The codon 72 polymorphism of the TP53 gene and endometriosis risk: a meta-analysis

Feng, Yi; Wu, Yuanyuan; Li, Li; Luo, Zhiyong; Zhong, Lin; Zhou, Yinghui; Yi, Tao; Lin, Xiaojuan; Zhao, Qianying; Zhao, Xia

doi:10.1016/j.rbmo.2015.05.017

Cited by 5 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, a large number of genetic association studies showed that the genetic polymorphisms may have contributed to the development of endometriosis during the past 20 years. [8][9][10][11] However, conflicting results and the absence of replication in independent populations have led to the genetic contribution of endometriosis being questioned. 12 The failure of candidate gene studies is largely attributed to poor study design, insufficient power, and population differences.…”

Section: Introductionmentioning

confidence: 99%

Association of Endometriosis-Associated Genetic Polymorphisms From Genome-Wide Association Studies With Ovarian Endometriosis in a Chinese Population

Hao

Wang

et al. 2017

Reprod. Sci.

View full text Add to dashboard Cite

Endometriosis is a common multifactorial disease caused by an interaction between multiple gene loci and environment. Four genome-wide association studies (GWASs) of endometriosis have identified several single-nucleotide polymorphisms (SNPs) associated with endometriosis. However, results from independent replication studies with different populations are inconsistent. The present study aims to evaluate whether the GWAS-derived susceptibility loci are correlated with the risk of the development of ovarian endometriosis in North Chinese women. This case-control study comprised 580 patients with ovarian endometriosis and 606 matched control women. Three SNPs were selected for this association study including rs10965235 in CDKN2BAS, rs2235529 located in LINC00339- WNT4, and rs12700667 in an intergenic region on 7p15.2. The results show that the G/A genotype of rs12700667 can significantly increase the risk of developing ovarian endometriosis when compared with the G/G genotype (odds ratio [OR] = 1.57, 95% confidence interval [CI] = 1.23-2.00). Similarly, the carriers with A allele showed a higher risk of ovarian endometriosis than those with G allele (OR = 1.23, 95% CI = 1.12-1.68). The study suggests that the endometriosis-associated genetic polymorphisms (rs12700667) from GWAS be associated with the risk of developing ovarian endometriosis in North Chinese women.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of Endometriosis-Associated Genetic Polymorphisms From Genome-Wide Association Studies With Ovarian Endometriosis in a Chinese Population

Hao

Wang

et al. 2017

Reprod. Sci.

View full text Add to dashboard Cite

show abstract

“…Among them, somatic mutations of PIK3CA have been found to play an important role in the development of endometriosis into F I G U R E 7 Functionally grouped network (Red, green, blue, and pink represent clusters 1, 2, 3, and 4, respectively) endometriosis-associated ovarian cancer (Bulun et al, 2019). The 72 codon polymorphism of the TP53 gene is thought to be associated with the risk of endometriosis (Feng et al, 2015). Cluster analysis of the MCODE algorithm divides the PPI network into four sub-networks, which extracts some noteworthy targets.…”

Section: Discussionmentioning

confidence: 99%

Analysis of astaxanthin molecular targets based on network pharmacological strategies

Lin

Tan

et al. 2021

J Food Biochem

View full text Add to dashboard Cite

In order to further explore the potential pharmacological activity of astaxanthin (AST), network pharmacological approaches were employed in this work to systematically investigate its affinity targets, perturbed signaling pathways, and related disease applications. First, potential targets were captured based on AST chemical structure information. Enrichment analysis was then performed using bioinformatics tools to predict the biological processes and diseases in which AST targets are involved. The results suggest that AST is involved in steroid hormone metabolism, and the regulation of glucocorticoids may be one of the potential mechanisms of its known therapeutic effects on depression and insulin resistance. Molecular docking experiments confirmed that AST can form stable binding to several key nodes (SRD5A2, STS, AKR1C2, HSD11B1, and CYP17A1) in steroid hormone biosynthesis.More importantly, the molecular targets of AST were the most significantly associated with endometriosis. Functionally, grouped analysis of key therapeutic nodes was carried out by establishing the interaction network between drug targets and disease targets. While exerting inflammatory effects, the regulation of estrogen and other semiochemicals by targeting steroid metabolism may be the biological basis for the potential treatment of endometriosis with AST. This work provides a theoretical basis for further exploring the pharmacological mechanisms of AST and development of new therapeutic applications. Practical applicationsIn this study, systematic pharmacological methods were used to identify the potential therapeutic effects and associated mechanisms of astaxanthin, providing a bioinformatics basis for further exploration of astaxanthin's new pharmacological properties in foods.

show abstract

“…It is known that the expression of p53 in endometriotic tissues is lower than that in the eutopic endometrium of endometriosis or normal endometrium [36]. In addition, the p53 codon 72 gene polymorphism is associated with endometriosis susceptibility, especially in Latin American and Asian populations [37].…”

Section: Discussionmentioning

confidence: 99%

Overexpressed MPS-1 contributes to endometrioma development through the NF-κB signaling pathway

Liu

Zhang

et al. 2021

Reprod Biol Endocrinol

View full text Add to dashboard Cite

Background Endometriosis is a benign gynecological disease that shares some characteristics with malignant tumors and affects approximately 10% of women of reproductive age. Endometrioma refers to endometriosis that appears in the ovary. Metallopanstimulin-1 (MPS-1) is a component of the 40S subunit of ribosomes that has extra-ribosomal functions that contribute to the development of diseases. This study aimed to explore the expression pattern and role of MPS-1 in endometrioma development. Methods Quantitative real time polymerase chain reaction, western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay were used to determine the expression of MPS-1 in patients with endometrioma. Following the successful knockdown of MPS-1 by siRNA, CCK-8 assays, flow cytometry, and transwell assays were performed to detect ectopic endometrial stromal cells (EcESCs) proliferation, the rate of apoptosis, and cell cycle, migration, and invasion, respectively. Western blotting was used to explore the effect of MPS-1 knockdown on protein levels in the NF-κB signaling pathway. Results The expression of MPS-1 was significantly higher in endometrioma and the serum of endometrioma patients than in the patients without endometriosis. In addition, the downregulation of MPS-1 expression inhibited EcESCs proliferation, migration, and invasion. This downregulation led to the arrest of the EcESCs cycle in the G0/G1 phase and apoptosis and depressed the NF-κB signaling pathway. Conclusion MPS-1 can regulate EcESCs proliferation, motility, invasion, apoptosis, and cell cycle via the NF-κB signaling pathway in endometrioma. This may contribute to the formation or development of endometriotic foci. This study suggests the potential role of MPS-1 in the pathogenesis of endometriosis and enabled further research into the use of MPS-1 in the clinical diagnosis of endometrioma.

show abstract

The codon 72 polymorphism of the TP53 gene and endometriosis risk: a meta-analysis

Cited by 5 publications

References 45 publications

Association of Endometriosis-Associated Genetic Polymorphisms From Genome-Wide Association Studies With Ovarian Endometriosis in a Chinese Population

Association of Endometriosis-Associated Genetic Polymorphisms From Genome-Wide Association Studies With Ovarian Endometriosis in a Chinese Population

Analysis of astaxanthin molecular targets based on network pharmacological strategies

Overexpressed MPS-1 contributes to endometrioma development through the NF-κB signaling pathway

Contact Info

Product

Resources

About