The combination of Cytokines and albendazole therapy for prophylaxis and treatment of experimental/hydatid cyst

Rahdar, Mahmoud; Rafiei, Abdollah; Nouroozi, Rouhollah Valipour

doi:10.1016/j.actatropica.2019.105206

Cited by 10 publications

(5 citation statements)

References 23 publications

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“…There is no consensus on how long to continue this treatment. Besides, several experimental studies have demonstrated the superiority of the combination of chemotherapy and cytokines over albendazole alone (22). In our center, a medical habit of maintaining Albendazole treatment for at least 12 months was respected in all patients.…”

Section: Resultsmentioning

confidence: 91%

Hydatid cysts of the liver rupture into the peritoneal cavity: Fifteen cases and review of the literature

Mejri

Arfaoui

Saad

et al. 2021

Preprint

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BackgroundHydatid cyst is an infectious disease caused mainly by E. Granulosus, which is generally considered benign, however, the rupture of the hepatic Hydatid Cyst to the abdominal cavity is a life-threatening incident that requires urgent and multidisciplinary management (emergency physician, radiologists, aneasthetists and surgeons). This study aims to describe the various clinical and paraclinical features of ruptured liver hydatid cyst in the peritoneal cavity, and to detail the appropriate treatment.Materials and MethodsFifteen cases of ruptured liver hydatid cyst into the abdominal cavity that underwent urgent surgery were collected over a period of eight years. Results There were nine men and six women. The average age was 38 years. Two patients were admitted with abdominal trauma. All patients presented with acute abdominal pain. Only one patient had anaphylactic shock. Abdominal ultrasound showed discontinuous cyst wall and intraperitoneal fluid in 100% of cases. Abdominal computed tomography (CT) showed discontinuous cyst wall with intraperitoneal fluid in 100% of cases. Intraoperatively, the intraperitoneal fluid was clear in thirteen cases and purulent in two. All patients underwent unroofing procedure associated with intra-operative peritoneal lavage and external drainage. The mean hospital stay was 6.11 days and the mean follow-up was 19 months. No case of recurrence was reported among the patients.ConclusionRupture of a hydatid cyst in the abdominal cavity should be considered as a differential diagnosis in every case of an acute abdominal pain, especially in endemic areas and in presence of an allergic reaction or signs of anaphylactic shock. Combined medical and surgical care starting in the emergency room is the only guarantee of a good outcome.

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Section: Resultsmentioning

confidence: 91%

Hydatid cysts of the liver rupture into the peritoneal cavity: Fifteen cases and review of the literature

Mejri

Arfaoui

Saad

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…However, the efficacy of both drugs is poor in approximately 40% of patients due to the drawbacks of weak intestinal absorption and low blood levels ( 9 , 10 ). Patients with spinal CE have even lower local blood concentrations of ABZ and MBZ, these drugs are even less efficacious in spinal-CE patients than in liver and lung CE patients due to the presence of a bony barrier at parasitization site ( 11 ). Moreover, exploratory research into the pharmacological treatment of CE has been limited to intra-abdominal parasites, while basic research on bone or spinal CE is still lacking.…”

Section: Introductionmentioning

confidence: 99%

α-Mangostin Exhibits a Therapeutic Effect on Spinal Cystic Echinococcosis by Affecting Glutamine Metabolism

Wang

Sun

Wang

et al. 2023

Antimicrob Agents Chemother

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“…Besides, several experimental studies have demonstrated the superiority of the combination of chemotherapy and cytokines over albendazole alone (22). In our center, a medical habit of maintaining Albendazole treatment for at least 12 months was respected in all patients.…”

Section: Discussionmentioning

confidence: 91%

Hydatid Cysts of the Liver Rupture into the Peritoneal Cavity: Fifteen Cases and Review of the Literature

Mejri

Arfaoui

Saad

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundHydatid cyst is a parasitic infection caused mainly by E. Granulosus, which is generally considered benign. However, the hepatic Hydatid Cyst rupture in the abdominal cavity is a life-threatening incident that requires urgent and multidisciplinary management (emergency physician, radiologists, anesthetists, and surgeons). This study describes clinical and paraclinical liver hydatid cyst rupture in the peritoneal cavity and details the appropriate treatment.Materials and MethodsFifteen liver hydatid cyst cases ruptured into the abdominal cavity that underwent urgent surgery were collected over eight years. Results There were nine men and six women. Patients' age ranged from 14 to 59 years, with an age average of 38 years. Two patients were admitted with abdominal trauma, and acute abdominal pain was the common consultation's reason. Only one patient had an anaphylactic shock. Both abdominal ultrasound and CT scan showed discontinuous cyst wall and intraperitoneal fluid in 100% of cases. Intraoperatively, the intraperitoneal effusion was clear in thirteen cases and purulent in two. All patients underwent unroofing procedure associated with intra-operative peritoneal lavage and external drainage. The mean hospital stay was 6.11 days, and the mean follow-up was 19 months. No case of recurrence was reported among the patients.ConclusionRupture of a hydatid cyst in the abdominal cavity should be evoked in front of acute abdominal pain, especially in endemic areas, and in the presence of an allergic reaction or anaphylactic shock signs. Combined surgical and medical care starting in the emergency room is the only guarantee of a good outcome.

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The combination of Cytokines and albendazole therapy for prophylaxis and treatment of experimental/hydatid cyst

Cited by 10 publications

References 23 publications

Hydatid cysts of the liver rupture into the peritoneal cavity: Fifteen cases and review of the literature

Hydatid cysts of the liver rupture into the peritoneal cavity: Fifteen cases and review of the literature

α-Mangostin Exhibits a Therapeutic Effect on Spinal Cystic Echinococcosis by Affecting Glutamine Metabolism

Hydatid Cysts of the Liver Rupture into the Peritoneal Cavity: Fifteen Cases and Review of the Literature

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