The coagulation system in host defense

Antoniak, Silvio

doi:10.1002/rth2.12109

Cited by 153 publications

(126 citation statements)

References 97 publications

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“…Disseminated intravascular coagulopathy (DIC) and similar coagulopathic phenotypes are promoted in infection 15 , and also in heat stroke 16 . The two coagulopathy-promoting stimuli experienced together, or in short succession, may produce a synergistic effect, as we observed in this work.…”

Section: Discussionmentioning

confidence: 99%

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model

Proctor

Dineen

Nostrand

et al. 2019

Preprint

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Text word count: 3,988; Abstract word count: 250; Number of figures: 5; Number of tables: 0; Number of references: 32 Scientific category: Thrombosis and HemostasisKey points:• A signature of pro-coagulation markers predicts circadian core body temperature and levels of organ damage in heat stroke • Changes in coagulopathy-related gene expression are evidenced before histopathological organ damage AbstractHeat stroke is a life-threatening condition characterized by loss of thermoregulation and severe elevation of core body temperature, which can cause organ failure and damage to the central nervous system. While no definitive test exists to measure heat stroke severity, immune challenge is known to increase heat stroke risk, although the mechanism of this increased risk is unclear. In this study, we used a mouse model of classic heat stroke to test the effect of immune challenge on pathology. Employing multivariate supervised machine learning to identify patterns of molecular and cellular markers associated with heat stroke, we found that prior viral infection simulated with poly I:C injection resulted in heat stroke presenting with high levels of factors indicating coagulopathy. Despite a decreased number of platelets in the blood, platelets are large and non-uniform in size, suggesting younger, more active platelets. Levels of D-dimer and soluble thrombomodulin were increased in more severe heat stroke, and in cases presenting with the highest level of organ damage markers D-dimer levels dropped, indicating potential fibrinolysisresistant thrombosis. Genes corresponding to immune response, coagulation, hypoxia, and vessel repair were up-regulated in kidneys of heat-challenged animals, and these increases correlated with both viral treatment and distal organ damage while appearing before discernible tissue damage to the kidney itself. We conclude that heat stroke-induced coagulopathy may be a driving mechanistic force in heat stroke pathology, especially when exacerbated by prior infection, and that coagulation markers may serve as an accessible biomarker for heat stroke severity and therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model

Proctor

Dineen

Nostrand

et al. 2019

Preprint

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“…The coagulation system can be activated by a variety of different viruses, including HIV, Dengue virus, and Ebola virus (21,22). During the relatively recent outbreak of SARS-CoV in 2003, which was associated with even higher morbidity and mortality than COVID-19, vascular endothelial damage in both small-and mid-sized pulmonary vessels was noted together with DIC, DVT and PE resulting in pulmonary infarction (23)(24)(25)(26).…”

Section: Coagulation and Covid-19mentioning

confidence: 99%

Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands

Oudkerk¹,

Büller²,

Kuijpers³

et al. 2020

Radiology

327

332

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A potential link between mortality, D-dimer values and a prothrombotic syndrome has been reported in patients with COVID-19 infection. The National Institute for Public Health of the Netherlands asked a group of Radiology and Vascular Medicine experts to provide guidance for the imaging workup and treatment of these important complications. This report summarizes evidence for thromboembolic disease, potential diagnostic and preventive actions as well as recommendations for patients with COVID-19 infection.

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“…Thrombin is synthesized in the liver and plays a central role in blood coagulation. In addition, it is now considered that coagulation components, including thrombin, are closely associated with the immune system and are essential for effective immune responses to control infection (Antoniak et al, 2018). In fact, inhibition of thrombin, the major blood coagulation factor used in this study, increases the risk and severity of viral infection (Antoniak et al, 2013).…”

Section: Results and Discussion:-mentioning

confidence: 96%

Thrombin Enhances Ovalbumin-Specific Iga in Mucosal Surfaces by Intranasal Administration in Mice.

Kaminaka¹,

Nozaki.²

2019

IJAR

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The coagulation system in host defense

Cited by 153 publications

References 97 publications

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model

Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands

Thrombin Enhances Ovalbumin-Specific Iga in Mucosal Surfaces by Intranasal Administration in Mice.

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