The combination of gemcitabine and ginsenoside Rh2 enhances the immune function of dendritic cells against pancreatic cancer via the CARD9-BCL10-MALT1 / NF-κB pathway

Li, Qing; He, Jialuo; Li, Senlin; Tian, Cheng; Yang, Jian; Yuan, Huimin; Lu, Yi; Fagone, Paolo; Nicoletti, Ferdinando; Xiang, Ming

doi:10.1016/j.clim.2022.109217

Cited by 12 publications

(7 citation statements)

References 66 publications

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“…All the operations were based on operational guidelines. According to the method of Li et al, 52 cell apoptosis was tested by a FITC-Annexin V apoptosis detection kit (BD Biosciences, Franklin, NJ, USA). MMP was detected using JC-1 molecular probes (Yeasen, Shanghai, China).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Eurochevalierines A–I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5

Zhang,

Li,

Zhang

et al. 2024

J. Agric. Food Chem.

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Nine new sesquiterpene alkaloids, eurochevalierines A−I (1−9), were separated from the rice cultures of the endophytic fungus Penicillium sp. HZ-5 originated from the fresh leaf of Hypericum wilsonii N. Robson. The structures' illumination was conducted by single-crystal X-ray diffraction, extensive spectroscopic analysis, alkaline hydrolysis reaction, and Snatzke's method. Importantly, the antitumor activities screen of these isolates indicated that 1 could suppress triple negative breast cancer (TNBC) cell proliferation and induce apoptosis, with an IC 50 value of 5.4 μM, which is comparable to the positive control docetaxel (DXT). Flow cytometry experiments mentioned that compound 1 significantly reduced mitochondrial membrane potential (MMP) of TNBC cells. In addition, 1 could activate caspase-3 and elevated the levels of reactive oxygen species (ROS) and expressions of suppressive cytokines and chemokines. Further Western blot analysis showed that 1 could selectively induce mitochondriadependent apoptosis in TNBC cells via the BAX/BCL-2 pathway. Remarkably, these finding provide a new natural product skeleton for the treatment of TNBC.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Eurochevalierines A–I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5

Zhang,

Li,

Zhang

et al. 2024

J. Agric. Food Chem.

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“…Rg3 has the potential to be important in the field of tumor immunity due to its ability to increase macrophage phagocytic activity and stimulate Th1 immune responses [41]. Rh2, on the other hand, has demonstrated the ability to enhance immune responses while minimizing chemotherapy-induced immunosuppression [42,43]. In addition, the PPD-type ginsenosides Rb1, Rb2, Rc, and Rd have demonstrated immunostimulatory effects by increasing antibody titers, cytokine production, and lymphocyte proliferation.…”

Section: Ginseng and Immunitymentioning

confidence: 99%

The Potential of Korean Bioactive Substances and Functional Foods for Immune Enhancement

Kim,

Lee

2024

IJMS

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In this review, we explore the immunomodulatory properties of Korean foods, focusing on ginseng and fermented foods. One notable example is Korean red ginseng, known for its immune system-regulating effects attributed to the active ingredient, ginsenoside. Ginsenoside stimulates immune cells, enhancing immune function and suppressing inflammatory responses. With a long history, Korean red ginseng has demonstrated therapeutic effects against various diseases. Additionally, Korean fermented foods like kimchi, doenjang, chongkukjang, gochujang, vinegar, and jangajji provide diverse nutrients and bioactive substances, contributing to immune system enhancement. Moreover, traditional Korean natural herbs such as Cirsium setidens Nakai, Gomchwi, Beak-Jak-Yak, etc. possess immune-boosting properties and are used in various Korean foods. By incorporating these foods into one’s diet, one can strengthen their immune system, positively impacting their overall health and well-being.

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“…Relevant studies have shown that GRh2 combined with GEM (GEM-Rh2) affects pancreatic cancer cells and activated dendritic cells (DCs) by regulating the BCL10-MALT1/NF-κB pathway, with a significant increase in the number of DCs. The key target of DC function enhancement, central articulation protein caspase recruitment domain-containing protein 9, a key target of DC function enhancement, was significantly upregulated, and GRh2 enhanced the efficacy of GEM, providing a new therapeutic strategy and option for the “hot-cold” transformation of tumors ( 20 ).…”

Section: Chinese Herb Monomermentioning

confidence: 99%

Integrating Chinese medicine into mainstream cancer therapies: a promising future

Ni,

Xue,

Wang

et al. 2024

Front. Oncol.

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Malignant tumors are complex systemic chronic diseases and one of the major causes of human mortality. Targeted therapy, chemotherapy, immunotherapy, and radiotherapy are examples of mainstream allopathic medicine treatments that effective for intermediate and advanced malignant tumors. The ongoing use of conventional allopathic medicine has resulted in adverse responses and drug resistance, which have hampered its efficacy. As an important component of complementary and alternative medicine, Chinese medicine has been found to have antitumor effects and has played an important role in enhancing the therapeutic sensitivity of mainstream allopathic medicine, reducing the incidence of adverse events and improving immune-related functions. The combined application of adjuvant Chinese medicine and mainstream allopathic medicine has begun to gain acceptance and is gradually used in the field of antitumor therapy. Traditional natural medicines and their active ingredients, as well as Chinese patent medicines, have been proven to have excellent therapeutic efficacy and good safety in the treatment of various malignant tumors. This paper focuses on the mechanism of action and research progress of combining the above drugs with mainstream allopathic medicine to increase therapeutic sensitivity, alleviate drug resistance, reduce adverse reactions, and improve the body’s immune function. To encourage the clinical development and use of Chinese herb adjuvant therapy as well as to provide ideas and information for creating safer and more effective anticancer medication combinations, the significant functions of Chinese herb therapies as adjuvant therapies for cancer treatment are described in detail.

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The combination of gemcitabine and ginsenoside Rh2 enhances the immune function of dendritic cells against pancreatic cancer via the CARD9-BCL10-MALT1 / NF-κB pathway

Cited by 12 publications

References 66 publications

Eurochevalierines A–I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5

Eurochevalierines A–I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5

The Potential of Korean Bioactive Substances and Functional Foods for Immune Enhancement

Integrating Chinese medicine into mainstream cancer therapies: a promising future

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