The combined use of in-bed monitoring and an adsorption model to anticipate breakthrough during expanded bed adsorption

Mathematical modelling of expanded bed adsorption – a perspective on in silico process design

“…The height of a single plate can then be calculated as HETP = L / N , where L is the column length. Several authors have extended this model to EBA columns. The bed expansion and voidage was approximated by assuming a constant particle size, and applying the Richardson‐Zaki Equation to account for the hindered settling velocity.…”

“…Pällson and co‐workers and Theodossiou et al report that a combination of the Richardson‐Zaki and HETP models provides misleading information about the plate number and the axial dispersion in the column. To allow comparison of different resins and columns, Pällson and co‐workers proposed to base the plate number and vessel dispersion number on the settled bed height, but did not include a particle size distribution . In addition, Hubbuch et al pointed out that the system's piping, the flow distributor and column outlet design all contribute to the vessel dispersion number and the HETP.…”

Prediction of ion-exchange column breakthrough curves by constant-pattern wave approach

“…Although a variety of models were available to predict the fixed-bed dynamics [15][16][17][18][19][20][21], the non-linear wave propagation theory provided a simple method to estimate the column breakthrough times for any types of adsorption isotherms [22][23][24]. Because the needed assumptions, infinite mass-transfer rate and local equilibrium, of the non-linear wave propagation theory are not always met for fixed-bed operations, a constantpattern wave approach was proposed to predict the breakthrough curves of fixed-bed adsorption processes with Langmuir or Freundlich adsorption isotherms [25].…”

Application of surface molecular imprinting adsorbent in expanded bed for the adsorption of Ni2+ and adsorption model

“…Incorporating fine crystalline quartz or metal particles into the matrix of cross-linked agarose is one example [trade name STREAMLINE (Amersham Biosciences, Uppsala, Sweden)]. The matrix has been widely applied in expanded-bed adsorption (Bruce and Chase, 2002;Badriyhal et al, 2003;Huiyi et al, 2003;Fernandez-Lahore et al, 2000).…”