The comparative study of serum iron, copper, and zinc levels between bladder cancer patients and a control group

Mazdak, Hamid; Yazdekhasti, F.; Ahmad, Mansoor; Mirkheshti, Nooshin; Mohammad, Shafieian

doi:10.1007/s11255-009-9583-4

Cited by 82 publications

(60 citation statements)

References 23 publications

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“…[27] Therefore, in patients with low serum levels of Mn, the antioxidant activity in the organs may be reduced and thus, these patients may become susceptible to various diseases. These findings were consistent with those reported by Mazdak et al [18] Mn deficiency leads to numerous disorders in humans such as bone deficiency, joint pain, diabetes, and dysmnesia.…”

Section: Discussionsupporting

confidence: 93%

“…[17] As shown in Table 2, serum levels of Zn were lower in the patient group than in the healthy group. Although these findings were consistent with those reported by Cobanoglu et al (2010), [11] Mazdak et al (2010), [18] and Cebi et al (2010), [10] they contradicted the findings reported for patients with malignant glioma by Arslan et al [19] Although Zn has the ability to stimulate collagen synthesis in osteoblasts and activate alkaline phosphatase, these processes have a crucial role in the mineralization and calcification of bones. [20] Zn deficiency is commonly associated with numerous disorders such as retarded bone growth.…”

Section: Discussionsupporting

confidence: 85%

See 1 more Smart Citation

Investigation of some trace element levels (Zn, Fe, Mn, Mg, Cu, Cd, Co, Pb) in patients with burst fractures

Gezh¹,

Aycan

Demır³

et al. 2017

Ulus Travma Acil Cerrahi Derg

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 85%

Investigation of some trace element levels (Zn, Fe, Mn, Mg, Cu, Cd, Co, Pb) in patients with burst fractures

Gezh¹,

Aycan

Demır³

et al. 2017

Ulus Travma Acil Cerrahi Derg

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“…It is reported that gastric cancer may be caused by reactive oxygen species (ROS), and dietary antioxidants, such as zinc, may protect against this disease (Wu et al, 2004;Mazdak et al, 2010). Superoxide dismutase (SOD) plays a key role in the detoxification of superoxide radicals.2).…”

Section: Introductionmentioning

confidence: 99%

Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

Zhang¹,

Wu²,

Niu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The role of Helicobacter pylori status and serum zinc value in gastric disease patients and healthy controls were investigated. Cases used in this work were 45 gastric cancer patients, 44 with peptic ulcers, 52 suffering gastritis and 64 healthy controls, all diagnosed histologically with the controls undergoing medical checkups. Helicobacter pylori status and serum levels of Zn were determined by 13C-urea breath test and flame atomic absorption spectrophotometer, respectively. Our study showed that Helicobacter pylori infection has no change in gastritis, peptic ulcer and gastric cancer group, on the contrast, serum levels of Zn were significantly reduced in gastritis, peptic ulcer and gastric cancer group, compared with healthy controls, and the higher the Zn levels are, the more increased risk of gastric cancer. Helicobacter pylori infection is a cause of gastritis, peptic ulcers and even gastric cancer, while serum zinc level is an indicator of protection of gastric membranes against damage.

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“…Yapılan çalışmalar göstermiştir ki oksidatif strese bağlı hasarlanmalar kanserin gelişimindeki faktörlerden biri olabilir ve oksidasyonu azaltmak mesane kanserinin oluşumunu engelleyebilir (20). Bu durum antioksidant sistemi oluş-turan enzimlerin yapısında bulunan elementlerin oksidatif hasarın azaltılmasına katkı sağla-yabileceğini ve kansere karşı koruyucu bir etkilerinin olabileceğini düşündürtmektedir (21,22). Çinko oksidan-antioksidan özellikleri olan bir elementtir.…”

Section: Discussionunclassified

The effect of zinc rich diet to the cytokine profile in the Rat Bladder on cigarette smoke exposure

Terzi¹,

Kükner²,

Aydın³

et al. 2015

Turk J Bioch

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Amaç: Sigara içimi akciğer, larinks, özefagus, mide, mesane ve böbrek kanserleri ile kronik hastalıkların sebebidir. Sitokinler, inflamasyonun başlatılması ve sürdürülmesinde önemlidirler. Sigara, çinko eksikliği sebebidir. Çinko, antioksidan olup serbest radikallerin zararlarından hücreleri korur. Çalışmamızda sigara dumanına maruz bırakılarak çinkodan zengin diyet ile beslenen sıçanların mesane dokusundaki TLR 2, TLR 4, Nükleer faktör kappa B, İnterlö-kin 1β ve İnterlökin 10 ekspresyonuna etkisi incelenmesi amaçlanmıştır. Yöntem: Çalışmada 24 adet erişkin erkek Wistar-Albino sıçanlar kullanıldı. Sıçanlar 4 gruba ayrıldı. Birinci grup normal, 2. grup ise çinkodan zengin diyetle beslendi. Üçüncü ve 4. gruplar sigara inhalasyonu yapılan gruplar olup sırasıyla normal ve çinkodan zengin diyetle beslenen gruplardı. Deney sonunda alınan mesane dokuları histolojik olarak değerlendirildi. Kalan doku örnekleri ise Real time polymerase chain reaction yöntemi ile sitokin ekspresyonları gösterilerek değerlendirildi. Bulgular: Çalışmadaki hiçbir grup mesane epitelinde deği-şiklik izlenmemiştir. Sigara verilen grupta sadece düz kas yapılarında tabakalar arasında ödem ve bazı alanlarda yoğun inflamatuar hücreler ile bu alanlarda hemoraji ve konjesyona rastlanılmıştır. Çinkodan zengin diyetle beslenen denekler de ise inflamatuar hücrelere, konjesyona ve ödeme daha az rastlandı. Tüm sıçan gruplarının mesane dokularında sitokin ekspresyonları ikili olarak karşılaştır-malarda sigaraya maruz kalmış sıçanlarda çinko almayan ve çinko alan sıçanlar için NF-κB2 geni için anlamlı farklılık bulundu. Sonuç: Sonuç olarak sigara maruz kalan sıçanlarda çinko kullanımının anlamı bir şekilde NF-κB2 ekpresyonunu artışına neden olması, çinkonun sigaraya bağlı gelişen mesane kanserlerinde kanserli hücre apopitozunu arttıra-rak tedaviye katkı yapabileceğini düşündürmektedir.Objective: Cigarette smoking causes lung, larynx, esophagus, stomach, bladder and kidney cancers and chronic diseases. Cytokines are important in initiating and maintaining inflammation. Smoking is the cause of zinc deficiency. Zinc is an antioxidant and protects cells from free radical damage. In our study, it was aimed to investigate the effect of cigarette smoke exposure on expression of Toll-like receptor 2, Toll-like receptor 4, nuclear factor kappa B, interleukin 1β and interleukin 10 in the bladder tissue of rats fed with zinc rich diet. Method: In this study 24 adult male Wistar-Albino rats were used. The rats were divided into 4 groups. First group was fed with normal diet, the 2nd group was fed with zinc rich diet. Third and 4th groups were exposed to cigarette inhalation and fed with normal and zinc rich diet respectively. The bladder tissues were taken at the end of the experiment and evaluated histologically. The remaining tissue samples were evaluated by the method of Real time polymerase chain reaction to show cytokine expression.

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The comparative study of serum iron, copper, and zinc levels between bladder cancer patients and a control group

Cited by 82 publications

References 23 publications

Investigation of some trace element levels (Zn, Fe, Mn, Mg, Cu, Cd, Co, Pb) in patients with burst fractures

Investigation of some trace element levels (Zn, Fe, Mn, Mg, Cu, Cd, Co, Pb) in patients with burst fractures

Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

The effect of zinc rich diet to the cytokine profile in the Rat Bladder on cigarette smoke exposure

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