The combined effect of subthalamic nuclei deep brain stimulation and l-dopa increases emotion recognition in Parkinson’s disease

Mondillon, Laurie; Mermillod, Martial; Musca, Serban; Rieu, Isabelle; Vidal, Tiphaine; Chambres, Patrick; Auxiette, Catherine; H, Dalens; Coulangeon, L.-M.; Jalenques, Isabelle; Lemaire, Jean‐Jacques; Ulla, Miguel; Derost, Philippe; Marqués, Ana; Durif, Franck

doi:10.1016/j.neuropsychologia.2012.08.016

Cited by 22 publications

(50 citation statements)

References 108 publications

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“…Second, as the severe motor deficit in the off‐drug state (and/or off‐stimulation condition in the postoperative condition) prohibited reliable emotional assessments in patients with advanced PD, both the neuropsychological and the metabolic assessments were performed in the on‐drug state (and on‐stimulation). The use of dopaminergic medication (and stimulation) in the on versus off conditions would be an efficient way to explore a potential interaction between STN DBS and l ‐dopa at the level of emotional dysfunctions in PD (Mondillon et al ., ). Third, a general brain damage‐induced cognitive decline (Mandal, Tandon, & Asthana, ) between the pre‐ and postoperative situations can be excluded, given the absence of any significant difference in performances on the general neuropsychological tests, notably the composite scale (MDRS).…”

Section: Discussionmentioning

confidence: 97%

Pre‐frontal‐insular‐cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease

Ory

Jeune

Haegelen

et al. 2015

Journal of Neuropsychology

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Subthalamic nucleus (STN) deep brain stimulation (DBS) has recently advanced our understanding of the major role played by this basal ganglion in human emotion. Research indicates that STN DBS can induce modifications in all components of emotion, and neuroimaging studies have shown that the metabolic modifications correlated with these emotional disturbances following surgery are both task- and sensory input-dependent. Nevertheless, to date, these modifications have not been confirmed for all emotional components, notably subjective emotional experience, or feelings. To identify the neural network underlying the modification of feelings following STN DBS, we assessed 16 patients with Parkinson's disease before and after surgery, using both subjective assessments of emotional experience and [F]fluorodeoxyglucose positron emission tomography ( FDG-PET). The patients viewed six film excerpts intended to elicit happy, angry, fearful, sad, disgusted, and neutral feelings, and they self-rated the intensity of these feelings. After DBS, there was a significant reduction in the intensity of the disgust feeling. Correlations were observed between decreased disgust experience and cerebral glucose metabolism (FDG uptake) in the bilateral pre-frontal cortices (orbitofrontal, dorsolateral, and inferior frontal gyri), bilateral insula, and right cerebellum. We suggest that the STN contributes to the synchronization process underlying the emergence of feelings.

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Section: Discussionmentioning

confidence: 97%

Pre‐frontal‐insular‐cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease

Ory

Jeune

Haegelen

et al. 2015

Journal of Neuropsychology

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“…As a consequence, a motor disturbance, such as the speech and laryngeal control disturbances that have been reported following high-frequency STN DBS (see for example, Hammer, Barlow, Lyons, & Pahwa, 2010; see also, Hammer, Barlow, Lyons, & Pahwa, 2011), could contribute to a deficit in emotional prosody production and, in turn, to disturbed emotional prosody recognition. This hypothesis has already been proposed in the context of the recognition of facial expression following STN DBS in Parkinson’s disease patients (Mondillon et al, 2012). …”

Section: Discussionmentioning

confidence: 80%

Sensory contribution to vocal emotion deficit in Parkinson's disease after subthalamic stimulation

Péron

Cekic

Haegelen

et al. 2015

Cortex

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Subthalamic nucleus (STN) deep brain stimulation in Parkinson’s disease induces modifications in the recognition of emotion from voices (or emotional prosody). Nevertheless, the underlying mechanisms are still only poorly understood, and the role of acoustic features in these deficits has yet to be elucidated. Our aim was to identify the influence of acoustic features on changes in emotional prosody recognition following STN stimulation in Parkinson’s disease. To this end, we analysed the performances of patients on vocal emotion recognition in pre-versus post-operative groups, as well as of matched controls, entering the acoustic features of the stimuli into our statistical models. Analyses revealed that the post-operative biased ratings on the Fear scale when patients listened to happy stimuli were correlated with loudness, while the biased ratings on the Sadness scale when they listened to happiness were correlated with fundamental frequency (F0). Furthermore, disturbed ratings on the Happiness scale when the post-operative patients listened to sadness were found to be correlated with F0. These results suggest that inadequate use of acoustic features following subthalamic stimulation has a significant impact on emotional prosody recognition in patients with Parkinson’s disease, affecting the extraction and integration of acoustic cues during emotion perception.

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“…This possibility is consistent with the neural basis of embodiment theory (Niedenthal et al, 2010) which emphasizes the importance of the cortical integration of motor behavior in achieving a correct understanding of emotional stimuli. The idea that embodiment processes might contribute to these lower recognition rates is further supported by the analysis of the confusion matrices which shows that the decrease in categorization accuracy is not due to an increase in the recognition of neutral expressions, as might be the case with facial amimia in parkinsonian patients (Mondillon et al, 2012) but rather to a mismatch with other emotions, as the presence of tics in TS suggests. Unfortunately, the small sample of patients compared on the basis of the YGTSS did not allow us to confirm this relationship between the severity of tics and the severity of impairment of EFE recognition.…”

Section: Discussionmentioning

confidence: 86%

Rapid Presentation of Emotional Expressions Reveals New Emotional Impairments in Tourette’s Syndrome

Mermillod¹,

Devaux²,

Derost³

et al. 2013

Front. Hum. Neurosci.

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Objective: Based on a variety of empirical evidence obtained within the theoretical framework of embodiment theory, we considered it likely that motor disorders in Tourette’s syndrome (TS) would have emotional consequences for TS patients. However, previous research using emotional facial categorization tasks suggests that these consequences are limited to TS patients with obsessive-compulsive behaviors (OCB).Method: These studies used long stimulus presentations which allowed the participants to categorize the different emotional facial expressions (EFEs) on the basis of a perceptual analysis that might potentially hide a lack of emotional feeling for certain emotions. In order to reduce this perceptual bias, we used a rapid visual presentation procedure.Results: Using this new experimental method, we revealed different and surprising impairments on several EFEs in TS patients compared to matched healthy control participants. Moreover, a spatial frequency analysis of the visual signal processed by the patients suggests that these impairments may be located at a cortical level.Conclusion: The current study indicates that the rapid visual presentation paradigm makes it possible to identify various potential emotional disorders that were not revealed by the standard visual presentation procedures previously reported in the literature. Moreover, the spatial frequency analysis performed in our study suggests that emotional deficit in TS might lie at the level of temporal cortical areas dedicated to the processing of HSF visual information.

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The combined effect of subthalamic nuclei deep brain stimulation and l-dopa increases emotion recognition in Parkinson’s disease

Cited by 22 publications

References 108 publications

Pre‐frontal‐insular‐cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease

Pre‐frontal‐insular‐cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease

Sensory contribution to vocal emotion deficit in Parkinson's disease after subthalamic stimulation

Rapid Presentation of Emotional Expressions Reveals New Emotional Impairments in Tourette’s Syndrome

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