirmed to be a secretory protein expressed by HCAECs and regulated by Jagged1. Subsequently, in 112 consecutively enrolled patients with acute chest pain who underwent coronary angiography, the circulating level of IGFBP1 was found to be positively correlated with age (r=0.512, P<0.001) and Synergy between PCI with TAXUS and Cardiac Surgery (SYNTAX) score (r=0.409, P<0.001). Among age-comparable patients, the circulating IGFBP1 level was found to be increased in patients with higher SYNTAX scores. In cultured HCAECs, IGFBP1 was shown to protect ECs against passage- or H2O2-induced senescence, and these protective effects of IGFBP1 may be partially reversed by LY294002, a known Akt signaling inhibitor. Therefore, the results of the present study suggested that, as a downstream protein of Jagged1, IGFBP1 was correlated with the severity of coronary atherosclerosis in aging patients, and the increase of circulating IGFBP1 levels with aging may be an adaptive response to counter HCAEC senescence through Akt signaling.

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The Comparison of Angiographic Scoring Systems With the Predictors of Atherosclerosis

Cited by 13 publications

References 26 publications

The role of SYNTAX score in decision‐making for preoperative carotid artery screening in patients undergoing coronary artery bypass surgery

The role of SYNTAX score in decision‐making for preoperative carotid artery screening in patients undergoing coronary artery bypass surgery

Carotid artery stenosis in asymptomatic patients undergoing coronary artery bypass grafting: who and when should be screened?

Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis

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