The comparative inotropic effects of six clinically used antiarrhythmic agents

Hammermeister, K.E.; Boerth, Robert C.; Warbasse, J.Richard

doi:10.1016/0002-8703(72)90179-2

Cited by 74 publications

(10 citation statements)

References 23 publications

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“…In a study of isometrically contracting papillary muscle in the cat, procainamide caused less cardiodepression than quinidine, phenytoin, or lidocaine. 13 Similarly, in an invasive hemodynamic study in patients recovering from an acute myocardial infarction, lidocaine produced significant decreases in cardiac index and increases in left ventricular filling pressure that were not seen with procainamide.14 The findings of the present study are consistent with these earlier reports; procainamide produced less cardiodepression than either encainide or tocainide (a lidocaine analogue).…”

Section: Hemodynamic Effects Of Procainamidesupporting

confidence: 87%

Comparative hemodynamic effects of procainamide, tocainide, and encainide in severe chronic heart failure.

et al. 1990

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Section: Hemodynamic Effects Of Procainamidesupporting

confidence: 87%

Comparative hemodynamic effects of procainamide, tocainide, and encainide in severe chronic heart failure.

et al. 1990

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“…Others have shown that propranolol, phenytoin, ajmaline, quinidine, and lido caine [17][18][19] reduce the contractility of iso lated cardiac muscle, and indeed, data from the present study show that both lidocaine and quinidine reduced all measured indices of in vitro myocardial contractility. Pirlimy cin adenylate, however, up to a concentration of 1 mM had no effect on contractility in iso lated cat papillary muscles.…”

Section: Discussionsupporting

confidence: 82%

Antiarrhythmic and Cardiovascular Actions of the New Antibiotic Agent Pirlimycin Adenylate

et al. 1983

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Pirlimycin adenylate (U-63,440) is a clindamycin analog possessing antiarrhythmic activity. In the anesthetized dog, the sustained ventricular tachycardia produced by ouabain intoxication is converted to a normal sinus rhythm with an average dose of 26.0 ± 5.1 mg/kg of pirlimycin adenylate (range 13.4–40.7 mg/kg i.v.). The drug failed, however, to decrease arrhythmia frequency in a modified 2-day Harris dog preparation even with doses of up to 100 mg/kg. The efficacy of pirlimycin adenylate against ouabain-induced arrhythmias cannot be ascribed to a local anesthetic action, since concentrations of up to 5 × 10^–3M produced only a small (26 ± 5%) reduction in the spike amplitude of desheathed isolated frog sciatic nerves. In contrast, lidocaine (5 × 10^–3M) produced a 91 % reduction in single spike amplitude. Neither did pirlimycin adenylate (up to 10^–3M) produce any negative inotropic effect in isolated cat papillary muscles, while both lidocaine and quinidine were cardiodepressant at 10^–3M. It is concluded that pirlimycin adenylate may be an interesting prototype antiarrhythmic agent and further chemical modification of the drug molecule might increase the spectrum of antiarrhythmic activity without altering the drug’s toxicity.

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“…Sixteen healthy male volunteers (ages [18][19][20][21][22][23][24][25][26][27][28][29] years) participated in the study. Written, informed consent was obtained from each volunteer before participation in the study.…”

Section: Subjectsmentioning

confidence: 99%

The effect of concurrent oral administration of propranolol and disopyramide on cardiac function in healthy men.

Cathcart-Rake¹,

Coker²,

Atkins³

et al. 1980

Circulation

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Sixteen healthy men were evaluated for left ventricular performance changes and beta-blockade after therapeutic oral doses of disopyramide and propranolol administered alone and concurrently. The volunteers were randomly assigned to receive one of two drug treatment regimens that differed in the sequence and duration of administration of the drugs. Left ventricular function was assessed by echocardiographically determined ejection fraction (EF) and systolic time intervals. Beta-blockade was assessed by changes in exercise heart rate. Both disopyramide and propranolol exhibited negative inotropic activity, as evidenced by significant, although clinically inconsequential, decreases in EF and increases in the ratio of preejection period to left ventricular ejection time. The negative inotropic effects of a single 200-mg dose of disopyramide and an 80-mg dose of propranolol were comparable, while chronic disopyramide therapy (200 mg every 6 hours for 1 week) had a greater negative inotropic effect than chronic propranolol therapy (80 mg every 8 hours for 1 week). Only propranolol had beta-adrenoceptor blocking activity. When the drugs were administered concurrently, the negative inotropic effects of oral propranolol and disopyramide were neither additive nor synergistic.

show abstract

The comparative inotropic effects of six clinically used antiarrhythmic agents

Cited by 74 publications

References 23 publications

Comparative hemodynamic effects of procainamide, tocainide, and encainide in severe chronic heart failure.

Comparative hemodynamic effects of procainamide, tocainide, and encainide in severe chronic heart failure.

Antiarrhythmic and Cardiovascular Actions of the New Antibiotic Agent Pirlimycin Adenylate

The effect of concurrent oral administration of propranolol and disopyramide on cardiac function in healthy men.

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