The Combined Effect of STAT3 and NF-Κb Inhibitors (The Last Links of the Cholinergic Anti-Inflammatory Pathway) on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis

Abstract

The review analyzed data on Immunomodulatory action of cholera toxin B subunit (CT-B) and the synthetic peptide LKEKK that corresponds to residues 16-20 in thymosin-α 1 and 131-135 in interferon-α 2 on the functional, NO-synthase and guanylate cyclase activity of T and B lymphocytes, of macrophage-like cell line RAW 264.7. According to the data presented, CT-B and the peptide bind to the cholera toxin receptor of the target cell with high affinity and trigger the following cascade of intracellular reactions: activation of inducible NO synthase → increase in NO production → increase in soluble guanylate cyclase activity → increase in the cyclic guanosine-3',5'-monophosphate level.