The colitis of Behcet's disease: A separate entity?

Smith, Gerald E.; Kime, Lynn R.; Pitcher, J. Loren

doi:10.1007/bf01072445

Cited by 73 publications

(6 citation statements)

References 40 publications

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“…It is, however , difficult to distinguish Behcet ' s from Crohn' s colitis on endoscopic appea rance and muco sal biop sy because in both cond itions there is focal ulceration , discontinuou s bowel involvement , and overlap of some histological features. Histological examination of the two resected colons failed to show any feature s of Crohn' s disease but did reveal changes consistent with those previously reported for intestinal Beheel' s syndrome (3,18,19) although the small and large vess els did not show evidence of an accompan ying vasc ulitis.…”

Section: Discussionsupporting

confidence: 87%

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Infantile Colitis

Chong,

Wright,

Nishigame

et al. 1988

J. pediatr. gastroenterol. nutr.

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Summary:A brother and sister of first cousin Pakistani parents presented with recurrent mouth ulcers and chronic diarrhoea in the neonatal period. Diarrhoea persisted in spite of treatment with oral prednisolone and sulphasalazine. Both children required subtotal colectomy with ileostomy. Histopathology of the resected colons was virtually identical and showed multiple deep “flask”‐shaped ulcers, often penetrating to the serosa, in the presence of chronic inflammation, but without any of the characteristic histological features of Crohn's disease. The appearance closely resembled the colitis of Behcet's syndrome. Both children (aged 6 and 3.5 years, respectively) have continued to have recurrent perianal disease with intermittent bloody diarrhoea since the operation. Apart from the initial symptoms of oral aphthous ulcerations in both children, no other major criteria have developed so far. Intestinal Behcet's syndrome should be considered in the differential diagnosis of chronic inflammatory bowel disease in childhood.

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Section: Discussionsupporting

confidence: 87%

“…Intestinal involvement in Behcet ' s syndrome is being increasingly recogni sed (3,4) and there have been rec ent cases (5) from Japan of incomplete disease with intestinal involvement occurring in childhood. We report two siblings of Pakistani parentage who presented with mouth ulcers and a coliti s 0 indeterminate type in the neon atal period.…”

mentioning

confidence: 99%

Infantile Colitis

Chong,

Wright,

Nishigame

et al. 1988

J. pediatr. gastroenterol. nutr.

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“…Volcano-type ulcers had a less favorable response to medical treatment, a more frequent requirement for surgery, and more frequent recurrences than the other two types [53]. Rarely, there are vesicular lesions or single rectal ulcers with otherwise normal mucosa [54]. Intestinal permeability is increased as measured by the urinary excretion of orally ingested chromium-51 ethylene diamine tetraacetic acid (EDTA) in both BD and in disease controls compared to healthy individuals [55].…”

Section: Gastrointestinal (Gi) Diseasementioning

confidence: 98%

Gastrointestinal Manifestations of Behçet’s Disease

Ebert

2008

Dig Dis Sci

113

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Behçet's disease is a rare vasculitis diagnosed by the presence of recurrent oral ulcers and two of the following: genital ulcers, typical eye lesions, typical skin lesions, and positive pathergy test. It is most commonly seen in countries along the ancient silk road from Eastern Asia to the Mediterranean Basin. Young adults between the second and fourth decades of life are mainly affected, with abdominal pain being the most common symptom. The ileocecal region is most commonly affected, with ulcerations that may penetrate or perforate. Rarely, the esophagus and stomach may have ulcerations. Bowel wall thickening is the most common finding on computed tomography (CT) scan. Pathology shows a vasculitis mainly involving the small veins or, alternatively, nonspecific inflammation. Corticosteroids, with or without other immunosuppressive drugs, are used for severe eye disease. Their use in intestinal disease is largely empirical. Surgery may be required for perforation. Behçet's disease runs a chronic, unpredictable course with exacerbations and remissions which decrease in frequency and severity over time. Death is mainly due to major vessel disease and neurological involvement.

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“…Colonic lesions have been properly documented in only fourteen earlier cases. The literature on these was recently reviewed by Smith, Kime and Pitcher (1973). It was noted that all these patients had left-sided colitis with associated rectal lesions.…”

Section: Discussionmentioning

confidence: 99%