1998
DOI: 10.1093/emboj/17.2.507
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The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways

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Cited by 468 publications
(483 citation statements)
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“…In animals, this short L**LL motif exists in a large variety of nuclear proteins functioning as transcriptional coactivators, such as SRC-1/p160, TIF-2/GRIP-1, CBP/p300, and RIP-140. The animal L**LL motif mediates binding to liganded nuclear receptors and other transcription factors, such as the cAMP response element-binding (CREB) protein, which is one of the best characterized bZIP proteins in animals (Ribeiro et al, 1994;Le Douarin et al, 1996;Heery et al, 1997;Voegel et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
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“…In animals, this short L**LL motif exists in a large variety of nuclear proteins functioning as transcriptional coactivators, such as SRC-1/p160, TIF-2/GRIP-1, CBP/p300, and RIP-140. The animal L**LL motif mediates binding to liganded nuclear receptors and other transcription factors, such as the cAMP response element-binding (CREB) protein, which is one of the best characterized bZIP proteins in animals (Ribeiro et al, 1994;Le Douarin et al, 1996;Heery et al, 1997;Voegel et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…2A). This peptide resembles the a-helical L**LL motif known to mediate the interaction between transcriptional coactivators and liganded nuclear receptors as well as many other transcription factors in animals through a hydrophobic face formed by its Leu residues (Le Douarin et al, 1996;Heery et al, 1997;Voegel et al, 1998). To test by yeast twohybrid interaction screens whether this a-helical L**LL motif of ROXY1 is essential for binding to plant TGA transcription factors, five mutagenized ROXY1 proteins were engineered by replacing one, two, or all three strongly hydrophobic Leu residues located in this motif by an Ala, which possesses a shorter and thus only weakly hydrophobic side chain ( Fig.…”
Section: Analysis Of the Roxy1 C-terminal L**ll Motifmentioning
confidence: 99%
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“…Taken together, these results suggested that p68 acts as a hERa AF-1 speci®c coactivator to constitute the cross-talk with growth factor signalling. During a detailed analysis of p68 as a hERa AF-1 coactivator, we isolated a common interactant ( two intrinsic transactivation domains (AD1 and AD2) (Kalkhoven et al 1998;Voegel et al 1998). Direct binding and potentiation by p300/CBP were reported in AD1, while a coactivator associating with AD2 remained unknown.…”
Section: Molecular Mechanism Of the Novel Cross-talk Between Oestrogementioning
confidence: 99%
“…These proteins are grouped into three subclasses based on their sequence homology; i.e., SRC-1/NCoA-1 (Hong et al, 1997;Torchia et al, 1997;Voegel et al, 1998), TIF2/GRIP1/NCoA-2 (Hong et al, 1997;Voegel et al, 1998), and p/CIP/ ACTR/AIB1/xSRC-3 (Anzick et al, 1997;Chen et al, 1997;Kim et al, 1998;Torchia et al, 1997). A distinctive structural feature of the p160 coactivators is the presence of multiple LXXLL signature motifs (Heery et al, 1997;Torchia et al, 1997).…”
Section: The P160 Familymentioning
confidence: 99%