The Coexistence of Rheumatic Heart Disease and Sickle Cell Anemia: Review Of Literature and Report of Case

Plachta, Aaron; Speer, Francis D.

doi:10.1093/ajcp/22.10.970

Cited by 8 publications

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“…Although rheumatic heart disease has been stated to be a rare concomitant of sickle cell disease,' their occurrence together has been described.2 3 Sickle cell anemia as a cause of pulmonary vascular occlusion, pulmonary hypertension, and subsequent right ventricular hypertrophy is now well authenticated. 4 It has been suggested that sickle cell thrombi in the coronary vasculature occasionally result in coronary insufficiency.5 In view of the varied pathologic findings and the puzzling clinical picture presented by patients with sickle cell anemia, it was felt that hemodynamic studies in a group of such patients would be of interest.…”

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confidence: 99%

Hemodynamic Studies in Sickle Cell Anemia

et al. 1954

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Hemodynamic studies in 13 unselected patients with sickle cell anemia are reported. Twelve of these patients were also studied during mild exercise. The cardiac output at rest was elevated in all and rose significantly with exercise in 9 of the 12 patients. The importance of the increased percentage extraction of oxygen by the tissues in modifying the response of the cardiac output is discussed. The similarity of the response to exercise in the majority of these chronically anemic patients compared with the normal response is described. Included in this series is one case with secondary cor pulmonale and one case of concurrent rheumatic heart disease.

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Hemodynamic Studies in Sickle Cell Anemia

et al. 1954

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“…the association with rheumatic heart disease has been described. 4 Children with sickle cell anemia often have find¬ ings which cause suspicion of heart disease, but clinicians have grown to assume that murmurs, cardiomegaly, breathlessness, and abnormalities seen on x-ray films and ECGs are simply related to the anemia. As McKusick points out,5 physicians may be guilty of overlooking significant rheumatic (and now congenital) heart disease because of this as¬ sumption.…”

Section: Preoperative Electrocardiogrammentioning

confidence: 99%

Blalock-Taussig Shunt for Tetralogy of Fallot in a Patient With Sickle Cell Anemia

O'Keefe¹,

LePere²,

Britton³

1967

JAMA

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jaundice, thrombocytopenia, and mildly elevated hemoglobin level. However, it was interesting to speculate whether these findings were due to the hypermetabolic state per se or whether LATS may have had effects other than that of stimulating the thyroid gland.The presence of LATS in the mother might have been inferred from her physical examination find¬ ings. Recurrent hyperthyroidism, severe exophthal¬ mos, and pretibial myxedema have been associated with assay results which were positive for LATS.15 In fact, all patients with pretibial myxedema who have been studied had assay results which were positive for LATS. The presence of clubbing in the mother was of interest and raised the question of whether or not she had thyroid acropachy, which is another condition associated with elevated LATS.There was no evidence of soft tissue swelling or periosteal new bone formation in the hands, and whether clubbing alone is sufficient to make this diagnosis has not been established. Summary A patient with exophthalmos, pretibial myxe¬ dema, and thyrotoxicosis (which had recurred after a subtotal thyroidectomy) gave birth to a child with neonatal thyrotoxicosis. Both the mother and child had assay results which were positive for long-acting thyroid stimulator (LATS). In addi¬ tion to goiter and exophthalmos, the child had congestive heart failure, hepatosplenomegaly, jaun¬ dice, and thrombocytopenia. Histological examina¬ tion of the infant's thyroid gland at 3 months of age revealed hyperplasia with colloid vacuolation and papillary infolding of the follicles.

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Akuter fieberhafter Rheumatismus

Scherf

Boyd

1955

Klinik Und Therapie Der Herzkrankheiten Und Der Gefäßerkrankungen

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The Coexistence of Rheumatic Heart Disease and Sickle Cell Anemia: Review Of Literature and Report of Case

Cited by 8 publications

References 0 publications

Hemodynamic Studies in Sickle Cell Anemia

Hemodynamic Studies in Sickle Cell Anemia

Blalock-Taussig Shunt for Tetralogy of Fallot in a Patient With Sickle Cell Anemia

Akuter fieberhafter Rheumatismus

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