The comparison and evaluation of the miR-16, miR-155 and miR-146a expression pattern in the blood of TB and NSCLC patients: A Research paper

Abolfathi, Hanie; Sheikhpour, Mojgan; Soltani, Bahram Mohammad; Fahimi, Hossein

doi:10.1016/j.genrep.2020.100967

Cited by 7 publications

(4 citation statements)

References 44 publications

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“…Lung cancer is the deadliest of all cancers [ 1 , 2 ]. High resistance to chemotherapy and aggression has increased the need for reliable prognostic assay and effective treatments for the disease.…”

Section: Resultsmentioning

confidence: 99%

“…Lung cancer is cancer that most often begins in the lungs but is sometimes the result of Cancer spreading from adjacent areas. Lung cancer is divided into two groups non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) [ 1 , 2 ]. Risk factors for lung cancer include two groups of genetic and environmental factors, environmental factors such as smoking, asbestos exposure, radon gas, air pollution, and age [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

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A literature review of microRNA and gene signaling pathways involved in the apoptosis pathway of lung cancer

2023

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Background Lung cancer is one of the leading causes of death in the world and the deadliest of all cancers. Apoptosis is a key pathway in regulating the cell growth rate, proliferation, and occurrence of lung cancer. This process is controlled by many molecules, such as microRNAs and their target genes. Therefore, finding new medical approaches such as exploring diagnostic and prognostic biomarkers involved in apoptosis is needed for this disease. In the present study, we aimed to identify key microRNAs and their target genes that could be used in the prognosis and diagnosis of lung cancer. Methods Signaling pathways, genes, and microRNAs involved in the apoptotic pathway were identified by bioinformatics analysis and recent clinical studies. Bioinformatics analysis was performed on databases including NCBI, TargetScan, UALCAN, UCSC, KEGG, miRPathDB, and Enrichr, and clinical studies were extracted from PubMed, web of science, and SCOPUS databases. Results NF-κB, PI3K/AKT, and MAPK pathways play critical roles in the regulation of apoptosis. MiR-146b, 146a, 21, 23a, 135a, 30a, 202, and 181 were identified as the involved microRNAs in the apoptosis signaling pathway, and IRAK1, TRAF6, Bcl-2, PTEN, Akt, PIK3, KRAS, and MAPK1 were classified as the target genes of the mentioned microRNAs respectively. The essential roles of these signaling pathways and miRNAs/target genes were approved through both databases and clinical studies. Moreover, surviving, living, BRUCE, and XIAP was the main inhibitor of apoptosis which act by regulating the apoptosis-involved genes and miRNAs. Conclusion Identifying the abnormal expression and regulation of miRNAs and signaling pathways in apoptosis of lung cancer can represent a novel class of biomarkers that can facilitate the early diagnosis, personalized treatment, and prediction of drug response for lung cancer patients. Therefore, studying the mechanisms of apoptosis including signaling pathways, miRNAs/target genes, and the inhibitors of apoptosis are advantageous for finding the most practical approach and reducing the pathological demonstrations of lung cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A literature review of microRNA and gene signaling pathways involved in the apoptosis pathway of lung cancer

2023

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“…Since studies show that circulating miRNAs play a role as biomarkers in the development of various diseases and serve for the early diagnosis of lung cancer and TB, miR-182 can be used as a diagnostic marker in cancer and in the absence of mutations. MiR-34a can be mentioned as one of the cancer suppressors, and previous studies [ 15 , 34 ] have stated that not only the type of miR is important in the development of disease, but it is very important to know the target genes in the effect of miR in which stage of the cell cycle. Studies show a dual function for miR-182 that it can act as a tumor suppressor miRNA [ 22 ] or oncogenic [ 35 ] in increasing cancer cell proliferation, survival, aggressiveness, tumorigenesis, and drug resistance of different tissues.…”

Section: Discussionmentioning

confidence: 99%

“…cDNAs were taken on gel %2 after extraction. Reverse transcriptase quantitative PCR analysis of miRNAs was performed with cyber Green qPCR Master Mix (Takara, Kusatsu, Japan) and miR-16 was considered as reference gene and internal control [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Bioinformatics Study and Experimental Evaluation of miR-182, and miR-34 Expression Profiles in Tuberculosis and Lung Cancer

Alimardanian,

Soltani,

Irani

et al. 2024

Tuberc Respir Dis

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Background: Lung cancer is one of the most dangerous diseases among cancers and tuberculosis is one of the deadliest infectious diseases in the world. Many studies have mentioned the connection between lung cancer and tuberculosis, and also the microRNAs that play a significant role in the development of these two diseases. This study aims to use different databases to find effective miRNAs and their role on different genes on lung and tuberculosis diseases. Also determining the role of miR-34a and miR-182 in lung cancer and tuberculosis. Methods: Using the GEO database, the influential microRNA databases were studied in two diseases. Finally, regarding bioinformatics results and literature studies, two miR-34a and miR-182 were selected. The role of these microRNAs and their target genes was carefully evaluated using bioinformatics. The expression of microRNAs in the blood plasma of patients with lung cancer and tuberculosis and healthy people were investigated. Results: According to the GEO database, miR-34a and miR-182 are microRNAs that affect tuberculosis and lung cancer. By checking the miRBase, miRcode, Diana, miRDB, galaxy, KEGG databases, the role of these microRNAs on genes and different molecular pathways and their effect on these microRNAs were mentioned. The results of the present study showed that the expression of miR-34a and miR-182 was lower than that of healthy people. The P value amount for miR-182 was <0.0001 and for miR-34a was 0.3380. Conclusion: Reducing the expression pattern of these microRNAs indicates their role in lung cancer and tuberculosis occurrence. Therefore, these microRNAs can be used as a biomarker for prognosis, diagnosis, and treatment methods.

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Diagnostic value of microRNAs in active tuberculosis based on quantitative and enrichment analyses

Yao,

Liu,

et al. 2024

Diagnostic Microbiology and Infectious Disease

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The comparison and evaluation of the miR-16, miR-155 and miR-146a expression pattern in the blood of TB and NSCLC patients: A Research paper

Cited by 7 publications

References 44 publications

A literature review of microRNA and gene signaling pathways involved in the apoptosis pathway of lung cancer

A literature review of microRNA and gene signaling pathways involved in the apoptosis pathway of lung cancer

Bioinformatics Study and Experimental Evaluation of miR-182, and miR-34 Expression Profiles in Tuberculosis and Lung Cancer

Diagnostic value of microRNAs in active tuberculosis based on quantitative and enrichment analyses

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