The Clinicopathological Differences of Colon Cancer in Young Adults Versus Older Adults

Leopa, Nicoleta; Dumitru, Eugen; Dumitru, Andrei; Tecchio, Cristina; Prazaru, Marius Dragos; Costea, Daniel Ovidiu; Popescu, R.

doi:10.1089/jayao.2021.0184

Cited by 7 publications

(23 citation statements)

References 24 publications

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“…The staff at our clinic continues to improve the healthcare provided to HIV-infected patients, especially the women of childbearing age, to allow them the chance to have a healthy child [ 13 , 14 , 15 , 16 , 17 , 18 ]. Our study shows that there were no differences in the sex of the newborns between the Constanta and Craiova RCs, with more than 50% being boys.…”

Section: Discussionmentioning

confidence: 99%

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

et al. 2023

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Background and Objectives: The present study assessed the fetal growth restriction and clinical parameters of both human immunodeficiency virus (HIV)-negative and HIV-positive newborns from HIV-infected mothers in two HIV-acquired immunodeficiency syndrome regional centers (RCs) in Constanta and Craiova, Romania, in order to evaluate the adverse birth-related outcomes. Materials and Methods: These represent a retrospective study conducted between 2008 and 2019, in which 408 pregnant HIV-positive women, 244 from Constanta RC and 164 from Craiova RC, were eligible to participate in the study. Consecutive singleton pregnancies delivered beyond 24 weeks of pregnancy were included. Growth restriction in newborns was defined as the birth weight (BW) being less than the third percentile, or three out of the following: BW < 10th percentile; head circumference (HC) < 10th percentile; birth length (BL) < 10th percentile; prenatal diagnosis of fetal growth restriction; and maternal pregnancy information. Of the 244 newborns delivered in Constanta, RC, 17 were HIV-positive, while in Craiova, RC, of the 164 newborns, 9 were HIV-positive. All HIV-positive women were on combined antiretroviral therapy (cART) during pregnancy, similar to all HIV-positive newborns who received ARTs for the first six weeks. We search for the influence of anthropometrical parameters (i.e., HC, BL, and BW), as well as clinical parameters (i.e., newborn sex and Apgar score) for both HIV-negative and HIV-positive newborns, along with the survival rate of HIV-positive newborns. Results: There were no differences in the sex of the newborns within either group, with more than 50% being boys. Similarly, the Apgar score did not show any statistically significant values between the two groups (i.e., p = 0.544 for HIV-positive newborns vs. p = 0.108 for HIV-negative newborns). Interestingly, our results showed that in Craiova, RC, there was a chance of 2.16 to find an HIV-negative newborn with an HC < 10th percentile and a 2.54 chance to find an HIV-negative newborn with a BL < 10th percentile compared to Constanta, RC, without any significant differences. On the contrary, Constanta, RC, represented a higher risk of death (i.e., 3.049 times, p = 0.0470) for HIV-positive newborns compared to Craiova, RC. Conclusions: Our results support the idea that follow-up of fetal growth restriction should be part of postnatal care in this high-risk population to improve adverse birth-related outcomes.

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Section: Discussionmentioning

confidence: 99%

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

et al. 2023

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“…In 2017, 451 million people were diagnosed with diabetes worldwide and the prevalence in the next 25 years is expected to increase by >200 million new cases (2). Type II DM (T2DM) accounts for approximately 90 to 95% of all diagnosed cases of diabetes and has a similar global trend to that of total diabetes (3), with developing countries exhibiting an increase in the number of newly diagnosed cases (4,5).…”

Section: Introductionmentioning

confidence: 99%

Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery

et al. 2022

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Diabetes mellitus (DM) promotes colorectal cancer (CRC) carcinogenesis through complex processes and is considered as an independent risk factor for cancer in general and for CRC in particular. Diabetic patients have complications in the postoperative period following CRC surgery. The aim of the present study was to explore the effect of type II DM (T2DM) on postoperative outcomes for CRC compared with non-diabetic patients. The present study analyzed the data from patients admitted to the General Surgery Department, Emergency Hospital of Constanța (Romania) diagnosed with CRC and DM compared with a control group (patients with CRC, without DM, recruited in the same period and frequency matched to cases by number, sex and age) analyzing patient comorbidities and postoperative complications. A total of 61 patients had undergone surgery for CRC and met the inclusion criteria in the present study conducted during September 2020-2021. A total of 30 patients associated T2DM. Diabetic patients have been associated with more comorbidities than non-diabetics; the age-adjusted Charlson comorbidity index score ≥6 was identified in 90% of diabetic patients compared with 45.2% of controls. Grade III Clavien-Dindo classification was observed in 13.3% diabetic patients compared with 3.2% of non-diabetic patients. Additionally, a higher rate of urinary and pulmonary complications (6.7 vs. 3.2% in controls respectively) in patients with diabetes was found. Postoperative hospitalization was prolonged in diabetic patients (P=0.042). Univariate and multivariate analyses revealed that the laparoscopic approach for diabetic patients was found to be associated with

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“…Candida vulvovaginitis is characterized by the appearance of inflammatory changes in the vaginal and vulvar epithelium secondary to infection with Candida species [ 1 , 2 ]. Candida albicans species (very common, in over 90% of cases) or non-albicans Candida (NAC) species, such as C. glabrata, C. tropicalis, C. krusei, and C. parapsilosis (10% of cases) are part of the normal vaginal flora in many women and are a type of fungi that present themselves like eukaryotic organisms found in the form of yeasts, molds or dimorphic fungi [ 2 , 3 , 4 ]. These microorganisms can become pathogenic especially when favorable conditions occur [ 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Candida albicans species (very common, in over 90% of cases) or non-albicans Candida (NAC) species, such as C. glabrata, C. tropicalis, C. krusei, and C. parapsilosis (10% of cases) are part of the normal vaginal flora in many women and are a type of fungi that present themselves like eukaryotic organisms found in the form of yeasts, molds or dimorphic fungi [ 2 , 3 , 4 ]. These microorganisms can become pathogenic especially when favorable conditions occur [ 3 , 5 ]. The risk factors incriminated in favoring the appearance of this type of infection are represented by the administration of certain drugs (hormonal treatments, oral contraceptives, antibiotics, corticotherapy), physiological or pathological conditions characterized by hyperestrogenism (pregnancy, obesity), various conditions such as diabetes, conditions of immunosuppression [oncological patients undergoing chemotherapy, patients diagnosed with human immunodeficiency virus (HIV) infection or patients undergoing a transplant], unprotected sexual contact, poor hygiene conditions, etc.…”

Section: Introductionmentioning

confidence: 99%

“…The risk factors incriminated in favoring the appearance of this type of infection are represented by the administration of certain drugs (hormonal treatments, oral contraceptives, antibiotics, corticotherapy), physiological or pathological conditions characterized by hyperestrogenism (pregnancy, obesity), various conditions such as diabetes, conditions of immunosuppression [oncological patients undergoing chemotherapy, patients diagnosed with human immunodeficiency virus (HIV) infection or patients undergoing a transplant], unprotected sexual contact, poor hygiene conditions, etc. [ 1 , 3 , 4 , 6 ]. Vaginal Candida infection occurs when these species of fungi superficially penetrate the mucosa of the vagina, thus causing a local inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and morphopathological assay in vulvovaginal candidiasis

Manolea

Istrate-Ofiţeru²,

Săndulescu³

et al. 2022

Rom J Morphol Embryol

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Candida vulvovaginitis is characterized by the appearance of inflammatory changes in the vaginal and vulvar epithelium secondary to infection with Candida species. The purpose of this study was to analyze and compare the clinical, microbiological, and histopathological aspects of pregnant and non-pregnant patients, symptomatic or asymptomatic in the case of candida vaginitis and to correlate the microscopic aspects with the symptoms before applying the local treatment with Nystatin. The study presents a retrospective analysis of the management of vaginitis in 166 pregnant or non-pregnant patients during 2021–2022. We observed the structure of the Malpighian squamous epithelium without keratinization present on the vaginal mucosa and the structure of the subepithelial connective tissue, which shows increased numerical values of inflammatory and vascular cellularity in the case of candida vaginitis symptomatic compared to asymptomatic ones. We noticed also in the microscopic study that in cases of asymptomatic patients before treatment, the number of inflammatory cells and blood vessels situated immediately under the epithelium was significantly lower compared to their number in symptomatic patients before treatment. Analyzing the results obtained after the administration of the treatment proposed by us, we can say that local Nystatin treatment is beneficial and safe for pregnant and non-pregnant patients and is a good alternative for patients with recurrent vulvovaginal candidiasis.

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The Clinicopathological Differences of Colon Cancer in Young Adults Versus Older Adults

Cited by 7 publications

References 24 publications

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery

Clinical and morphopathological assay in vulvovaginal candidiasis

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