The combined effect of non-alcoholic fatty liver disease and metabolic syndrome on colorectal carcinoma mortality: a retrospective in Chinese females

Abstract

BackgroundThis research aimed to investigate whether metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD) had both individual and synergistic effects on the prognosis for female colorectal carcinoma (CRC) patients.MethodsThe relationship between CRC prognosis and NAFLD as well as MetS was evaluated in 764 female participants. Based on the NAFLD level, patients were divided into significant NAFLD (SNAFLD), “moderate” and “severe” level, and non-SNAFLD, “non” and “mild” level. All the patients were categorized into four subgroups according to the status of SNAFLD and MetS and then a comparison of CRC prognosis among those four groups was performed.ResultsNAFLD, SNAFLD, and MetS were independent factors for CRC-specific mortality with the adjustment of age and other confounders. The hazard ratio (HR) of CRC-specific mortality in MetS (+) SNAFLD (+) group was significantly higher than that in other three groups. Relative excess risk of interaction (RERI) was 2.203 with 95% CI ranged from 0.197 to 4.210, attributable proportion (AP) was 0.444 with range from 0.222 to 0.667, and synergy index (SI) of 2.256 with 95% CI from 1.252 to 4.065, indicating SNAFLD and MetS had a significant synergic effect on CRC-specific mortality.ConclusionsSNAFLD and MetS are independent risk factors for CRC-specific mortality in females. Moreover, those two diseases have a synergistic effect on promoting CRC-specific mortality.

Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

“…To investigate the association between NAFLD and the risk of colorectal cancer, pooled OR of colorectal cancer from ten studies was analyzed [21,[24][25][26][27][28][29][30][31][32]. A meta-analysis was conducted with the random-effect model (P < 0.01, I 2 = 83.5%).…”

The association between nonalcoholic fatty liver disease and esophageal, stomach, or colorectal cancer: National population-based cohort study

“…NAFLD (diagnosed by imaging study) independently increased the risk of overall colorectal neoplasm occurrence and severity at the time of the surveillance colonoscopy [16][17][18]. In a retrospective study in Chinese females, combined NAFLD and metabolic syndrome was an independent risk factor for colorectal cancer-specific mortality [19]. In addition, one meta-analysis suggested that NAFLD may increase the risk of cholangiocarcinoma, with a pooled odds ratio of 1.95 (95% confidence interval (CI): 1.36-2.79) [20].…”

Association between nonalcoholic fatty liver disease and extrahepatic cancers: A systematic review and meta-analysis

“…The results suggested that an obvious publication bias exists among these studies (P < 0.01) ( Figure 4A). Furthermore, the results of a subgroup analysis showed that the pooled OR of colorectal cancer in the cross-sectional studies [25,26,28,30,31] Figure 2A).…”