The Combination of Bifidobacterium breve and Three Prebiotic Oligosaccharides Modifies Gut Immune and Endocrine Functions in Neonatal Mice

Izumi, Hirohisa; Ehara, Tatsuya; Sugahara, Hirosuke; Matsubara, Takeshi; Mitsuyama, Eri; Nakazato, Yuki; Tsuda, Muneya; Shimizu, Takashi; Odamaki, Toshitaka; Xiao, Jin‐zhong; Takeda, Yasuhiro

doi:10.1093/jn/nxy248

Cited by 14 publications

(7 citation statements)

References 42 publications

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“…For instance, Xu et al (2021) [ 33 ] found that the increased concentrations of serum IgG and IgA were positively correlated with the increased abundance of intestinal Lactobacillus . Furthermore, the by-products produced from bifidobacterial carbohydrate metabolism act as vectors that directly and indirectly trigger the mucosa-associated immune cells to enhance the immune system of the host [ 34 , 35 ]. In the present study, we found that calves supplemented with NaH had a higher concentration of immunoglobulin in the serum and abundances of Bifidobacterium and Lactobacillus in the fecal samples.…”

Section: Discussionmentioning

confidence: 99%

Influence of Sodium Humate on the Growth Performance, Diarrhea Incidence, Blood Parameters, and Fecal Microflora of Pre-Weaned Dairy Calves

Wang

You

et al. 2022

Animals

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This study aimed to evaluate the effects of the administration of sodium humate (NaH) on the growth performance, diarrhea incidence, and fecal microflora of pre-weaned Holstein calves. In a 53-day experiment, forty healthy newborn female calves were randomly allocated to the following four treatment groups: (1) control (basal diet); (2) 1-gram NaH (basal diet extra orally supplemented with 1 g of NaH dissolved in 100 mL of milk or milk replacer daily); (3) 3-gram NaH (basal diet extra orally supplemented with 3 g of NaH dissolved in 100 mL of milk or milk replacer daily); and (4) 5-gram NaH (basal diet extra orally supplemented with 5 g of NaH dissolved in 100 mL of milk or milk replacer daily). NaH was mixed with milk (d 2–20) or milk replacer (d 21–53). Calves in the 5-gram NaH group had a higher ADG during d 1 to 21 and d 21 to 53 than the other groups did (p < 0.05). Fecal scores and diarrheal incidence were significantly lower in the 3-gram and 5-gram NaH groups than the 1-gram NaH and control groups during d 1 to 20 (p < 0.05). The serum IgA, IgG and IL-4 concentrations, and T-SOD and T-AOC activities were higher, and the serum IL-6, TNF-α, D-lactic acid, and MDA concentrations were lower in the 5-gram NaH group than the control group (p < 0.05). Furthermore, NaH supplementation increased the abundances of Bifidobacterium and Lactobacillus but decreased the abundance of Escherichia coli in feces (p < 0.05). These encouraging findings indicated that supplementation with 5 g of NaH effectively improved the immune status, antioxidant capacity, and intestinal beneficial bacteria, and further improved the growth performance and reduced the diarrhea incidence of the pre-weaned dairy calves.

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Section: Discussionmentioning

confidence: 99%

Influence of Sodium Humate on the Growth Performance, Diarrhea Incidence, Blood Parameters, and Fecal Microflora of Pre-Weaned Dairy Calves

Wang

You

et al. 2022

Animals

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“…Several studies have demonstrated the potential role of B. breve (NCIMB8807, M-16V, AH1205) and B. longum AH1206 in improving the maturation of the intestinal immune system and promoting bifidobacterial colonization during early infancy [159][160][161][162][163][164]. An extensive transcriptomic regulation involving ≈4000 genes significantly upregulated in the intestinal epithelial cells was observed after 3 days of treatment of two-week-old mice with B. breve UCC2003, including key genes linked with epithelial barrier development, and driving transcriptomic alteration [159].…”

Section: Animal Modelsmentioning

confidence: 99%

“…An extensive transcriptomic regulation involving ≈4000 genes significantly upregulated in the intestinal epithelial cells was observed after 3 days of treatment of two-week-old mice with B. breve UCC2003, including key genes linked with epithelial barrier development, and driving transcriptomic alteration [159]. Additionally, an influence on the correct development of the mucosal immunity in early life was observed, by an enhancement of the homing process of naive T lymphocytes to the mesenteric lymph node, and the retention of activated lymphocytes in the intraepithelial compartment [160], reduced expression of inflammation-related genes in the colon [161], and an increased Treg proportion in the large intestine as well as enhanced gut immune and endocrine development in suckling mice [162,163]. [193] CFU: colony-forming units; d: days; DNFB: 2, 4-dinitrofluorobenzene; DSS: dextran sulfate sodium; f: female; FOS: fructooligosaccharides; GF: germ-free; GOS: galactooligosaccharides; HFD: high-fat diet; HPA: hypothalamic-pituitary-adrenal; m: male; n: sample size; n/a: not available; NEC: necrotizing enterocolitis; OVA: ovalbumin; RV: rotavirus; SD: Sprague-Dawley; SPF: specific-pathogen-free; w: weeks.…”

Section: Animal Modelsmentioning

confidence: 99%

Role of Bifidobacteria on Infant Health

et al. 2021

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Bifidobacteria are among the predominant microorganisms during infancy, being a dominant microbial group in the healthy breastfed infant and playing a crucial role in newborns and infant development. Not only the levels of the Bifidobacterium genus but also the profile and quantity of the different bifidobacterial species have been demonstrated to be of relevance to infant health. Although no definitive proof is available on the causal association, reduced levels of bifidobacteria are perhaps the most frequently observed alteration of the intestinal microbiota in infant diseases. Moreover, Bifidobacterium strains have been extensively studied by their probiotic attributes. This review compiles the available information about bifidobacterial composition and function since the beginning of life, describing different perinatal factors affecting them, and their implications on different health alterations in infancy. In addition, this review gathers exhaustive information about pre-clinical and clinical studies with Bifidobacterium strains as probiotics in neonates.

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“…Bifidobacterium breve UCC2003 has been reported to metabolize certain human milk oligosaccharides, as well as various other dietary glycans, such starch, raffinose, cellodextrins and galactooligosaccharides (Izumi, et al , 2019; James, et al , 2019a; James, et al , 2019b; Ruiz‐Aceituno et al , 2020). However, B. breve is generally not able to degrade and metabolize (complex) polysaccharides (O’Connell Motherway, et al , 2018).…”

Section: Introductionmentioning

confidence: 99%

Biochemical analysis of cross‐feeding behaviour between two common gut commensals when cultivated on plant‐derived arabinogalactan

Muñoz

James

Bottacini

et al. 2020

Microbial Biotechnology

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In this paper, we reveal and characterize cross-feeding behaviour between the common gut commensal Bacteroides cellulosilyticus (Baccell) and certain bifidobacterial strains, including Bifidobacterium breve UCC2003, when grown on a medium containing Larch Wood Arabinogalactan (LW-AG). We furthermore show that cross-feeding is dependent on the release of b-1,3galacto-di/trisaccharides (b-1,3-GOS), and identified that the bga gene cluster of B. breve UCC2003 allows b-1,3-GOS metabolism. The product of bgaB is presumed to be responsible for the import of b-1,3-GOS, while the bgaA gene product, a glycoside hydrolase family 2 member, was shown to hydrolyse both b-1,3galactobiose and b-1,3-galactotriose into galactose monomers. This study advances our understanding of strain-specific syntrophic interactions between two glycan degraders in the human gut in the presence of AG-type dietary polysaccharides.

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The Combination of Bifidobacterium breve and Three Prebiotic Oligosaccharides Modifies Gut Immune and Endocrine Functions in Neonatal Mice

Cited by 14 publications

References 42 publications

Influence of Sodium Humate on the Growth Performance, Diarrhea Incidence, Blood Parameters, and Fecal Microflora of Pre-Weaned Dairy Calves

Influence of Sodium Humate on the Growth Performance, Diarrhea Incidence, Blood Parameters, and Fecal Microflora of Pre-Weaned Dairy Calves

Role of Bifidobacteria on Infant Health

Biochemical analysis of cross‐feeding behaviour between two common gut commensals when cultivated on plant‐derived arabinogalactan

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