The combination of IL-2 nanoparticles and Palbociclib enhances the anti-tumor immune response for colon cancer therapy
Di Wang,
Xiaoshuang Wang,
Yingyu Zhang
et al.
Abstract:Immunotherapy of tumors plays a pivotal role in the current treatment of cancer. While interleukin 2 (IL-2) demonstrated its efficacy as an immunotherapeutic drug in the early days, its short blood circulation time poses challenges in maintaining effective therapeutic concentrations. Additionally, IL-2’s activation of regulatory T cells can counteract its anti-cancer effects. Therefore, the primary goal of this study was to formulate IL-2-carrying nanoparticles via boron-nitrogen coordination between methoxy p… Show more
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