The comparison between curcumin and propolis against sepsis-induced oxidative stress, inflammation, and apoptosis in kidney of adult male rat

Abstract

Background Propolis is a honeybee product displaying an anti-inflammatory, antimicrobial, and antioxidant effect on several tested animal models. Curcumin a polyphenol extracted from turmeric that gained interest as a potentially safe and inexpensive treatment for kidney diseases. The present study aimed to compare the protective effects of curcumin and propolis on endotoxemia-induced renal dysfunction. Results Sepsis induction caused a marked decline in renal GSH, GPx, and GR, as well as antioxidant enzyme activities; CAT and SOD. Elevation in LPO, NO, IL-1β, and PGE2 contents were observed as well. A marked induction in Bax contents, Bax\Bcl2 ratio, accompanied by activation of NF-kB in the kidney of sepsis-induced rats was reported. However, Prop pretreatment of endotoxemic rats was effective in controlling the depletion of renal GSH content and its correlated enzymes; Cur was more potent in maintaining the renal CAT and SOD contents, as well as, dimensioning LPO content. Despite the renal inflammatory marker IL-1β, PGE2, NO contents, Bax\Bcl2 ratio, and NF-kB activation were greatly reduced by both curcumin and propolis, only Cur pretreatment attenuated NF-kB activation in kidney tissue of septic rat. Conclusion Though pretreatment of either Cur or Prop to septic rats protected their kidneys against oxidation, inflammation, and apoptosis status, Cur pretreatment was superior in protecting rats’ kidney after sepsis induction.

Assessment of the Effect of Propolis Extract on Enzymatic Antioxidants and Lipidperoxidation

“…Forms (1,2,3,4) show a significant significance of (p≤0.05) in the activity of antioxidants in the tiles with the water extract and the alcohol for the propolis E.E.P when compared to the positive group and this result is compatible with [39], [40] as well as the study of [17] that referred to the role of alcoholic extracts of propolis in the events of a significant increase in the levels of antioxidants such as the SOD and the GPX. The study of [41] and [42] also agreed with the results of our study, which indicated the role of aqueous extract in preventing the damage and toxic effects of oxidative stress by increasing the capacity of antioxidants such as catalase and superoxide dismutase.…”

Emulgels Containing Propolis and Curcumin: The Effect of Type of Vegetable Oil, Poly(Acrylic Acid) and Bioactive Agent on Physicochemical Stability, Mechanical and Rheological Properties

“…It displays an extensive range of biological activities, going from antioxidant, immunostimulant, antimicrobial, anti-inflammatory, and antiviral effects to anticancer activity [36,38,39] to tissue regenerating and healing in ulcers [38,40]. According to Abd-Elrazek and collaborators (2020), PRP can inhibit systemic inflammation, as well as decrease the oxidative stress by protecting the membranes and eliminating free radicals, evidencing its anti-inflammatory and antioxidant activities [41]. This drug is frequently processed as ethanolic extract (PE), which can be used as a final or intermediary dosage form [24,38,42].…”

Recent Update on the Anti-Inflammatory Activities of Propolis

“…Other groups have also confirmed the hepatoprotective capacity of propolis against hepatotoxic compounds through its anti-inflammatory activities by down-regulating and/or inhibiting the expression of NF-κB, COX-2, transforming growth factor β (TGF-β), Bcl-2, and IL-6 [ 120 , 121 , 125 , 129 , 131 ]. Similar protective mechanisms and anti-inflammatory activities of propolis were also observed in the retina, skin, pancreas, spleen, kidneys, ovary, and heart [ 100 , 102 , 104 , 108 , 110 , 112 , 118 , 120 , 128 ].…”