The cognitive control network: Integrated cortical regions with dissociable functions

Cole, Michael W.; Schneider, Walter

doi:10.1016/j.neuroimage.2007.03.071

Cited by 951 publications

(798 citation statements)

References 44 publications

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“…Previous literature has established that during a variety of WM tasks ipsilateral frontoparietal cortical regions are functionally coupled (Esslinger et al, 2012;Cole and Schneider, 2007;Schlosser et al, 2006). The current study provides new evidence regarding the directionality of effective coupling within the verbal WM network.…”

Section: Discussionsupporting

confidence: 54%

Dynamic causal modeling of load-dependent modulation of effective connectivity within the verbal working memory network

2013

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This is the accepted version of the paper.This version of the publication may differ from the final published version. Permanent repository link AbstractNeuroimaging studies have consistently shown that working memory (WM) tasks engage a distributed neural network that primarily includes the dorsolateral prefrontal (DLPFC), the parietal (PAR) and the anterior cingulate cortices (ACC). The current challenge is to provide a mechanistic account of the changes observed in regional activity. To achieve this we characterised neuroplastic responses in effective connectivity between these regions at increasing WM loads using Dynamic Causal Modeling of functional magnetic resonance imaging data obtained from healthy individuals during a verbal n-back task. Our data demonstrate that increasing memory load was associated with (a) right-hemisphere dominance, (b) increasing forward (i.e. posterior to anterior) effective connectivity within the WM network, and (c) reduction in individual variability in WM network architecture resulting in the right-hemisphere forward model reaching an exceedance probability of 99% in the most demanding condition. Our results provide direct empirical support that task difficulty, in our case WM load, is a significant moderator of short-term plasticity, complementing existing theories of task-related reduction in variability in neural networks.

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Section: Discussionsupporting

confidence: 54%

Dynamic causal modeling of load-dependent modulation of effective connectivity within the verbal working memory network

2013

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“…We also found free-choice related activity in the DLPFC and the pre-SMA, but these regions did not show the conflict activation pattern we found in the RCZ, AI and the SG. The DLPFC and the pre-SMA are additional regions that have previously been associated with executive control (Cole & Schneider, 2007;Seeley et al, 2007;Demanet et al, 2013;Brass et al, 2013;Orr & Banich, 2014), but our findings suggest that they are not directly involved in overcoming conflict induced by unconscious primes. A study by Chambon et al (2012) using subliminal response priming did not find the DLPFC to be involved in conflict resolution either.…”

Section: Accepted Manuscriptcontrasting

confidence: 53%

Influences of unconscious priming on voluntary actions: Role of the rostral cingulate zone

et al. 2016

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The ability to make voluntary, free choices is fundamental to what it means to be human. A key brain region that is involved in free choices is the rostral cingulate zone (RCZ), which is part of the medial frontal cortex. Previous research has shown that activity in this brain region can be modulated by bottom-up information while making free choices. The current study extends those findings, and shows, for the first time, that activation in the RCZ can also be modulated by subliminal information. We used a subliminal response priming paradigm to bias free and cued choices. We observed more activation in the RCZ when participants made a choice that went against the prime's suggestion, compared to when they chose according to the prime. This shows that the RCZ plays an important role in overcoming externally-triggered conflict between different response options, even when the stimuli triggering this conflict are not consciously perceived. Our results suggest that an important mechanism of endogenous action in the RCZ may therefore involve exerting an internally-generated action choice against conflicting influences, such as external sensory evidence. We further found that subliminal information also modulated activity in the anterior insula and the supramarginal gyrus.

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“…This age-related attenuation of BOLD signal has been reported in other age-comparative studies on motor and cognitive brain activation (Hesselmann et al, 2001;Kannurpatti, Motes, Rypma, & Biswal, 2011). An opposite finding was that older adults exhibited larger brain activation than younger adults during task switching (Kunimi, Kiyama, & Nakai, 2016 (Cole & Schneider, 2007;Deprez et al, 2013). We did in particular expect increased prefrontal activation during dual tasking as observed by Holtzer et al (2011).…”

Section: Discussionmentioning

confidence: 66%

“…This network consists of a set of coactive fronto-parietal cortical regions (Cole & Schneider, 2007;Dosenbach et al, 2007;Niendam et al, 2012) that is, anterior cingulate cortex/presupplementary motor area, dorsolateral prefrontal cortex, inferior frontal junction, anterior insular cortex, dorsal premotor cortex, and posterior parietal cortex. Several studies found evidence that this network is also involved in cognitivemotor dual task paradigms (Rémy, Wenderoth, Lipkens, & Swinnen, 2010;Wu, Liu, Hallett, Zheng, & Chan, 2013).…”

Section: Introductionmentioning

confidence: 99%

Imaging gait analysis: An fMRI dual task study

et al. 2017

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The cognitive control network: Integrated cortical regions with dissociable functions

Cited by 951 publications

References 44 publications

Dynamic causal modeling of load-dependent modulation of effective connectivity within the verbal working memory network

Dynamic causal modeling of load-dependent modulation of effective connectivity within the verbal working memory network

Influences of unconscious priming on voluntary actions: Role of the rostral cingulate zone

Imaging gait analysis: An fMRI dual task study

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