The combination of fecal calprotectin with ESR, CRP and albumin discriminates more accurately children with Crohn’s disease

Daniluk, Urszula; Daniluk, Jarosław; Krasnodebska, Milena; Łotowska, Joanna Maria; Sobaniec-Łotowska, M; Lebensztejn, Dariusz Marek

doi:10.1016/j.advms.2018.08.001

Cited by 37 publications

(28 citation statements)

References 24 publications

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“…The diagnostic management takes time and requires performing invasive endoscopic procedures. On the other hand, serum and fecal markers of inflammation are insufficient for discriminating between IBD and other intestinal inflammatory diseases [ 1 , 2 ]. Recently, the applications of some novel techniques such as lipidomics or metabolomics have shown promising results indicating lipid metabolism in IBD pathology and enabling the identification of potential biomarkers [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Sphingolipid Analysis Indicate Lactosylceramide as a Potential Biomarker of Inflammatory Bowel Disease in Children

et al. 2020

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An altered ceramide composition in patients with inflammatory bowel disease (IBD) has been reported recently. The aim of this study was to evaluate the concentrations of sphingolipids in the serum of treatment-naive children with newly diagnosed IBD and to determine the diagnostic value of the tested lipids in pediatric IBD. The concentrations of sphingolipids in serum samples were evaluated using a quantitative method, an ultra-high-performance liquid chromatography-tandem mass spectrometry in children with Crohn’s disease (CD) (n=34), ulcerative colitis (UC) (n = 39), and controls (Ctr) (n = 24). Among the study groups, the most significant differences in concentrations were noted for C16:0-LacCer, especially in children with CD compared to Ctr or even to UC. Additionally, the relevant increase in C20:0-Cer and C18:1-Cer concentrations were detected in both IBD groups compared to Ctr. The enhanced C24:0-Cer level was observed only in UC, while C18:0-Cer only in the CD group. The highest area under the curve (AUC), specificity, and sensitivity were determined for C16:0-LacCer in CD diagnosis. Our results suggest that the serum LacC16-Cer may be a potential biomarker that distinguishes children with IBD from healthy controls and differentiates IBD subtypes. In addition, C20:0-Cer and C18:0-Cer levels also seem to be closely connected with IBD.

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Section: Introductionmentioning

confidence: 99%

Sphingolipid Analysis Indicate Lactosylceramide as a Potential Biomarker of Inflammatory Bowel Disease in Children

et al. 2020

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“…Based on literature overview, FC measurement in children was valuable in the diagnostics of IBD, infectious diarrhoea, GI complications in juvenile idiopathic arthritis, NEC, colonic polyps, non-steroidal anti-inflammatory drug-induced enteropathy, cystic fibrosis, and follow-up in coeliac disease [45,46]. Until now its most significant role is focused on diagnosis, the monitoring of remission and mucosal healing, and in the prediction of relapse in paediatric IBD.…”

Section: Faecal Calprotectinmentioning

confidence: 99%

“…Nevertheless, a growing body of clinical data suggest that FC is a valuable test for FA diagnostics in children [23,[45][46][47][48]. Waligora-Dupriet et al found that the level of FC in infants with FA was twice that of those without FA [45].…”

Section: Faecal Calprotectinmentioning

confidence: 99%

Biomarkers of intestinal epithelial damage in children with food allergies

Rycyk¹,

Lebensztejn²,

Cudowska³

2019

polp

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Food allergy has a significant negative impact on patients and their families, and it has become an important public health problem. Currently used diagnostic methods, such as skin prick tests (SPT) and determination of specific immunoglobulins E (sIgE), present limited sensitivity and specificity. Therefore, new tools are expected to improve the accuracy of the diagnostic work-up. A recent hypothesis of allergic reactions indicates a primary role of dysregulation of the epithelial barrier, which pioneers the role of biomarkers of intestinal damage in food allergy. The objective of this paper is to present the currently most promising biomarkers for the diagnosis, prognosis, and management of food allergy in children.

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“…In comparison, fecal biomarkers are especially promising due to ease of collection, good correlation with the severity of inflammation in the intestinal wall (their place of origin), and specificity for intestine inflammation. Fecal calprotectin (fCal) has already found a reliable place in gastroenterology to diagnose and monitor inflammatory diseases [ 11 ]. Studies on pathophysiology of an allergic reaction have indicated the potential role of eosinophil-derived neurotoxin (EDN), representing the activation and degranulation of eosinophils and tumor necrosis factor α (TNFα) involved in the process of intestinal epithelial cell damage, increased intestinal permeability, and mucosal infiltration by leukocytes [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Eosinophil-Derived Neurotoxin, Tumor Necrosis Factor Alpha, and Calprotectin as Non-Invasive Biomarkers of Food Protein-Induced Allergic Proctocolitis in Infants

Rycyk

Cudowska

Lebensztejn

2020

JCM

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Diagnosis of non-IgE mediated food allergy presents a special challenge due to lack of a single, non-invasive diagnostic method. We selected three fecal biomarkers of allergic inflammation of gastrointestinal origin in order to improve the diagnostic process. Twenty-seven infants with symptoms of hematochezia were prospectively enrolled into this study. All patients underwent a complete differential diagnosis of rectal bleeding. Non-IgE mediated food allergy was confirmed by an open, oral food challenge. The control group included twenty-five infants with functional gastrointestinal disorders. Eosinophil-derived neurotoxin (EDN), tumor necrosis factor alpha (TNFα), and calprotectin concentration were measured in stools of all children by enzyme-linked immunosorbent assays (ELISA) using commercial kits. Median eosinophil-derived neurotoxin and calprotectin fecal levels were significantly higher in the study group than in the control group (p < 0.05). The difference of fecal tumor necrosis factor alpha concentration between both groups was not statistically significant (p > 0.05). The best diagnostic performance was reached in a combination of fecal calprotectin (fCal) and EDN i.e., 88.9% and 84%, respectively. Fecal EDN and fCAl are reliable tools in differentiating between food protein-induced allergic proctocolitis and gastrointestinal functional disorders in infants.

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The combination of fecal calprotectin with ESR, CRP and albumin discriminates more accurately children with Crohn’s disease

Cited by 37 publications

References 24 publications

Sphingolipid Analysis Indicate Lactosylceramide as a Potential Biomarker of Inflammatory Bowel Disease in Children

Sphingolipid Analysis Indicate Lactosylceramide as a Potential Biomarker of Inflammatory Bowel Disease in Children

Biomarkers of intestinal epithelial damage in children with food allergies

Eosinophil-Derived Neurotoxin, Tumor Necrosis Factor Alpha, and Calprotectin as Non-Invasive Biomarkers of Food Protein-Induced Allergic Proctocolitis in Infants

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