The combination of nanotechnology and traditional Chinese medicine (TCM) inspires the modernization of TCM: review on nanotechnology in TCM-based drug delivery systems

Zheng, Yinghao; Wang, Yun; Xia, Meng-Yu; Gao, Ya; Zhang, Lan; Song, Yanan; Zhang, Cun

doi:10.1007/s13346-021-01029-x

Cited by 24 publications

(13 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The material basis of TCM for disease prevention and treatment comes from biological active parts or active chemical components, but the intestinal absorption, metabolism and excretion of drugs by biological organism is an extremely complex process. TCM is expected to develop into nano drug delivery system through careful design of nanotechnology, which comprehensively improve the medicinal value of TCM for curing and preventing diseases ( Zheng et al., 2021 ). Nano traditional Chinese medicine (Nano TCM) refers to the effective components, original drugs and compound preparations of TCM made by nanotechnology with diameter less than 100 nm.…”

Section: Application Of Tcm Research Technology In Intestinal Barrier...mentioning

confidence: 99%

Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier

Che

Luo

Shi

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The effect of a drug on the intestinal flora and the intestinal barrier is an important evaluation index for drug safety and efficacy. Chemical synthetic drugs are widely used due to their advantages of fast efficacy and low doses, but they are prone to cause drug resistance and inhibit proton pumps, which may harm intestinal health. Traditional Chinese medicine (TCM) has been applied clinically for thousands of years, and how TCMs regulate intestinal health to achieve their effects of disease treatment has become a hot research topic that needs to be resolved. This paper reviews the recent research on the effects of TCMs on intestinal microorganisms and the intestinal mucosal barrier after entering the intestine, discusses the interaction mechanisms between TCMs and intestinal flora, and details the repair effect of TCMs on the intestinal mucosal barrier to provide a reference for the development, utilization, and modernization of TCM.

show abstract

Section: Application Of Tcm Research Technology In Intestinal Barrier...mentioning

confidence: 99%

Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier

Che

Luo

Shi

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Drug Delivery Improves Pharmacokinetics, Safety, and Bioavailability of Natural Products. The first fruits of the efforts of the combination of nanomedicine and TCM can be seen in the great success in the transport and delivery of natural bioactive compounds of therapeutic interest using a wide range of newly developed nanocarriers, including liposomes, niosomes, dendrimers, polymers, inorganic and organic nanoparticles, and metal−organic frameworks (see, e.g., Liu et al 40 or more recently in Pelaz et al 75 and Zheng et al 86 ) Thus, the many benefits derived from the use of nanocarriers may be applied to the products from TCM. First, nanocarriers enhance the stability and bioavailability of natural substances that are poorly soluble in water, thus improving the dosing efficiency.…”

Section: Mutual Benefits and Current Limitations Of The Integration O...mentioning

confidence: 99%

“…Currently, thanks to advances in biochemistry and in the isolation, purification, and characterization of active principles, plenty of TCM compounds known to have pharmacological properties have been studied and their mechanisms of action have been revealed. Plenty of examples can be found in many other reviews, especially in the protection, transport, and delivery of such compounds using nanocarriers and also in the improvement of the preparation technologies (see, e.g., recent ones in refs , , , , , and ). Herein, apart from drug delivery, several other studies which appeared in established journals that cover different areas of biomedicine and material science, such as combinatorial therapies, biosensing, acupuncture, manufacturing of TCM products and development of new nanomaterials, have been selected.…”

Section: Successful Cases Of Blending Tcm and Active Ingredients From...mentioning

confidence: 99%

“…Herein, the aim of this work is to analyze and discuss how the convergence between TCMand the use of natural products in TCMand nanomedicine, a recently developed technology compared with the millennia of different TCM experience, can contribute toward the harmonization between Western and Eastern approaches to health and disease. Other reviews and articles are mostly focused on the development of nanocarriers that can deliver natural products to targeted organs and tissues, and in the modernization of TCM preparation technologies with nanoengineering. − However, it is also worth focusing on other common challenges between nanomedicine and TCM. For instance, nanomedicine is a new medical technology that is trying to find its way into international pharmaceutical and medical markets.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities

et al. 2022

View full text Add to dashboard Cite

The integration of progressive technologies such as nanomedicine with the use of natural products from traditional medicine (TM) provides a unique opportunity for the longed-for harmonization between traditional and modern medicine. Although several actions have been initiated decades ago, a disparity of reasons including some misunderstandings between each other limits the possibilities of a truly complementation. Herein, we analyze some common challenges between nanomedicine and traditional Chinese medicine (TCM). These challenges, if solved in a consensual way, can give a boost to such harmonization. Nanomedicine is a recently born technology, while TCM has been used by the Chinese people for thousands of years. However, for these disciplines, the regulation and standardization of many of the protocols, especially related to the toxicity and safety, regulatory aspects, and manufacturing procedures, are under discussion. Besides, both TCM and nanomedicine still need to achieve a wider social acceptance. Herein, we first briefly discuss the strengths and weaknesses of TCM. This analysis serves to focus afterward on the aspects where TCM and nanomedicine can mutually help to bridge the existing gaps between TCM and Western modern medicine. As discussed, many of these challenges can be applied to TM in general. Finally, recent successful cases in scientific literature that merge TCM and nanomedicine are reviewed as examples of the benefits of this harmonization.

show abstract

“…As is known to all, advanced technology makes great contributions in TCM for cancer therapy, and thus promoting the rapid development of TCM, and the shortcomings of TCM in actual application are also maken up by interdisciplinary research ( Zheng et al, 2022 ). Therefore, in order to efficiently enhance the therapeutic value of TCM and accelerate the research progress of TCM in cancer therapy, application of advanced technology (e.g., nanotechnology, gene editing technology, RTCA technology, flow cytometry analysis technology, etc.)…”

Section: Introductionmentioning

confidence: 99%

Application of advanced technology in traditional Chinese medicine for cancer therapy

Zhang

Gao

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Although cancer has seriously threatened people’s health, it is also identified by the World Health Organization as a controllable, treatable and even curable chronic disease. Traditional Chinese medicine (TCM) has been extensively used to treat cancer due to its multiple targets, minimum side effects and potent therapeutic effects, and thus plays an important role in all stages of tumor therapy. With the continuous progress in cancer treatment, the overall efficacy of cancer therapy has been significantly improved, and the survival time of patients has been dramatically prolonged. In recent years, a series of advanced technologies, including nanotechnology, gene editing technology, real-time cell-based assay (RTCA) technology, and flow cytometry analysis technology, have been developed and applied to study TCM for cancer therapy, which efficiently improve the medicinal value of TCM and accelerate the research progress of TCM in cancer therapy. Therefore, the applications of these advanced technologies in TCM for cancer therapy are summarized in this review. We hope this review will provide a good guidance for TCM in cancer therapy.

show abstract

The combination of nanotechnology and traditional Chinese medicine (TCM) inspires the modernization of TCM: review on nanotechnology in TCM-based drug delivery systems

Cited by 24 publications

References 128 publications

Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier

Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier

The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities

Application of advanced technology in traditional Chinese medicine for cancer therapy

Contact Info

Product

Resources

About