“…1989 J. DE CAMPO, R. FOWLER The co-existence of VUR with P U J obstruction has generally been discounted as being mere coincidence (Lebowitz & Blickman 1983) but the tortuosity present at the PUJ in many children with moderate or severe vesico-ureteric reflux (and two of our cases) may provide the anatomical setting for PUJ obstruction to develop either intermittently or dJring a diuresis. In addition obstruction may be precipitated after the renal pelvis has been maximally distended by an episode of reflux.…”
Section: Valvular Kinking Of the Upper Ureter Which Cannotmentioning
The aetiology of pelivi-ureteric junction (PUJ) obstruction is controversial. We present four patients who had normal or equivocal intravenous pyelograms and non-obstructive Whitaker tests in whom complete pelvi-ureteric obstruction was precipitated by more rapid distension of the renal pelvis. We speculate that in vivo physiological urine flow rates and temporary kinking of PUJ produces a critical increase in pelvic volume and subsequent valvular kinking of the upper ureter, which cannot be usually achieved by maximal urine flow rates alone. Co-existence of vesico-ureteric reflux (VUR) may be a contributory factor to critical pelvic distension and tortuous PUJ. Volume related configurational changes of this type are probably a more frequent cause of PUJ obstruction than is generally recognised.
“…1989 J. DE CAMPO, R. FOWLER The co-existence of VUR with P U J obstruction has generally been discounted as being mere coincidence (Lebowitz & Blickman 1983) but the tortuosity present at the PUJ in many children with moderate or severe vesico-ureteric reflux (and two of our cases) may provide the anatomical setting for PUJ obstruction to develop either intermittently or dJring a diuresis. In addition obstruction may be precipitated after the renal pelvis has been maximally distended by an episode of reflux.…”
Section: Valvular Kinking Of the Upper Ureter Which Cannotmentioning
The aetiology of pelivi-ureteric junction (PUJ) obstruction is controversial. We present four patients who had normal or equivocal intravenous pyelograms and non-obstructive Whitaker tests in whom complete pelvi-ureteric obstruction was precipitated by more rapid distension of the renal pelvis. We speculate that in vivo physiological urine flow rates and temporary kinking of PUJ produces a critical increase in pelvic volume and subsequent valvular kinking of the upper ureter, which cannot be usually achieved by maximal urine flow rates alone. Co-existence of vesico-ureteric reflux (VUR) may be a contributory factor to critical pelvic distension and tortuous PUJ. Volume related configurational changes of this type are probably a more frequent cause of PUJ obstruction than is generally recognised.
“…The incidence of vesicoureteric reflux in patients with PUJ hydronephrosis varies between 10 and 20%. This clinical association of the two defects is well known but has not often been reported (Lebowitz and Blickman, 1983;Maizels et al, 1984). I t is important to differentiate between the two types of hydronephrosis associated with reflux, the first without evidence of obstruction on intravenous urography (reflux-induced hydronephrosis) and the second with obstruction at the pelviureteric junction.…”
Section: Additional Families With Puj Hydronephrosis Duplex Pelvicalmentioning
The incidence of pelviureteric junction (PUJ) hydronephrosis and a bifid pelvicaliceal collecting system was determined in the parents and siblings of 19 patients with PUJ hydronephrosis. The high incidence of hydronephrosis in first degree relatives supports the hypothesis that PUJ hydronephrosis is inherited by an autosomal dominant gene of variable penetrance. There is a genetic inter-relationship between PUJ hydronephrosis and a bifid pelvicaliceal system and therefore indirectly between vesico-ureteric reflux and paraureteric diverticula. Ultrasound screening of the children of adults with PUJ hydronephrosis may lead to earlier diagnosis and treatment, thus preventing renal damage.
“…In cases of secondary UPJO caused by VUR, initial pyeloplasty has been suggested to be a better initial management modality than the correction of VUR. 23 However, a recent report by Ebadi et al 24 demonstrated resolution of UPJO after endoureterotomy for distal UVJO. In our study, only 2 of 5 patients with initial UNC required additional pyeloplasty.…”
Section: Surgical Management and Outcomesmentioning
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