The Combination of Glycolic Acid Peels With a Topical Regimen in the Treatment of Melasma in Dark-Skinned Patients: A Comparative Study

Sarkar, Rashmi; Kaur, Charandeep; Bhalla, Mala; Kanwar, Amrinder J.

doi:10.1046/j.1524-4725.2002.02034.x

Cited by 95 publications

(87 citation statements)

References 18 publications

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“…This study demonstrated that glycolic acid peels can enhance the efficacy of topical regimens. This enhanced efficacy had previously been observed with the combined use of glycolic acid peels and modified Kligman's formula (hydroquinone 5%, tretinoin 0Á05% and hydrocortisone acetate 1% in a cream) 26 as well as with glycolic acid peels and 4%…”

Section: Glycolic Acid and Melasmasupporting

confidence: 58%

Chemical peeling in ethnic skin: an update

2013

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SummaryWith the growth of cosmetic dermatology worldwide, treatments that are effective against skin diseases and augment beauty without prolonged recovery periods, or exposing patients to the risks of surgery, are increasing in popularity. Chemical peels are a commonly used, fast, safe and effective clinic room treatment that may be used for cosmetic purposes, such as for fine lines and photoageing, but also as primary or adjunct therapies for acne, pigmentary disorders and scarring. Clinicians are faced with specific challenges when using peels on ethnic skin (skin of colour). The higher risk of postinflammatory dyschromias and abnormal scarring makes peels potentially disfiguring. Clinicians should therefore have a sound knowledge of the various peels available and their safety in ethnic skin. This article aims to review the background, classification, various preparations, indications, patient assessment and complications of using chemical peels in ethnic skin.What's already known about this topic?• Chemical peels are efficacious therapeutic interventions for many skin disorders.• Many peels exist; however, not all are safe for use in ethnic skin.• Darker skin types have an increased risk of adverse events from chemical peeling such as pigmentary disorders. What does this study add?• This is an up-to-date review of the various peeling agents and their indications for use in ethnic skin.• It provides a summary of newer peeling agents.• It gives practical tips on performing chemical peeling safely and effectively in ethnic skin.

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Section: Glycolic Acid and Melasmasupporting

confidence: 58%

Chemical peeling in ethnic skin: an update

2013

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“…Off late there has been a lot of interest in the hormonal imbalances as the cause of melasma. The mean age of presentation in our study was 39.9 years which is consistent with 38 years in a previous study conducted by Rashmi Sarkar et al 12 In our study, positive family history was noted in 53.3% patients which is consistent with the study conducted by Athar Moin et al who reported positive family history in 54.7%. 13 Patients having positive family history had an earlier age of onset.…”

Section: Discussionsupporting

confidence: 91%

Clinico Epidemiological and Biochemical Profile of Patients With Melasma

Chandravathi¹,

Soujanya²,

Karani³

2015

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“…Additionally, therapies that have shown at least some effectiveness in this condition are most commonly directed at either decreased production of melanin or improved degradation and elimination of the pigment. Until recently, these included topical preparations, such as bleaching agents [13], corticosteroids [14], and retinoids [15], as well as physical modalities, most commonly various chemical peels [16][17][18], dermabrasion [19], intense pulsed light [20], and ablative and non-ablative laser treatments [21][22][23]. However, the latter methods may result in significant epidermal damage, leading to stimulation of melanocytes at the periphery of the treatment area with subsequent post-inflammatory hyperpigmentation.…”

Section: Discussionmentioning

confidence: 99%

Histologic and ultrastructural analysis of melasma after fractional resurfacing

2008

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Background and Objective: Fractional photothermolysis is a popular treatment option for photodamaged skin and other cutaneous conditions. Recently, successful improvement in melasma has been achieved with this laser system. We undertook this study to evaluate the ultrastructural changes associated with fractional laser treatment of melasma. Study Design/Materials and Methods: Ten subjects with skin types III and IV and a clinical diagnosis of epidermal melasma were treated with a 1,550-nm erbium:-glass laser delivering light in a fractional manner (Fraxel SR 750, Reliant Technologies, Inc., Mountain View, CA) every 2 weeks for a total of four sessions. Biopsies were obtained from all subjects both before treatment and at 3 months following the final treatment. All biopsies were analyzed by light and electron microscopy for treatmentinduced changes. In addition, a secondary endpoint of the study was to assess for clinical improvement in melasma following fractional resurfacing. This assessment was performed by the investigator using pre-and post-treatment photographs. Results: Light microscopy on post-treatment specimens showed a relative decrease in melanocytes compared to the pre-treatment ones. Post-treatment electron microscopy revealed fewer melanocytes and a relative absence of melanin in the surrounding keratinocytes compared to pre-treatment specimens. In addition, six subjects with skin type III were determined to have good improvement, whereas four subjects with skin type IV had fair improvement, as assessed by the investigator. Conclusion: Post-treatment ultrastructural changes are consistent with an elimination process and may help to explain clinical improvement following laser treatment.

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The Combination of Glycolic Acid Peels With a Topical Regimen in the Treatment of Melasma in Dark-Skinned Patients: A Comparative Study

Cited by 95 publications

References 18 publications

Chemical peeling in ethnic skin: an update

Chemical peeling in ethnic skin: an update

Clinico Epidemiological and Biochemical Profile of Patients With Melasma

Histologic and ultrastructural analysis of melasma after fractional resurfacing

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