The comparative analysis of the treatment efficacy in patients with primary and secondary cancer of a liver with the use of RFA and MWA

Abstract

Background: KRAS mutations influence survival after hepatectomy for colorectal liver metastases (CRLM). However, their prognostic significance has never been evaluated in patients who undergo Associating Liver Partition and Portal vein occlusion for Staged hepatectomy (ALPPS). Methods: Between June 2011 and March 2016, twenty-six patients underwent ALPPS for CRLM. Complications were classified according to the Dindo-Clavien classification. Biand multivariate cox analyses were performed to evaluate variables potentially associated with survival. Results: Overall, morbidity grade !3a and 90-day mortality were 38.5% and 0%, respectively. Median follow-up from the time of discharge was 21.5 months (IQR 9.6-35.6). One and 3-years overall survival (OS) was 83.4 and 48.9 %, respectively. Patients with mutated KRAS had a median OS of 15.3 months versus 38.3 months for those with wild-type KRAS (p<0.0001). Median disease-free survival was 7.9 months, 5.6 versus 12.3 months for mutated and wild-type KRAS, respectively (p=0.023). KRAS mutation was found to be an independent risk factor for OS (HR 7.15, 95% CI 1.50-34.11;p=0.014). Conclusion: KRAS mutation is an independent predictor of poor survival after ALPPS. This finding will help to optimize patient selection, both avoiding futile surgical indication and maximizing the benefit for patients with extensive disease who are subjected to high-risk aggressive surgery.

lncRNA RBM5‐AS1 promotes cell proliferation and invasion by epigenetically silencing miR‐132/212 in hepatocellular carcinoma cells

“…Hepatocellular carcinoma (HCC) is a common malignant tumor in china with high incidence and metastasis rate, which is divided into primary and secondary types clinically (Trandofilov et al, 2019). In previous research, the pathogenesis of HCC is very complex, which is related to multiple factors, such as gene mutation, infection, immune injury (Daniel et al, 2018).…”