The combination of Pleurotus ferulae water extract and CpG-ODN enhances the immune responses and antitumor efficacy of HPV peptides pulsed dendritic cell-based vaccine

Li, Jinyu; Aipire, Adila; Luo, Jiaojiao; Yuan, Peng; Zhang, Fuchun

doi:10.1016/j.vaccine.2016.05.022

Cited by 24 publications

(31 citation statements)

References 45 publications

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“…We observed that the frequencies of iTregs in GUWE-HPV-DC-early group were significantly reduced compared to control group, which might contribute the induction of HPV-specific cellular responses. Similarly, our previous study found that the early therapeutic strategy reduced the frequencies of iTregs and induced strong HPV-specific cellular responses to inhibit the tumor growth29. We observed that the level of CD8 + T cell responses was negatively correlated with the frequencies of iTregs and the weight of tumor.…”

Section: Discussionsupporting

confidence: 81%

“…Many studies including ours have shown that herbal medicine extracts or its components can enhance antitumor immune responses through promoting the activation status of DCs28293233. In this study, we observed that GUWE improved the maturation and cytokine production of DCs, especially IL-12 production.…”

Section: Discussionsupporting

confidence: 54%

“…Our previous studies showed that PFWE could enhance the maturation and function of DCs, and the antitumor efficacy of HPV DC-based vaccine2829. Here, we prepared the HPV DC-based vaccine as the following: GUWE treated DCs were pulsed with HPV-16 E6/E7 peptides (GUWE-HPV-DCs).…”

Section: Resultsmentioning

confidence: 99%

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Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine

Aipire

Yuan

et al. 2017

Sci Rep

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Licorice has been used as herbal medicine and natural sweetener. Here, we prepared Glycyrrhiza uralensis water extract (GUWE) and investigated the effect of GUWE on the maturation and function of dendritic cells (DCs) and its adjuvant effect on DC-based vaccine. We observed that GUWE dose-dependently promoted DC maturation and cytokine secretion through TLR4 signaling pathway. The capacity of DC to stimulate allogenic splenocyte proliferation was also enhanced by GUWE treatment. Compared with control group, GUWE treated DCs pulsed with human papillomavirus (HPV)-16 E6/E7 peptides significantly inhibited the tumor growth in both early and late therapeutic groups. In early therapeutic group, the frequencies of induced regulatory T cells (iTregs: CD4+CD25−Fopx3+) and CD4+ and CD8+ T cells were significantly decreased and increased, respectively. HPV-16-specific CD8+ T cell responses were significantly induced and negatively correlated with iTreg frequencies and tumor weight. These results indicated the immunoregulatory activities of licorice.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 54%

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Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine

Aipire

Yuan

et al. 2017

Sci Rep

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“…For analysis of HPV-specific cellular responses, splenocytes (1×10 6 /ml) were treated with HPV-16 E6/E7 peptides and cultured overnight in the presence of Golgi stop (BD Biosciences). Cell surface and intracellular staining was performed according to our previous study [34]. All the fluorescence conjugated mAbs were purchased from BD Biosciences.…”

Section: Methodsmentioning

confidence: 99%

λ-Carrageenan improves the antitumor effect of dendritic cellbased vaccine

Aipire

Zhu

et al. 2017

Oncotarget

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In this study, we investigated the effect of λ-carrageenan on the maturation and function of dendritic cells (DCs) and its adjuvant effect on DC-based vaccine. We found that λ-carrageenan dose-dependently decreased the endocytosis of DCs, promoted DC maturation and increased cytokine production through TLR4 mediated signaling pathway. λ-carrageenan treatment also enhanced the ability of DCs in the stimulating allogenic splenocyte proliferation. In TC-1 tumor mouse model, HPV peptides pulsed λ-carrageenan-DC (HPV-CGN-DC) significantly inhibited tumor growth compared with control group. The frequencies of CD4+ and CD8+ T cells in spleens of tumor mice and their activation status were significantly increased in HPV-CGN-DC group, but the frequencies of natural regulatory T cells and CD11b+Gr-1+ cells were significantly decreased. Further, HPV-CGN-DC induced strong CD8+ T cell responses, which are negatively correlated with tumor volumes. The results suggested that λ-carrageenan promoted DC maturation through TLR4 signaling pathway and could be used as the adjuvant in DC-based vaccines.

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“…Un aspecto novedoso en la inmunidad antitumoral es la estimulación de células dendríticas (DC: dendritic cells) con un fenotipo más inmunogénico contra los tumores VPH positivos, estas DC pueden estimular de manera más eficiente la respuesta de los linfocitos T citotóxicos (LT CD8+) 29 . Esto se debe a que las DC potencian la respuesta inmune mediante diferentes señales como moléculas co-estimuladoras, presentación antigénica del complejo péptido-MHC y citocinas necesarias para que la activación de células T vírgenes (naïve) desarrollen respuestas celulares adaptativas más eficientes 30 .…”

Section: Avances En La Vacunación Terapéutica Contra Vph Como Adyuvanunclassified

Avances en el desarrollo de nuevas vacunas profilácticas y terapéuticas contra el Virus del Papiloma Humano

Rincón-Orozco

2016

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El uso de vacunas profilácticas contra el Virus del Papiloma Humano (VPH) de alto riesgo ha adquirido gran importancia debido al alto potencial oncogénico, de estos virus, especialmente por su asociación con el cáncer de cuello uterino, uno de los canceres más comunes y de mayor mortalidad en mujeres a nivel mundial. El objetivo de este artículo es describir las vacunas profilácticas y terapéuticas disponibles actualmente contra el VPH, analizando las características, ventajas, desventajas y estudios científicos sobre su uso y seguridad en la población. Se llevó a cabo una revisión de literatura de los últimos avances en el desarrollo de vacunas profilácticas y terapéuticas contra el VPH. La vacunación profiláctica es efectiva y esencial para la prevención del cáncer de cuello uterino causadas por VPH-16 y-18, pero no genera protección cruzada contra otros VPH de alto riesgo, esto ha encaminado a la creación de nuevas vacunas nanovalentes que protegen contra un número mas amplio de VPHs de alto riesgo. Por otra parte, las vacunas terapéuticas han demostrado en sus fases de estudio iniciales ser promisorias en la regresión de lesiones premalignas o malignas in situ.

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The combination of Pleurotus ferulae water extract and CpG-ODN enhances the immune responses and antitumor efficacy of HPV peptides pulsed dendritic cell-based vaccine

Cited by 24 publications

References 45 publications

Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine

Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine

λ-Carrageenan improves the antitumor effect of dendritic cellbased vaccine

Avances en el desarrollo de nuevas vacunas profilácticas y terapéuticas contra el Virus del Papiloma Humano

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