“…First, an identity measure, the sum of squared differences (SSD) of normalized intensities, as seen in (1) ref is the reference block from the previous frame, tar the target block in the current frame, and n the number of voxels in a block. A linear measure, the inverse Pearson correlation coefficient (PCC), is proposed in (2) and a statistical measure, based on maximum likelihood (MLE), introduced in (Cohen and Dinstein, 2002) and refined in (Boukerroui et al, 2003), is presented in (3) An overview of intensity similarity measures can be found in . For our data, SSD does not cope with relative intensity.…”