The Columnar-Lined Esophagus (Barrett Syndrome)—An Acquired Condition?

Mossberg, Sanford M.

doi:10.1016/s0016-5085(66)80127-0

Cited by 104 publications

(12 citation statements)

References 12 publications

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“…10 who had an ascending stricture. Such findings correspond with those of Goldman and Beckman (1960), who observed a stricture ascend over a seven-year period, and Mossberg (1966) who described the ascent of glandular epithelium during a period of 30 months.…”

Section: Treatmentsupporting

confidence: 91%

High peptic stricture of the oesophagus.

Davidson¹

1976

Thorax

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Davidson, J. S. (1976). Thorax, 31,[1][2][3][4][5][6][7][8][9][10][11][12][13][14]. High peptic sticture of the oesophagus. Fifty-seven patients with high peptic stricture and the lower oesophagus lined by columnar epithelium are considered from the clinical point of view. Information from 115 cases of low stricture is introduced for comparison. The average age of adult patients was 62 years with a sex incidence of 36 females to 21 males. There is little difference between the symptoms of high and low strictures. Radiologically, the majority of high strictures are short and smooth but other types are illustrated. Carcinoma and congenital mid-oesophageal web are considered in the differential diagnosis. There was an associated duodenal ulcer in 10% of cases. In six patients, a high stricture developed soon after an abdominal operation or period of recumbency. Two patients are illustrated showing the process of stricture formation. Four patients are described who had gastric-lined oesophagus but no ulceration or stricture. One patient had a Barrett ulcer in addition to a high stricture. A patient is described in whom the mucosa of the lower oesophagus appeared to be replaced by jejunal mucosa following oesophagojejunostomy. One patient is illustrated in whom a stricture was seen to ascend the oesophagus over a period of six years. Thirty-three patients were treated by dilatation and 24 by operation. Hernial repair is an effective form of treatment. Of 19 patients treated in this way, significant dysphagia persisted in two and slight dysphagia in one. The clinical findings are discussed in relation to the origin of columnar epithelium in the oesophagus.

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Section: Treatmentsupporting

confidence: 91%

High peptic stricture of the oesophagus.

Davidson¹

1976

Thorax

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Section: Discussionmentioning

confidence: 99%

“…This aberrant epithelium that develops in the distal esophagus is the site of a variety of lesions including ulceration, stricture, and adenocarcinoma [5,10,11]. It has now been widely recognized that Barrett's esophagus is an acquired condition that is likely to be caused by reflux of gastric content because of hiatal hernia [5,10,11]. Recent epidemiological study has shown an ethnic difference in the incidence of Barrett's esophagus, which is higher in Caucasians than in South Asians [12], and many explanations have been suggested for this difference.…”

Section: Discussionmentioning

confidence: 99%

Acute upper gastrointestinal bleeding from multiple Barrett's ulcers associated with metachronous multiple colorectal carcinomas

et al. 2006

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Although gastroesophageal reflux disease is sometimes associated with esophageal ulcer and/or mucosal erosion, acute upper gastrointestinal bleeding from an esophageal ulcer is uncommon. We report a case of acute gastrointestinal bleeding from one of multiple esophageal ulcers in extensive Barrett's esophagus in the postoperative period after low anterior resection performed for descending colon carcinoma. A 74-year-old Japanese woman had undergone sigmoid colon resection 6 years earlier. The patient had a history of repeated reflux esophagitis. She was referred to a local hospital for a simple health screening 5 years after surgery. The patient had noticed bloody stool and felt mild difficulty at defecation 2 weeks before admission. Lower gastrointestinal endoscopy performed at a local hospital revealed a type 2 tumor located approximately 15 cm from the anal verge, which was obviously the cause of the bloody stool and constipation. The patient was admitted to our hospital for surgical treatment. Ten days after the low anterior resection, upper gastrointestinal bleeding occurred. Upper gastrointestinal endoscopy revealed multiple ulcers in the lower esophagus, which had caused the bleeding. Endoscopic biopsy revealed that esophageal ulcer occurred in the Barrett's esophagus, extending 15 cm from the functional esophagogastric junction. This case highlights acute upper gastrointestinal bleeding from multiple Barrett's ulcers in extensive Barrett's epithelium occurring in the postoperative period of colorectal carcinoma, and indicates an association of Barrett's esophagus with metachronous multiple colon carcinoma.

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“…Sequential biopsies have shown that columnar epithelium can progressively replace squamous epithelium. 12 A characteristic of the mucin is that it is neutral type in most metaplastic epithelium, but sialomucins and sulfomucins were also present in over 70% of cases. [13][14][15] Irrespective of the type of epithelium, scattered endocrine cells were demonstrated in 90% of biopsy specimens by argyrophilic staining.…”

Section: Pathological Diagnosismentioning

confidence: 99%