The comparative anatomy of frontal eye fields in primates

Petit, Laurent; Pouget, Pierre

doi:10.1016/j.cortex.2019.02.023

Cited by 19 publications

(27 citation statements)

References 119 publications

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“…The functional organisation of the dorsal prefrontal and parietal cortices reveal similar network participation between humans and monkeys (Goulas et al., 2018, Margulies et al., 2009, Mars et al., 2011, Sallet et al., 2013, Vincent et al., 2007). These results indicate that the functions supported by the dorsal frontoparietal network—mostly visuospatial functions involving saccades, spatial working memory, and motor sequences (Parlatini et al., 2017, Petit and Pouget, 2019)—have been preserved along the evolutionary tree.…”

Section: Part Ii: Where Are We With Comparative Mri?mentioning

confidence: 77%

Large-scale comparative neuroimaging: Where are we and what do we need?

Schotten

Croxson

Mars

2019

Cortex

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Neuroimaging has a lot to offer comparative neuroscience. Although invasive “gold standard” techniques have a better spatial resolution, neuroimaging allows fast, whole-brain, repeatable, and multi-modal measurements of structure and function in living animals and post-mortem tissue. In the past years, comparative neuroimaging has increased in popularity. However, we argue that its most significant potential lies in its ability to collect large-scale datasets of many species to investigate principles of variability in brain organisation across whole orders of species—an ambition that is presently unfulfilled but achievable. We briefly review the current state of the field and explore what the current obstacles to such an approach are. We propose some calls to action.

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Section: Part Ii: Where Are We With Comparative Mri?mentioning

confidence: 77%

Large-scale comparative neuroimaging: Where are we and what do we need?

Schotten

Croxson

Mars

2019

Cortex

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“…First, the lack of similar sulcal organization in macaques and the relative expansion in the size of the human PFC (Donahue et al, 2018) complicate any solution that relies on the purely geometrical inter‐species registration of these areas. Second, even though cytoarchitecture may serve as a guiding principle in identifying homologies, in the PFC, it is usually at best a coarse approximation, for example, as illustrated by the fact that FEF lies in different BAs in the macaque and the human (viz., BA8 and BA6, and BA6, respectively; Paus, 1996; Petit & Pouget, 2019; Tehovnik et al, 2000). This implies that the cytoarchitecture of the PFC in the macaque isn't necessarily a good predictor of the location where fMRI activity is usually measured using conventional FEF localizer tasks in humans (for instance, see fig.…”

Section: General Discussion and Future Directionsmentioning

confidence: 99%

Structure, function and connectivity fingerprints of the frontal eye field versus the inferior frontal junction: A comprehensive comparison

Bedini

Baldauf

2021

Eur J of Neuroscience

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The human prefrontal cortex contains two prominent areas, the frontal eye field and the inferior frontal junction, that are crucially involved in the orchestrating functions of attention, working memory and cognitive control. Motivated by comparative evidence in non‐human primates, we review the human neuroimaging literature, suggesting that the functions of these regions can be clearly dissociated. We found remarkable differences in how these regions relate to sensory domains and visual topography, top‐down and bottom‐up spatial attention, spatial versus non‐spatial (i.e., feature‐ and object‐based) attention and working memory and, finally, the multiple‐demand system. Functional magnetic resonance imaging (fMRI) studies using multivariate pattern analysis reveal the selectivity of the frontal eye field and inferior frontal junction to spatial and non‐spatial information, respectively. The analysis of functional and effective connectivity provides evidence of the modulation of the activity in downstream visual areas from the frontal eye field and inferior frontal junction and sheds light on their reciprocal influences. We therefore suggest that future studies should aim at disentangling more explicitly the role of these regions in the control of spatial and non‐spatial selection. We propose that the analysis of the structural and functional connectivity (i.e., the connectivity fingerprints) of the frontal eye field and inferior frontal junction may be used to further characterize their involvement in a spatial (‘where’) and a non‐spatial (‘what’) network, respectively, highlighting segregated brain networks that allow biasing visual selection and working memory performance to support goal‐driven behaviour.

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“…In addition, while the present work addressed issues regarding the reproducibility of findings by replicating analyses in independent samples, our understanding of their functional significance is based on a meta-analysis and so the precise functional meaning of the observed differences remains largely a matter of conjecture ( Braga and Buckner, 2017 ; Laumann et al, 2015 ). In order to fully appreciate the significance of these cross-species differences in brain organization for human cognition, it will be necessary to understand how these patterns change across contexts, and, if possible, during active tasks states ( Petit and Pouget, 2019 ; Sharma et al, 2019 ). Understanding how functional patterns change across a common embedded space during periods of task engagement, could provide invaluable insight into how evolution has shaped many important aspects of human cognition ( Murphy et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Cross-species functional alignment reveals evolutionary hierarchy within the connectome

et al. 2020

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Evolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes in brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across species. It limits our ability to fully appreciate how evolution has shaped our brain, especially in systems associated with unique human cognitive capabilities that lack anatomical homologues in other species. Here, we develop a function-based method for cross-species alignment that enables the quantification of homologous regions between humans and rhesus macaques, even when their location is decoupled from anatomical landmarks. Critically, we find cross-species similarity in functional organization reflects a gradient of evolutionary change that decreases from unimodal systems and culminates with the most pronounced changes in posterior regions of the default mode network (angular gyrus, posterior cingulate and middle temporal cortices). Our findings suggest that the establishment of the default mode network, as the apex of a cognitive hierarchy, has changed in a complex manner during human evolution – even within subnetworks.

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The comparative anatomy of frontal eye fields in primates

Cited by 19 publications

References 119 publications

Large-scale comparative neuroimaging: Where are we and what do we need?

Large-scale comparative neuroimaging: Where are we and what do we need?

Structure, function and connectivity fingerprints of the frontal eye field versus the inferior frontal junction: A comprehensive comparison

Cross-species functional alignment reveals evolutionary hierarchy within the connectome

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