The combined method to synthesis silica nanoparticle by Stöber process

Ren, Gaoyuan; Su, Hongjiu; Wang, Shudong

doi:10.1007/s10971-020-05322-y

Cited by 32 publications

(12 citation statements)

References 49 publications

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“…Transmission electron microscopy (TEM) images (Figure S3) showed the formation of supramolecular aggregates in P, whereas Scr was impervious to intramolecular condensation. We then prepared carboxyl-labeled SiO 2 NPs using the modified Stöber method . The X-ray diffraction (XRD) patterns of the synthesized SiO 2 NPs (Figure S4a) show they are amorphous, consistent with previous reports .…”

Section: Legumain-mediated Aggregation Of P-sio2 Nps In Vitromentioning

confidence: 99%

Targeted Enzyme Activity Imaging with Quantitative Phase Microscopy

Tanwar,

Wu,

Zahn

et al. 2023

Nano Lett.

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Quantitative phase imaging (QPI) is a powerful optical imaging modality for label-free, rapid, and three-dimensional (3D) monitoring of cells and tissues. However, molecular imaging of important intracellular biomolecules such as enzymes remains a largely unexplored area for QPI. Herein, we introduce a fundamentally new approach by designing QPI contrast agents that allow sensitive detection of intracellular biomolecules. We report a new class of bio-orthogonal QPI-nanoprobes for in situ high-contrast refractive index (RI) imaging of enzyme activity. The nanoprobes feature silica nanoparticles (SiO2 NPs) having higher RI than endogenous cellular components and surface-anchored cyanobenzothiazole-cysteine (CBT-Cys) conjugated enzyme-responsive peptide sequences. The nanoprobes specifically aggregated in cells with target enzyme activity, increasing intracellular RI and enabling precise visualization of intracellular enzyme activity. We envision that this general design of QPI-nanoprobes could open doors for spatial–temporal mapping of enzyme activity with direct implications for disease diagnosis and evaluating the therapeutic efficacy.

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Section: Legumain-mediated Aggregation Of P-sio2 Nps In Vitromentioning

confidence: 99%

Targeted Enzyme Activity Imaging with Quantitative Phase Microscopy

Tanwar,

Wu,

Zahn

et al. 2023

Nano Lett.

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“…In this method, different types of silicates such as tetraethoxysilane are mixed with ammonia, water, and ethanol to synthesize the requested silica nanoparticles. The concentration of solvents and silica additives can determine the size of the nanoparticles [166]. In the reverse microemulsion method, the spherical micelles are formed by adding a surfactant to an organic solvent that is transparent and thermodynamically stable.…”

Section: Synthesis Routes Of Silicamentioning

confidence: 99%

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

et al. 2022

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This review provides a summary of recent progress in the development of different nano-platforms for the efficient synergistic effect between photodynamic therapy and chemotherapy. In particular, this review focuses on various methods in which photosensitizers and chemotherapeutic agents are co-delivered to the targeted tumor site. In many cases, the photosensitizers act as drug carriers, but this review, also covers different types of appropriate nanocarriers that aid in the delivery of photosensitizers to the tumor site. These nanocarriers include transition metal, silica and graphene-based materials, liposomes, dendrimers, polymers, metal–organic frameworks, nano emulsions, and biologically derived nanocarriers. Many studies have demonstrated various benefits from using these nanocarriers including enhanced water solubility, stability, longer circulation times, and higher accumulation of therapeutic agents/photosensitizers at tumor sites. This review also describes novel approaches from different research groups that utilize various targeting strategies to increase treatment efficacy through simultaneous photodynamic therapy and chemotherapy.

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“…The literature reports various examples of matrices such as silica [ 18 , 19 , 20 , 21 , 22 , 23 ], polymers [ 24 , 25 , 26 ], starch [ 27 ], zeolites [ 28 , 29 , 30 ], potassium aluminum sulfate [ 31 ], trisodium citrate [ 32 ], and sodium chloride crystals [ 33 ]. Currently, silica is a powerful and effective matrix thanks to its optical transparency [ 34 , 35 ], biocompatibility [ 34 ], low toxicity [ 34 , 36 ], tunable dielectric properties [ 37 ], and potential for size and surface customization [ 34 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Luminescent Composite Carbon/SiO2 Structures: Synthesis and Applications

et al. 2022

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Luminescent carbon nanostructures (CNSs) have attracted great interest from the scientific community due to their photoluminescent properties, structural features, low toxicity, and a great variety of possible applications. Unfortunately, a few problems hinder their further development. These include the difficulties of separating a mixture of nanostructures after synthesis and the dependence of their properties on the environment and the aggregate state. The application of a silica matrix to obtain luminescent composite particles minimizes these problems and improves optical properties, reduces photoluminescence quenching, and leads to wider applications. We describe two methods for the formation of silica composites containing CNSs: inclusion of CNSs into silica particles and their grafting onto the silica surface. Moreover, we present approaches to the synthesis of multifunctional particles. They combine the unique properties of silica and fluorescent CNSs, as well as magnetic, photosensitizing, and luminescent properties via the combination of functional nanoparticles such as iron oxide nanoparticles, titanium dioxide nanoparticles, quantum dots (QDs), and gold nanoclusters (AuNCs). Lastly, we discuss the advantages and challenges of these structures and their applications. The novelty of this review involves the detailed description of the approaches for the silica application as a matrix for the CNSs. This will support researchers in solving fundamental and applied problems of this type of carbon-based nanoobjects.

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The combined method to synthesis silica nanoparticle by Stöber process

Cited by 32 publications

References 49 publications

Targeted Enzyme Activity Imaging with Quantitative Phase Microscopy

Targeted Enzyme Activity Imaging with Quantitative Phase Microscopy

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

Luminescent Composite Carbon/SiO2 Structures: Synthesis and Applications

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