The combination of intermittent caloric restriction and moderate-intensity interval training in decreasing blood glucose and CRP levels with a high glycemic index diet

Abstract

This study aims to analyze the effect of the combination of intermittent calorie restriction and moderate intensity interval training (MIIT) on serum c-reactive protein (CRP) levels as one of the inflammatory mediators and blood glucose levels in female mice exposed to a-high glycemic index diet. The sample of this study was female mice Balb/c strain, divided into four groups:, the control group (con), the intermittent calorie restriction group (restrict), the MIIT group (interv), and the combine group of intermittent calorie restriction and moderate-intensity interval training (restrict+interv). A high glycemic index diet was a high calorie and was provided by standard feed and oral gavage of 0.013 g/gBW glucosesolution. Intermittent calorie restriction was 50% reduction of the standard feed 3x/week. The MIIT was five-minute intervals of swimming and 30 seconds of passive rest consecutively for 30 minutes and 3x/week. Meanwhile, the treatment duration was four weeks. The oral glucose tolerance test consisting of fasting blood glucose (FBG) and a two-hour post -prandial (2HPP) blood glucose was measured before and after the treatment. CRP was examined only after the treatment. The restrict + interv group had a significant reduction in CRP levels compared to the restricted group (p = 0.005) and the interv group (p = 0.044). The FBG levels the restrict + interv group and restricted group had a significant decrease (p = 0.026). Moreover, 2HPP of the restrict + interv group and restricted group had a significant decline (p = 0.000). This study concludes that the combination of intermittent calorie restriction and moderate -intensity interval training can attenuate elevated serum CRP and blood glucose levels.

Response of TNF-α Levels and Blood Glucose Levels after Acute High-Intensity Intermittent Exercise in Overweight Women

“…The consequence of less energy being burned from the body makes the remaining energy excess be stored as fats which lead to overweight, and then obesity. Overweight cases increased 20% in men and 23% in women in 1975 (As'ad, 2022). A high-fat accumulation in overweight person can cause an increase in the production of oxidative stress (Vigriawan et al, 2022) and increase the synthesis of proinflammatory cytokines, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and IL-1β.…”