The comorbidity of bipolar disorder and axis II personality disorders: prevalence and clinical correlates

George, Elizabeth; Miklowitz, David J.; Richards, Jeffrey A.; Simoneau, Teresa L.; Taylor, Dawn O.

doi:10.1034/j.1399-5618.2003.00028.x

Cited by 123 publications

(97 citation statements)

References 49 publications

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“…Such an association is noteworthy, since comorbid personality and anxiety disorders exacerbate bipolar disorder even without the negative effects of substance abuse (Young et al, 1993;Carpenter et al, 1995;Ucock et al, 1998;Dunayevich et al, 2000;Feske et al, 2000;George et al, 2003). Given the implications for the management of patients with bipolar disorder and concurrent substance, anxiety, and/ or personality disorder, care should be taken to identify comorbid psychiatric illness in any patient population.…”

Section: Discussionmentioning

confidence: 99%

Comorbid disorders in patients with bipolar disorder and concomitant substance dependence

Mitchell

Brown

Rush

2007

Journal of Affective Disorders

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Objective-Substance dependence is common in bipolar disorder and is associated with an increase in Axis I and II comorbidity. Little research has compareed the relative rates of comorbidity among bipolar patients with dependence on different substances. Methods-TheMini International Neuropsychiatric Interview (M.I.N.I.) was used to assess 166 outpatients involved in one of three clinical trials of medicatiosn for bipolar disorder and substance dependence. Patients had concurrent alcohol dependence, cocaine dependence, or both conditions.Results-Generalized anxiety disorder and current depressed mood were significantly more common in bipolar patients with alcohol dependence than bipolar patients with cocaine dependence. Those with cocaine dependence had significantly higher rates of post-traumatic stress disorder and anti-social personality disorder and were more likely to present in a mixed mood state than patients dependent on alcohol. Cocaine dependent patients were more likely than alcohol dependent patients to have bipolar I relative to bipolar II.Limitations-This is a retrospective, cross-sectional data analysis using the M.I.N.I. for diagnosis.Conclusions-Cocaine dependence and alcohol dependence were associated with different clinical features and comorbid disorders in bipolar patients. The results may help confirm the validity of integrative models of mood, behavioral, anxiety, and personality disorders. Further studies on the causal relationship between substance dependence and concurrent and lifetime Axis I disorders for patients with bipolar disorders are indicated.

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Section: Discussionmentioning

confidence: 99%

Comorbid disorders in patients with bipolar disorder and concomitant substance dependence

Mitchell

Brown

Rush

2007

Journal of Affective Disorders

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“…[53] Birinci eksende herhangi bir eştanı için bu oranlar % 12 ile %46 arasındadır. [5,7,8,19,54] İlk sırada anksiyete bozuklukları, ikinci sırada alkol ve madde kullanım bozuklukları (MKB) yer almaktadır.…”

Section: Eştanıunclassified

Bipolar disorder in Turkey: A review

Gültekin¹,

Kesebir²,

Tamam³

2014

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖzetTürkiye'de bipolar bozukluk ile ilgili yapılmış çalışmaların incelenmesinde epidemiyolojik anlamda nitelikli alan çalışmasına rastlanmamıştır. Çalışmaların çoğu, hastane başvurusu kaynaklı ve klinik çalışmalardır, sistematik bir tarama içermemekte, epidemiyolojik veri toplama ya da sağlık hizmetlerine bilgi aktarma amaçlı değildir. Bu çalışmaların bulgularının toplumumuza genellenebilirliği geçerli ve güvenilir olmaktan uzaktır. Bununla birlikte, ülkemizin değişik bölgelerinde yapılmış çalışmaların bulgularının gözden geçirilerek oluşturulacak bir profilin hastalığın bize özgü özellikle-rinin tanınmasına ve risk etkenlerinin saptanmasına katkısı olacaktır. Tüm bu bilgiler bipolar bozukluk ile ilgili olarak, toplum ruh sağlığı hizmetlerinin oluşturulup geliştirilmesine temel oluştu-rabilir. Ülkemizde epidemiyolojik anlamlılığı olan, çok merkezli, toplum örneklemli ve geniş katılım-lı çalışmalara gereksinimi vardır. Psikiyatrik epidemiyoloji ve klinik araştırmalarımız gerekli bilimsel bazı bulundurmakla birlikte, hızlı kentleşme ve göç gibi toplumsal, özgün ve gelişimsel ilişkileri değerlendirebilecek güçte değildir. Bu gözden geçirmede, Türkiye'de bipolar bozukluk ile ilgili yapılmış çalışmalarda, öne çıkan epidemiyolojik bulguların, eksikliklerin ve gelecekte konuyla ilgili neler yapılabileceğinin araştırılarak tartışılması amaçlanmıştır.Anahtar sözcükler: Bipolar bozukluk, epidemiyoloji, Türkiye. AbstractAssessment of studies related with bipolar disorder in Turkey did not reveal an epidemiologically qualified field study. Most of the studies are hospital based or clinical studies which did not include a systematical scanning and did not aim to collect any epidemiological data and transfer information to health authorities. The generalizability of these studies to our community is far from being valid and reliable. On the other hand, a profile which will be created by reviewing the findings of these studies performed in various regions of Turkey will have a contribution to knowing the "unique to us" features of bipolar disorder and determining cultural risk factors. All this information can constitute a basis for formation and development of public mental health services related with bipolar disorder. In Turkey, the need for epidemiologically significant, polycentric, public sampled studies with broad participation is indispensable. Although our psychiatric epidemiology and clinical studies include necessary scientific basis, they are not powerful enough to evaluate the authentic and progressional relations such as rapid urbanization and immigration. The aim of this review is to evaluate and discuss prominent epidemiological findings, deficiencies and possibile future activities related with studies conducted in Turkey about bipolar disorder..

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“…In our study the same relationship exists in the context of the comorbidities. Both co-morbid anxiety (Otto et al 2006) and personality disorders (George et al 2003) have been found to modify the course of bipolar disorder, which reflects in worse marital functioning as well and should be taken into consideration. What is interesting, both of these factors turned out to be insignificant in the context of dyadic cohesion.…”

Section: Discussionmentioning

confidence: 99%