The combined maternal administration of magnesium sulfate and aminophylline reduces intraventricular hemorrhage in very preterm neonates

Renzo, Gian Carlo Di; Mignosa, Marcella; Gerli, Sandro; Burnelli, Liliana; Luzi, G.; Clerici, Graziano; Taddei, Fabiana; Marinelli, Doretta; Bragetti, P; Mezzetti, Daniele; Torre, Benedetta Della; Fantauzzi, A.; Lungarotti, M. S.

doi:10.1016/j.ajog.2004.07.078

Cited by 33 publications

(11 citation statements)

References 29 publications

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“…To date, the data indicating an association, at large doses, with pediatric neuronal injury and death, as has been shown in the Cochrane Database of Systematic Reviews, 5 and our own published research 1,20,34,35 far outweigh the data indicating pediatric health outcome benefit. 62 It is, on the other hand, conceivable that, in the setting of preterm labor, the combination of an evidence-based tocolytic with low doses of MgSO 4 (if, in fact, low dose, magnesium is found to be neuroprotective), as well as, perhaps, drugs such as aminophylline, 63 could simultaneously delay delivery in some women having preterm labor, while, at the same time, protecting the developing nervous system of their babies. The proper testing of this concept would require the conduct of well-designed, randomized clinical trials.…”

Section: In Closingmentioning

confidence: 99%

Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor

Mittendorf

Dammann

2005

J Perinatol

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High-dosage, tocolytic magnesium sulfate (MgSO 4 ) administered to pregnant women during preterm labor can be toxic, and sometimes lethal, for their newborns (Cochrane Database of Systematic Reviews (relative mortality risk 2.82, 95% confidence interval 1.2-6.6)). Based on the results of the Magnesium and Neurologic Endpoints Trial and the work of many others, a unifying triangular concept is proposed to account for the increased prevalence of brain lesions, with their likely resultant mortality, in neonates and infants exposed to high-dose MgSO 4 in the context of preterm labor. We review the evidence that: (1) elevated circulating levels of serum ionized magnesium occurring in mothers, and therefore in their babies, at the time of delivery are associated with subsequent neonatal intraventricular hemorrhage (IVH); (2) neonatal IVH is strongly associated with lenticulostriate vasculopathy (LSV), an unusual mineralizing lesion involving the thalami and basal ganglia of the neonate; and, (3) exposure to 50 g or more of tocolytic MgSO 4 during preterm labor is associated with the development of LSV.

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Section: In Closingmentioning

confidence: 99%

Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor

Mittendorf

Dammann

2005

J Perinatol

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“…Tocolytic MgSO 4 can be an additional resource for neonatal Mg because fetal Mg is dependent on maternal sources [30][31][32]. Di Renzo et al [33] found that combined antenatal administration of MgSO 4 and aminophylline led to a substantial reduction in the IVH rate. Garnier et al [34] suggested that the increase in CSF Mg during oxygen-glucose deprivation has a neuroprotective role.…”

Section: Discussionmentioning

confidence: 99%

Magnesium Sulfate Tocolysis and Intraventricular Hemorrhage in Very Preterm Infants

Petrová

Mehta

2011

Indian J Pediatr

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“…Rose et al in 2008 (28). In their study, magnesium sulfate had no phylline and magnesium sulfate would result in less IVH in neonates under 30 weeks but it had no effect on respiratory distress syndrome, patent ductus arteriosus, and retinopathy (24).…”

Section: Discussionmentioning

confidence: 99%

“…The study by Carlo Gian et al in 2005 revealed that the use of aminophylline and magnesium sulfate was accompanied by decreased Intraventricular hemorrhage in neonates under 30 weeks' gestational age (24). However, the study by Nakazawa and colleagues in 2015 showed that tocolytic therapy with magnesium sulfate would result in increased risk of death, neurological pathologies, and Intraventricular hemorrhage in neonates (25).…”

Section: Introductionmentioning

confidence: 94%

The Survey of Magnesium Sulfate in Prevention of Intraventricular Hemorrhage in Premature Infants: A Randomized Clinical Trial

et al. 2017

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Background: Intraventricular hemorrhage (IVH) is a common complication seen in premature infants. Since the brain intraventricular hemorrhage in any degree of risk is an important factor in long-term neuropathology, the role of magnesium sulfate on cerebral hemorrhage requires further investigation. Therefore, this study aimed to investigate the effect of magnesium sulfate on intraventricular hemorrhage in infants of mothers with premature rupture of membranes.

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The combined maternal administration of magnesium sulfate and aminophylline reduces intraventricular hemorrhage in very preterm neonates

Cited by 33 publications

References 29 publications

Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor

Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor

Magnesium Sulfate Tocolysis and Intraventricular Hemorrhage in Very Preterm Infants

The Survey of Magnesium Sulfate in Prevention of Intraventricular Hemorrhage in Premature Infants: A Randomized Clinical Trial

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