The commercial harvest of devil's claw (Harpagophytum spp.) in southern Africa: The devil's in the details

Stewart, Kristine M.; Cole, David M.

doi:10.1016/j.jep.2005.07.004

Cited by 107 publications

(94 citation statements)

References 26 publications

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“…참깨과에 속하는 천수근(Harpagophytum procumbens) 은 Devil's claw, Grapple plant라고 불리며 Namibia, Botswana 및 남아프리카 북부지방에 널리 분포되어 있다 1) . 현지에서는 외상, 월경장애, 출산통, 소화장애, 관절염 등 에 사용하였으며 2) , 1960년대 천수근의 Secondary roots 으로부터 얻어진 추출물이 효능이 있다는 것이 알려짐을 시작으로 1) 최근 임상적 효과로 관절염 3) , 류머티즘 4) , 혈액 Table I이고, 질량 검출기의 조건은 Table II 와 같다.…”

Section: 서론»»»unclassified

“…현지에서는 외상, 월경장애, 출산통, 소화장애, 관절염 등 에 사용하였으며 2) , 1960년대 천수근의 Secondary roots 으로부터 얻어진 추출물이 효능이 있다는 것이 알려짐을 시작으로 1) 최근 임상적 효과로 관절염 3) , 류머티즘 4) , 혈액 Table I이고, 질량 검출기의 조건은 Table II 와 같다. Table I, Table II의 (Fig.…”

Section: 서론»»»unclassified

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Identification of Novel Standard Compounds for Standardization of Sinbaro3 Pharmacopuncture

Lee¹,

Lee²,

Kim³

et al. 2015

Journal of Korean Medicine Rehabilitation

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Objectives To investigate and validate potential standard compounds for standardization of Sinbaro3 pharmacopuncture prepared at OO Hospital of Korean Medicine. Methods Sinbaro3 pharmacopuncture was prepared by extraction, purification and hydrolysis of Harpagophytum procumbens, and various potential standard compounds were quantified through HPLC-UV and HPLC-MS analysis. Validation was examined by assessing specificity, linearity, precision, and accuracy. Results The retention time of harpagide and cinnamic acid were 15.2 min and 28.2 min, respectively, and both showed good linearity in analysis by concentration at 0.9999 and 0.9998, respectively. Intra-day variation of precision was 0.0015~0.0045% and 0.0058~ 0.1629%, while inter-day variation of precision was 0.0011~0.0243% and 0.0098~0.1629%, and that of accuracy was 99.53~99.89% and 99.50~99.91%, respectively. Conclusions Harpagide and cinnamic acid, which are hydrolyzates of harpagoside within Sinbaro3 pharmacopuncture, were both validated using HPLC-MS and HPLC-UV analysis, and Sinbaro3 pharmacopuncture contained 78.41 ug/ml harpagide, and 2.05 ug/ml cinnamic acid. .

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Section: 서론»»»unclassified

Identification of Novel Standard Compounds for Standardization of Sinbaro3 Pharmacopuncture

Lee¹,

Lee²,

Kim³

et al. 2015

Journal of Korean Medicine Rehabilitation

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“…Devil's Claw (DC) gets its name from the sharply curved tiny hooks that cover its fruit. Other popular names include: grapple plant, wood spider, duiwelsklou, Afrikanische, Teufelskralle, griffe du diable and sengaparile [1,2]. The DC contains various compounds such as harpagoside (a major active component), harpagide, verbascoside, carbohydrates, aromatic acids, phytosterols and flavonoids [3].…”

Section: Introductionmentioning

confidence: 99%

“…Also, this herb is contraindicated in patients suffering from peptic ulcers or gall stones. Care should also be considered for human beings with cardiovascular disorders [1]. Furthermore, herbal medicine products are not free of side effects for pregnant women and fetal abnormality may be developed [10].…”

Section: Introductionmentioning

confidence: 99%

Teratogenic Effects of Harpagophytum procumbens Ethanolic Extract in Mice and Fetuses

Davari

Miri

Shahraki

2016

Zahedan J Res Med Sci

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Background: Harpagophytum procumbens is a traditional herbal plant belonging to the Pedaliaceae family. This herb is used to treat a wide range of disorders including rheumatism, arthritis, inflammations, gastrointestinal disturbances, hepatic diseases, and anemia. Side effects of this medicinal plant are unknown during pregnancy period. Objectives: Therefore, the objective of the present research was to evaluate the teratogenic effects and congenital malformation resulting from using Harpagophytum procumbens ethanolic extract in pregnant Balb/C mice. Methods: In this experimental study, female mice (N = 40) which had successful mating were kept in standard conditions. Then the ethanolic extract of the plant (200, 400, 600 mg/kg) was given to the treatment groups by gastric gavage route on 0 -14 th days of ges-

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“…자생한방병원에서는 이러한 천수근 추출물을 이용하여 신바로3 약침을 조제하였으며 신바로3 약침은 Harpagoside를 가수분해하여 Harpagide와 Cinnamic acid 의 함량을 높혀 사용하고 있다 9) . H. procumbens의 추출물은 퇴행성 류마티스 관절염, 골관절염, 건염, 신장염, 심장질환, 소화불량 및 식욕감퇴 치료 10,11) , 혈액순환장애 12) 와 신경통 13) 등에도 효과가 있는…”

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Single-dose Intramuscular Toxicity Studies of Shinbaro3 Pharmacopunture in Sprague-Dawley Rats and Beagle Dogs

Lee¹,

Lee²,

Lee³

et al. 2015

Journal of Korean Medicine Rehabilitation

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Objectives To assess the safety of Shinbaro3 Pharmacopuncture by analyzing the potential single-dose intramuscular toxicity of Shinbaro3 Pharmacopuncture at various dose levels in SD (Spraque-Dawley) rats and Beagle dogs. Methods For evaluation of single-dose intramuscular toxicity of Shinbaro3 Pharmacopuncture, 40 SD rats (20 male and 20 famale) and 4 Beagle dogs (2 male and 2 female) were used. The rats were divided in four groups of 10 each, and treated intramuscularly with Shinbaro3 Pharmacopuncture at doses of 0.3, 0.6 and 1.2 mg/kg in distilled water, and distilled water as a vehicle control group, respectively. The Beagle dogs were divided into two groups of 2 each, and treated intramuscularly with Shinbaro3 Pharmacopuncture at doses of 0.15, and 0.3 mg/kg in distilled water, respectively, and signs of toxicity were observed. After a wash-out period of 3 days, the procedure was repeated with Shinbaro3 Pharmacopuncture at doses of 0.6, and 1.2 mg/kg in distilled water, respectively. Mortality, body weight changes, and necropsy findings were examined during the study period. Results There were no mortalities in either the SD rats or Beagle dogs. There were also no significant differences in adverse effects, body weight, or necropsy findings between the Shinbaro3 Pharmacopuncture and control groups. Conclusions There results suggest that the lethal dose 50 (LD50) and approximate lethal dose (ALD) value of the test substance Shinbaro3 Pharmacopuncture are higher than 1.2 mg/kg in SD rats and Beagle dogs. , 그

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The commercial harvest of devil's claw (Harpagophytum spp.) in southern Africa: The devil's in the details

Cited by 107 publications

References 26 publications

Identification of Novel Standard Compounds for Standardization of Sinbaro3 Pharmacopuncture

Identification of Novel Standard Compounds for Standardization of Sinbaro3 Pharmacopuncture

Teratogenic Effects of Harpagophytum procumbens Ethanolic Extract in Mice and Fetuses

Single-dose Intramuscular Toxicity Studies of Shinbaro3 Pharmacopunture in Sprague-Dawley Rats and Beagle Dogs

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