The comparative studies on anti-obesity effects of Ephedrae Herba and Cyperi rhizoma in high fat diet fed mice

Abstract

Objectives : This comparative study was to investigate on anti-obesity effects of Ephedrae Herba and Cyperi rhizoma in high fat diet(HFD) fed mice. Methods :Male C57BL/6J mice were fed a normal diet(normal group, N), high fat 45 cal% diet[HFD, control group, C), HFD with Ephedrae Herba(EH group) and Cyperi rhizoma(CR group) extracts fed for 5 weeks. We were observed as follows : changes of body weight, amount of diet intake, weight of total visceral fats, levels of obesity-related hormones and blood lipids. Results :The change of body weight after EH and CR oral administration significantly more decreased in EH group than that of control group. The FFR(Food Efficiency Ratio) was decreased in EH group, but more increased in CR group than that of control group. The weight of periepididymal and perirenal fats were significantly decreased in EH

The Effect of Oral Administration at Herbal Medicines in Animal Models on Obesity: A Review of Animal Study Reports Published in Korea after 2010

“…Body weight, total fat weight, liver weight, TG, HDL, AST, hepatic lipid accumulation, gene expression 2 11) Body weight, gene expression 3 12) Body weight, food intake, (periepididymal, perirenal) adipose tissue weight, adiponectin, leptin, insulin, TC, TG, HDL 4 13) Body weight, food intake, fooe efficiency, liver weight, abdominal fat weight, white adipose tissue weight, TC, TG, HDL, LDL, GOT, GPT, leptin, adiponectin, hepatic content (total lipid, TG), gene expression 5 14) Body weight, liver weight, adipose tissue weight, AST, ALT, TC, TG, AI, HDL, LDL, adiponectin, cell number of adipose tissue 6 15) Body weight, food intake, liver weight, glucose, insulin, TC, HDL, GOT, GPT, size of epididymal adipocyte 7 16) Glucose, OGTT, ATM, gene expression 8 17) Body weight, food intake, food efficiency, adipose tissue weights, adipose tissue size, gene expression 9 18) Body weight, weights of liver and adipose tissue 10 19) Body weight, adipose tissue weights, FER, leptin, TG, glucose, insulin, hepatic lipid accumulation, number and size of (inguinal, epididymal) adipocytes 11 20) Body weight, HDL, LDL 12 21) Body weight, liver and abdominal fat weight, total cholesterol, TG, HDL, LDL, glucose, GOT, GPT 13 22) Body weight, glucose, total cholesterol, LDL 14 23) Body weight, food efficiency, white adipose tissue and liver weight, TG, total cholesterol, LDL, leptin, adiponectin, fat volume, hepatic lipid accumulation, hepatic content (total lipid, TG, total cholesterol), gene expression 15 24) Body weight, food intake, epididymal adipose tissue weight, AST, ALT, TG, total cholesterol, LDL, HDL, leptin, liver tissue 16 25) Free fatty acid, TG, total cholesterol, LDL, HDL, TBARS, IL-1β, IL-6, TNF-α, IL-10, NO, liver content (total cholesterol, TG, TBARS, GSH-Px, SOD, CAT), gene expression 17 26) Body weight, adipose tissue weights, FER, leptin, TG, glucose, insulin, cell number and size of (inguinal, epididymal) adipose tissue, liver fibrosis 18 27) Body weight, adipose tissue weights, FER, TG, glucose, cell number and size of (inguinal, epididymal) adipose tissue, liver fibrosis 19 28) Body weight, total cholesterol, TG, HDL, gene expression 20 29) Body weight, FER, liver weight, total cholesterol, LDL, HDL, glucose, ALT, creatinine, viceral adipose, liver tissue, epididymal adipose tissue 21 30) Total cholesterol, glucose, gene expression 22 31) Body weight, total cholesterol, gene expression 23 32) Body weight, food intake, FER, liver weight, abdomal fat weight, epididymal and peri...…”

“…C57bl/6j 6 M High fat diet 2 Ye et al (2016) 11) C57bl/6j 6 M High fat diet 3 Oh et al (2016) 12) C57bl/6j 7 M High fat diet 4 Lee et al (2016) 13) C57bl/6 6 M High fat diet 5 Jang et al (2016) 14) Icr 4 -High fat diet 6 Song et al (2016) 15) C57bl/6 5 M High fat diet 7 Ma et al (2015) 16) C57bl/6 -M High fat diet 8 Kim et al (2015) 17) C57bl/6 5 M High fat diet 9 Choi et al (2015) 18) Icr 5 F High fat diet 10 Yoo et al (2015) 19) C57bl/6n 7 M High fat diet 11 Kim et al (2015) 20) C57bl/6 4 -High fat diet 12 Youn et al (2015) 21) Icr 6 F High fat diet 13 Min et al (2015) 22) C57bl/6 4 -High fat diet 14 Keum et al (2015) 23) C57bl/6j 6 M High fat diet 15 Kee et al (2014) 24) SD -M High fat diet 16 Lee et al (2014) 25) SD -M High fat diet 17 Seok et al (2014) 26) C57bl/6n 7 M High fat diet 18 Kim et al (2014) 27) C57bl/6n 7 M High fat diet 19 Shin et al (2014) 28) SD -F Estrogen deficient 20 Kang et al (2014) 29) C57bl/6 10 M High fat diet 30) Icr 6 M High fat diet 22 Lee et al (2014) 31) C57bl/6j 8 M High fat diet 23 Yoon et al (2014) …”