The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma I: characteristics of patients enrolled and not enrolled COMS report no. 9

Hawkins, Barbara S.; Vine, Andrew K.; Willis, J. R.; Frueh, Béatrice E.; Kurtz, Ronald M.; Elner, Susan G.; Johnson, Mark W.; Sneed, Scott R.; Hayman, James A.; Lichter, Allen S.; McGinn, Cornelius J.; Robertson, Jeanne M.; Schoeppel, Sonja L.; Haken, R. Ten; Thompson, A. V.; Meyer, Karsten; Mártonyi, Csaba L.; Stanley, Sarah A.; Elner, Victor M.; Kincaid, Marilyn C.; Wolter, R. J.; Sternberg, Paul; Brown, J. M.; Aaberg, Thomas M.; Capone, Antonio; Wojno, Ted H.; Lim, Jennifer I.; Keller, James W.; Landry, Jace P.; Crocker, Ian; McLaren, Jay W.; Aguilera, C. A.; Butler, E. Brian; Klee, Katharina; Strongosky, D.; Gibbs, Danielle; Curtis, Luke; Fremstad, A.; Waldron, Rhonda; Ward, Aaron D.; Gilman, James; Myles, Richard A.; Swords, R.; Grossniklaus, Hans E.; Calhoun, F. Phinizy; Campbell, William; Jarrett, William H.; Hagler, William S.; Halpen, R. L.; Jones, N.; Schwaibold, Frederick P.; Wynn, K. J.; Mondalek, Peter M.; Degenhardt, G. A.; Hulsey, E. K.; Lee, D. H.; Aaron, Joann; Bolerjak, D.; McCart, S.; McCoy, Georgia A.; Thompson, Kimberly D.; Baxter, B. Timothy; Robinson, Barry; Wilson, K.; Schachat, Andrew P.; Doll, W T Jr; Greenberg, E. F.; Alexander, Marguerite F.; Sackett, C. S.; Goldberg, Morton F.; Hammer, Liat; Iliff, Nicholas T.; Lee, D. J.; Chun, Melissa W.; Jackson, J. F.; Iannito, J.; Lam, Wai Ching; Pollack, L.; DiBernardo, Cathy; Cain, Dennis; Emmert, David; George, Timothy; Zakov, Z. N.; Rice, Thomas A.; Hartnett, M. Elizabeth; Lichterman, Susan; Dempsey, Karen; Preseren, D.; Niffenegger, John H.; Novák, Michael; Pendergast, Scott D.; Singermann, L. J.; Weidenthal, Daniel T.; Zegarra, Hernando; Antoszyk, James H.; Shina, DC; Pillai, Kumar; Knight, D.; Coreno, K.

doi:10.1016/s0002-9394(98)00038-5

Cited by 87 publications

(9 citation statements)

References 20 publications

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“…In 1964, 19% of the enucleations due to uveal melanoma that were sent to the Institute of Pathology of the Armed Forces corresponded to a misdiagnosis. In 1984 it decreased to 1.4%, in 1990 it was 0.4% and in 1998 it was reported to be only 0.3% [4].…”

Section: Discussionmentioning

confidence: 90%

“…The improvement in accuracy is due to increased use of ophthalmoscopy, better recognition of lesions that simulate melanomas, and the development of the ocular ultrasound [4].…”

Section: Discussionmentioning

confidence: 99%

“…In the collaborative study of Ocular Melanoma [1] with eight years of follow-up of 6078 patients recruited with sizeable choroidal melanoma (with more than 17.2 mm in baseline diameter and 9.5 mm in height), 1003 patients were found to be eligible, and 97% of those were non-Hispanic whites, with an average age of 60 years, with no preference for sex [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Uveal melanoma represents less than 5% of all malignant melanomas [1] and leads to metastasis and death in 31% of the cases at five years [3].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Retinal detachment with a giant bleeding cyst, simulating a uveal melanoma — a case report

Ferreira

Rivera

Muñoz³

et al. 2021

Ophthalmol J

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BAckground: Pseudo-melanomas are a group of pathologies that can mimic melanoma. A retinal hemorrhagic macrocyst is a rare condition that can mimic choroidal melanoma. Diagnosing it accurately is important because of the difference in prognosis and treatment. Ocular ultrasound can be used to help differentiate between these similar conditions. cASE prESEntAtIon: We present a patient with a choroidal pseudo-melanoma diagnosed accurately and on time with the aid of an ocular ultrasound.

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Section: Discussionmentioning

confidence: 90%

“…The improvement in accuracy is due to increased use of ophthalmoscopy, better recognition of lesions that simulate melanomas, and the development of the ocular ultrasound [4].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Uveal melanoma represents less than 5% of all malignant melanomas [1] and leads to metastasis and death in 31% of the cases at five years [3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Retinal detachment with a giant bleeding cyst, simulating a uveal melanoma — a case report

Ferreira

Rivera

Muñoz³

et al. 2021

Ophthalmol J

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show abstract

“…Primary UM (pUM) originates predominantly in the capillary-rich uveal tract (i.e., the iris, ciliary body, and choroid), which facilitates metastasis through hematogenous dissemination of the tumor cells. UM metastases usually target the liver, but multiple metastases in other organs (e.g., lung and bone) also occur [ 5 ], with micrometastases capable of lying dormant and undetected for decades [ 6 ]. While immunotherapy has been beneficial for treating metastatic skin melanoma, it is well known that uveal and cutaneous melanomas differ in many ways [ 7 , 8 ], and no treatments currently exist to effectively treat metastatic UM [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Proteomics of Primary Uveal Melanoma: Insights into Metastasis and Protein Biomarkers

Jang

Crabb

et al. 2021

Cancers

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Uveal melanoma metastases are lethal and remain incurable. A quantitative proteomic analysis of 53 metastasizing and 47 non-metastasizing primary uveal melanoma (pUM) was pursued for insights into UM metastasis and protein biomarkers. The metastatic status of the pUM specimens was defined based on clinical data, survival histories, prognostic analyses, and liver histopathology. LC MS/MS iTRAQ technology, the Mascot search engine, and the UniProt human database were used to identify and quantify pUM proteins relative to the normal choroid excised from UM donor eyes. The determined proteomes of all 100 tumors were very similar, encompassing a total of 3935 pUM proteins. Proteins differentially expressed (DE) between metastasizing and non-metastasizing pUM (n = 402) were employed in bioinformatic analyses that predicted significant differences in the immune system between metastasizing and non-metastasizing pUM. The immune proteins (n = 778) identified in this study support the immune-suppressive nature and low abundance of immune checkpoint regulators in pUM, and suggest CDH1, HLA-DPA1, and several DE immune kinases and phosphatases as possible candidates for immune therapy checkpoint blockade. Prediction modeling identified 32 proteins capable of predicting metastasizing versus non-metastasizing pUM with 93% discriminatory accuracy, supporting the potential for protein-based prognostic methods for detecting UM metastasis.

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Estimates of Ocular and Visual Retention Following Treatment of Extra-Large Uveal Melanomas by Proton Beam Radiotherapy

Conway

Poothullil²,

Daftari³

et al. 2006

Arch Ophthalmol

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The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma I: characteristics of patients enrolled and not enrolled COMS report no. 9

Cited by 87 publications

References 20 publications

Retinal detachment with a giant bleeding cyst, simulating a uveal melanoma — a case report

Retinal detachment with a giant bleeding cyst, simulating a uveal melanoma — a case report

Proteomics of Primary Uveal Melanoma: Insights into Metastasis and Protein Biomarkers

Estimates of Ocular and Visual Retention Following Treatment of Extra-Large Uveal Melanomas by Proton Beam Radiotherapy

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