The combined signatures of telomere and immune cell landscape provide a prognostic and therapeutic biomarker in glioma
Xu Han,
Zihan Yan,
Kaiyu Fan
et al.
Abstract:BackgroundGliomas, the most prevalent primary malignant tumors of the central nervous system in adults, exhibit slow growth in lower-grade gliomas (LGG). However, the majority of LGG cases progress to high-grade gliomas, posing challenges for prognostication. The tumor microenvironment (TME), characterized by telomere-related genes and immune cell infiltration, strongly influences glioma growth and therapeutic response. Therefore, our objective was to develop a Telomere-TME (TM-TME) classifier that integrates … Show more
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