The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome

Firmann, Mathieu; Mayor, Vladimir; Marques‐Vidal, Pedro; Bochud, Murielle; Pécoud, A; Hayoz, Daniel; Paccaud, Fred; Preisig, Martin; Song, Kijoung; Yuan, Xin; Danoff, Theodore M.; Stirnadel, Heide A.; Waterworth, Dawn; Mooser, Vincent; Waeber, Gérard; Vollenweider, Péter

doi:10.1186/1471-2261-8-6

Cited by 587 publications

(619 citation statements)

References 32 publications

(30 reference statements)

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“…Chi-square or Fisher's exact test were used to assess differences between proportions. As gender (Stowe et al, 2010), leisure-time physical activity (Fischer et al, 2007), smoking (Fröhlich et al, 2003) and antibiotic/anti-inflammatory drugs have been associated with cytokine levels, they were included in all multivariate models. Multivariate analysis was performed on dosable (above lower limits of detection) log-transformed values of IL-1b, IL-6, TNF-a and CRP, and the results were expressed as exponentiated-adjusted mean±standard error.…”

Section: Resultsmentioning

confidence: 99%

The association between inflammatory biomarkers and metabolically healthy obesity depends of the definition used

et al. 2011

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Background/Objectives: To assess the distribution of interleukin (IL)-1b, IL-6, tumour necrosis factor (TNF)-a and C-reactive protein (CRP) according to the different definitions of metabolically healthy obesity (MHO). Subjects/Methods: A total of 881 obese (body mass index (BMI) X30 kg/m 2 ) subjects derived from the population-based CoLaus Study participated in this study. MHO was defined using six sets of criteria including different combinations of waist, blood pressure, total high-density lipoprotein cholesterol or low-density lipoprotein -cholesterol, triglycerides, fasting glucose, homeostasis model, high-sensitivity CRP, and personal history of cardiovascular, respiratory or metabolic diseases. IL-1b, IL-6 and TNF-a were assessed by multiplexed flow cytometric assay. CRP was assessed by immunoassay. Results: On bivariate analysis some, but not all, definitions of MHO led to significantly lower levels of IL-6, TNF-a and CRP compared with non-MH obese subjects. Most of these differences became nonsignificant after multivariate analysis. An posteriori analysis showed a statistical power between 9 and 79%, depending on the inflammatory biomarker and MHO definition considered. Further increasing sample size to overweight þ obese individuals (BMIX25 kg/m 2 , n ¼ 2917) showed metabolically healthy status to be significantly associated with lower levels of CRP, while no association was found for IL-1b. Significantly lower IL-6 and TNF-a levels were also found with some but not all MHO definitions, the differences in IL-6 becoming nonsignificant after adjusting for abdominal obesity or percent body fat. Conclusions: MHO individuals present with decreased levels of CRP and, depending on MHO definition, also with decreased levels in IL-6 and TNF-a. Conversely, no association with IL-1b levels was found.

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Section: Resultsmentioning

confidence: 99%

The association between inflammatory biomarkers and metabolically healthy obesity depends of the definition used

et al. 2011

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“…The primary aim of the CoLaus study was to assess the prevalence of cardiovascular risk factors in the population of Lausanne, Switzerland (17). The CoLaus study complied with the Declaration of Helsinki and was approved by the local institutional ethics committees.…”

Section: Colaus Studymentioning

confidence: 99%

“…The sampling procedure of the CoLaus study has been described elsewhere (17). Briefly, the CoLaus study was population-based and included participants aged 35-75 years.…”

Section: Colaus Studymentioning

confidence: 99%

Serum 25-Hydroxyvitamin D Level and Kidney Function Decline in a Swiss General Adult Population

Guessous

McClellan

Kleinbaum

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives Molecular evidence suggests that levels of vitamin D are associated with kidney function loss. Still, population-based studies are limited and few have considered the potential confounding effect of baseline kidney function. This study evaluated the association of serum 25-hydroxyvitamin D with change in eGFR, rapid eGFR decline, and incidence of CKD and albuminuria.Design, setting, participants, & measurements Baseline (2003Baseline ( -2006 and 5.5-year follow-up data from a Swiss adult general population were used to evaluate the association of serum 25-hydroxyvitamin D with change in eGFR, rapid eGFR decline (annual loss .3 ml/min per 1.73 m 2 ), and incidence of CKD and albuminuria. Serum 25-hydroxyvitamin D was measured at baseline using liquid chromatography-tandem mass spectrometry. eGFR and albuminuria were collected at baseline and follow-up. Multivariate linear and logistic regression models were used considering potential confounding factors.Results Among the 4280 people included in the analysis, the mean6SD annual eGFR change was 20.5761.78 ml/min per 1.73 m 2 , and 287 (6.7%) participants presented rapid eGFR decline. Before adjustment for baseline eGFR, baseline 25-hydroxyvitamin D level was associated with both mean annual eGFR change and risk of rapid eGFR decline, independently of baseline albuminuria. Once adjusted for baseline eGFR, associations were no longer significant. For every 10 ng/ml higher baseline 25-hydroxyvitamin D, the adjusted mean annual eGFR change was 20.005 ml/min per 1.73 m 2 (95% confidence interval, 20.063 to 0.053; P=0.87) and the risk of rapid eGFR decline was null (odds ratio, 0.93; 95% confidence interval, 0.79 to 1.08; P=0.33). Baseline 25-hydroxyvitamin D level was not associated with incidence of CKD or albuminuria.Conclusions The association of 25-hydroxyvitamin D with eGFR decline is confounded by baseline eGFR. Sufficient 25-hydroxyvitamin D levels do not seem to protect from eGFR decline independently from baseline eGFR.

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“…The sampling procedure of the CoLaus Study has been described previously (Firmann et al, 2008). Briefly, the complete list of Lausanne inhabitants aged 35-75 years (n ¼ 56 694) was provided by the population registry of the city.…”

Section: Recruitmentmentioning

confidence: 99%

Metabolically healthy obesity: different prevalences using different criteria

Velho

Paccaud

Waeber³

et al. 2010

Eur J Clin Nutr

217

185

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Objective: To estimate the prevalence of metabolically healthy obesity (MHO) according to different definitions. Methods: Population-based sample of 2803 women and 2557 men participated in the study. Metabolic abnormalities were defined using six sets of criteria, which included different combinations of the following: waist; blood pressure; total, high-density lipoprotein or low-density lipoprotein-cholesterol; triglycerides; fasting glucose; homeostasis model assessment; high-sensitivity C-reactive protein; personal history of cardiovascular, respiratory or metabolic diseases. For each set, prevalence of MHO was assessed for body mass index (BMI); waist or percent body fat. Results: Among obese (BMI X30 kg/m 2 ) participants, prevalence of MHO ranged between 3.3 and 32.1% in men and between 11.4 and 43.3% in women according to the criteria used. Using abdominal obesity, prevalence of MHO ranged between 5.7 and 36.7% (men) and 12.2 and 57.5% (women). Using percent body fat led to a prevalence of MHO ranging between 6.4 and 43.1% (men) and 12.0 and 55.5% (women). MHO participants had a lower odd of presenting a family history of type 2 diabetes. After multivariate adjustment, the odds of presenting with MHO decreased with increasing age, whereas no relationship was found with gender, alcohol consumption or tobacco smoking using most sets of criteria. Physical activity was positively related, whereas increased waist was negatively related with BMI-defined MHO. Conclusion: MHO prevalence varies considerably according to the criteria used, underscoring the need for a standard definition of this metabolic entity. Physical activity increases the likelihood of presenting with MHO, and MHO is associated with a lower prevalence of family history of type 2 diabetes.

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The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome

Cited by 587 publications

References 32 publications

The association between inflammatory biomarkers and metabolically healthy obesity depends of the definition used

The association between inflammatory biomarkers and metabolically healthy obesity depends of the definition used

Serum 25-Hydroxyvitamin D Level and Kidney Function Decline in a Swiss General Adult Population

Metabolically healthy obesity: different prevalences using different criteria

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