The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs

Health hazard evaluation report: HETA-88-207-2195, Northwest Incinerator, Philadelphia, Pennsylvania.

“…(5)(6)(7) PCDDs and PCDFs with chlorine at positions 2,3,7, and 8 are particularly toxic. (8)(9)(10) PCDDs and PCDFs are highly toxic in experimental animals when administered acutely, subchronically, or chronically. (10)(11)(12)(13)(14)(15)(16)(17)(18) Toxic effects include severe weight loss, liver necrosis and hypertrophy, skin lesions, immunosuppression, reproductive toxicity, teratogenesis and death.…”

Health hazard evaluation report: HETA-88-0140-2517, Boise Cascade, United Paperworkers International Union, Rumford, Maine.

“…8,9,10 PCDDs and PCDFs with chlorine at positions 2,3,7, and 8 are particularly toxic. 11,12,13 PCDDs and PCDFs are highly toxic in experimental animals when administered acutely, subchronically, or chronically. 14,15,16,17,18,19,20,21 Adverse health effects in experimental animals include severe weight loss, liver necrosis and hypertrophy, skin lesions, immunosuppression, reproductive toxicity, teratogenesis, and death.…”

Health hazard evaluation report: HETA-91-261-2245, Metropolitan Sewer District, Mill Creek Facility, Cincinnati, Ohio.

“…[20][21][22] PCDDs and PCDFs with chlorine at positions 2,3,7, and 8 are particularly toxic. [23][24][25] PCDDs and PCDFs are highly toxic in experimental animals when administered acutely, subchronically, or chronically. [26][27][28][29][30][31][32][33] Toxic effects include severe weight loss, liver necrosis and hypertrophy, skin lesions, immunosuppression, reproductive toxicity, teratogenesis and death.…”