The combined use of edaravone, diuretics, and nonsteroidal anti-inflammatory drugs caused acute kidney injury in an elderly patient with chronic kidney disease

Abstract

The purpose of this study was to draw attention

Drug Class Combination–Associated Acute Kidney Injury

“…Overall, reports of 56 combinations (73.7%) were considered VL quality ; 12 combinations (15.8%) were considered L quality. 10,11,[75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94] There were 8 (10.5%) combinations of M quality, 26,33,80,[95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113][114] and no study was ranked as being of high quality. Of the combinations, 58 (76%) had a single article for review.…”

“…10 citations met inclusion criteria for review of the NSAIDs and diuretics drug class combination, consisting of 12 drug-drug combinations evaluated. 26,33,80,[95][96][97][98][99][100][101] The proposed mechanism of nephrotoxicity for this combination is a pharmacodynamic effect on the kidney with a decrease in prostaglandin synthesis by NSAIDs causing afferent vasoconstriction and a decrease in effective blood volume caused by diuretics. 97,100 Furosemide was the most commonly assessed diuretic, and indomethacin was the most common NSAID.…”

“…97,100 Furosemide was the most commonly assessed diuretic, and indomethacin was the most common NSAID. 26,33,80,97,99,100 The majority were either case reports or case series, although there was a single randomized study. Lee et al 97 randomized 63 premature infants receiving indomethacin to either placebo or furosemide to evaluate their effects on patent ductus arteriosus and renal function.…”

γ‐Glutamylcysteine Alleviates Ischemic Stroke‐Induced Neuronal Apoptosis by Inhibiting ROS‐Mediated Endoplasmic Reticulum Stress

“…Edaravone is a currently listed drug used to treat ischemic stroke in the clinic partly by capturing and reducing excessive ROS [10,11]. However, renal disorders that occur during or after treatment with edaravone have drawn attention [12,13]. In addition to medications, some endogenous substances can also scavenge ROS.…”