The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma

Shin, Eun Hee; Ryu, Han Suk; Kim, Soohee; Jung, Haeyoen; Jang, Ja‐June; Lee, Kyuho

doi:10.1007/s00534-010-0367-0

Cited by 30 publications

(28 citation statements)

References 21 publications

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“…HCCs express Afp and Gpc3 mRNA (16,17), and immunostain positively for GST-P and HSP-70 of HCC (18,19). These observations support the hypothesis that the liver tumors observed in STAM-F mice were HCCs.…”

Section: Discussionsupporting

confidence: 74%

Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis

et al. 2015

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Abstract. The molecular mechanisms underlying the progression of nonalcoholic steatohepatitis (NASH) have not been fully elucidated. The aim of this study was to identify factors involved in NASH progression by analysis of pathophysiological features and gene-expression profiles in livers of STAM mice, a model of NASH-associated hepatocarcinogenesis. C57BL/6N (B6N) mice were injected with streptozotocin to generate STAM mice. Four-week-old male STAM and B6N

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Section: Discussionsupporting

confidence: 74%

Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis

et al. 2015

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“…In addition, HSP70 was specifically upregulated in human HCCs (Fig. 1E), which is in agreement with previous reports implicating HSP70 as a marker for HCC development (37,38). Another notable effect of hsp70 deletion was the inhibitory effect on tumor angiogenesis, which was verified by CD31 staining (Fig.…”

supporting

confidence: 91%

The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways

Cho

Jin

Pang

et al. 2019

Molecular and Cellular Biology

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Delineating the mechanisms that drive hepatic injury and hepatocellular carcinoma (HCC) progression is critical for development of novel treatments for recurrent and advanced HCC but also for the development of diagnostic and preventive strategies. Heat shock protein 70 (HSP70) acts in concert with several cochaperones and nucleotide exchange factors and plays an essential role in protein quality control that increases survival by protecting cells against environmental stressors. Specifically, the HSP70-mediated response has been implicated in the pathogenesis of cancer, but the specific mechanisms by which HSP70 may support malignant cell transformation remains to be fully elucidated. Here, we show that genetic ablation of HSP70 markedly impairs HCC initiation and progression by distinct but overlapping pathways. This includes the potentiation of the carcinogen-induced DNA damage response, at the tumor initiation stage, to increase the p53-dependent surveillance response leading to the cell cycle exit or death of genomically damaged differentiated pericentral hepatocytes, and this may also prevent their conversion into more proliferating HCC progenitor cells. Subsequently, activation of a mitogenactivated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) negative feedback pathway diminishes oncogenic signals, thereby attenuating premalignant cell transformation and tumor progression. Modulation of HSP70 function may be a strategy for interfering with oncogenic signals driving liver cell transformation and tumor progression, thus providing an opportunity for human cancer control.

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“…Its expression was observed in 282 of 392 HCC cases (71.9%), whereas only 14 of 115 non-neoplastic liver tissues expressed HSP70 (P<0.001) (9). The sensitivity and specificity in detecting HCC were identified as 57.5 and 85%, respectively (10).…”

Section: Proteantigenmentioning

confidence: 99%

Tumor markers for hepatocellular carcinoma

Zhao¹,

Ju²,

Li³

2013

Molecular and Clinical Oncology

221

180

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a high rate of morbidity and mortality. HCC affects approximately one million individuals annually worldwide, with the incidence equal to the mortality rate. In 2008, HCC was listed as the third most lethal cancer. Thus, early diagnosis is crucial for improving the survival rate for patients. α-fetoprotein (AFP) together with iconography and pathology detection are commonly used in the clinical early diagnosis of liver cancer. However, the specificity and sensitivity of AFP used in screening for liver cancer are not satisfactory. Athough the development of molecular biology has led to the identification of new tumor markers, including proteantigens, cytokines, enzymes and isoenzymes, as well as related genes that can be used in the treatment and prognosis of liver cancer, more tumor markers are required for effective early diagnosis of diseases and monitoring of the curative effect.

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The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma

Abstract: The findings of the present study suggest that HSP70 be viewed as a predictor of prognosis as well as a useful diagnostic marker for HCC.

Cited by 30 publications

References 21 publications

Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis

Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis

The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways

Tumor markers for hepatocellular carcinoma

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