The Colistin-Only-Sensitive Brazilian Pseudomonas aeruginosa Clone SP (Sequence Type 277) Is Spread Worldwide

Hygienemaßnahmen bei Infektionen oder Besiedlung mit multiresistenten gramnegativen Stäbchen

“…Dies wird durch Daten zur Verbreitung Carbapenem-resistenter P. aerugi nosa-Isolate unterstützt, die zeigten, dass die Verbreitung VIM-und IMP-Carbapenemase tragender Stämme auf wenige klonale Gruppen zurückgeführt werden kann [94][95][96]. Auch Untersuchungen in einzelnen Kliniken oder Regionen zeigen, dass in der endemischen Situation einzelne Stämme vorherrschen und verbreitet werden können [97,98].…”

“…Andererseits wurden auch Situationen beschrieben, in denen die Epidemiologie durch genetische Heterogenität gekennzeichnet war [99,100]. Von den über 900 verzeichneten multilocus sequence typing (MLST) Typen von P. aeruginosa scheinen nur etwas mehr als 10 Typen pandemische Eigenschaften, mit Nachweisen über mehrere Jahre in verschiedenen Ländern zu haben [94]. …”

Detection of SPM and IMP metallo-β-lactamases in clinical specimens of Pseudomonas aeruginosa from a Brazilian public tertiary hospital

“…7,8,14 Investigating MBL-encoding genes, we found isolates carrying bla SPM and bla IMP genes that together correspond to 29.8% of evaluated samples. In Brazil, the dissemination of P. aeruginosa carrying bla SPM gene has been reported throughout from several regions, 15,16 and SPM is the prevalent MBL among the isolates, although other enzymes have also been described, but with low frequency. 9,10,16,17 SPM carbapenemase was the main mechanism that conferred resistance to ceftazidime on ceftazidime-resistant P. aeruginosa isolated from bloodstream infections.…”

“…6 The contention of MBL producing P. aeruginosa is highly recommended, because patient-to-patient transmission may lead these strains to be endemic in such institution 3 or among different hospitals. [15][16][17] In Brazil, Gales et al 16 reported the spreading of bla SPMproducing P. aeruginosa clone throughout the country. The non-centralized distribution of positive MBL P. aeruginosa from Hospital of Botucatu Medical School (i.e., the recovering of MBL P. aeruginosa from hospitalized patients from several wards) suggests the non-clonal spreading of P. aeruginosa strains, although further molecular analyses are necessary to confirm this hypothesis.…”

“…It is worthwhile to emphasize that, after restricted by more than ten years to Brazilian hospitals, SPM seems to become a global challenge, 15,20 warning for the role of human traffic in spreading MBL genes. 6,20 …”