The CNS midline cells and Egfr signaling genes are required for establishment of the RP2 motoneuron lineage in the Drosophila central nervous system

Huh, Jung Yun; Jeon, Sang-Hak; Kim, Sang Hee

doi:10.1016/j.bbrc.2009.01.104

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Drosophila Cns Midline Cells and The Function Of Midline Glia1

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2010

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“…of lateral CNS neurons. 3,4 The details of midline-directed axon guidance have been expertly reviewed, 7,8 and here, only select cellular and molecular mechanisms that mediate aspects of MG to neuron signaling are considered.…”

Section: Future Directionsmentioning

confidence: 99%

“…They carry-out a variety of important developmental and neuronal support roles. These include trophic support of commissural axons, 2 cell signaling pathways that influence the formation and migration of nearby cell types, [3][4][5][6] and production of Netrins and Slit that influence axon guidance. 7,8 Most evident is their role in ensheathing the commissural axons that cross the CNS midline ( Fig.…”

Section: Drosophila Cns Midline Cells and The Function Of Midline Gliamentioning

confidence: 99%

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Axon–glial interactions at the Drosophila CNS midline

Crews¹

2010

Cell Adhesion & Migration

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The glia that reside at the midline of the Drosophila CNS are an important embryonic signaling center and also wrap the axons that cross the CNS. The development of the midline glia (MG) is characterized by migration, ensheathment, subdivision of axon commissures, apoptosis, and the extension of glial processes. All of these events are characterized by cell-cell contact between MG and adjacent neurons. Cell adhesion and signaling proteins that mediate different aspects of MG development and MG-neuron interactions have been identified. This provides a foundation for ultimately obtaining an integrated picture of how the MG assemble into a characteristic axonal support structure in the CNS.

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Section: Future Directionsmentioning

confidence: 99%