The Clinicopathological correlation in suspected cases of chronic liver disease with the aid of liver biopsy - A study in tertiary health centre

Verma, Abhishek; Sinha, Somya; Panicker, N K

doi:10.5455/ijmsph.2016.25072016550

Cited by 2 publications

(6 citation statements)

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“…Liver biopsy done in these patients yielded a diagnosis in all cases. These findings were consistent with similar studies done by Chawla et al [1] where 74% of cases complained of abdominal pain with discomfort while 42% had hepatomegaly clinically. In another series [9] , 10% patients had abdominal pain while 48% patients had hepatomegaly.…”

Section: Discussionsupporting

confidence: 93%

“…The world health statistics 2007-2009 indicate that chronic liver disease occurs in age group of more than 55 years with steady increase in death rate up to 75+ years. [1,5] In this study, majority of the individuals suffering from chronic liver disease were in 40-60 years of age with male preponderance. Similar results of male predominance is Annals of Pathology and Laboratory Medicine, Vol.…”

Section: Discussionmentioning

confidence: 64%

“…6, Issue 9, September, 2019 reported in other studies. [1,5,6,7] The cause for this is most probably due to alcohol intake which is highest among middle aged males all over the world. However, in a study by Drebber et al [8] , it was found that females were affected more than males.…”

Section: Discussionmentioning

confidence: 99%

“…Perisinusoidal fibrosis was noted. Biopsy performed by Verma et al [1] found 27% cases had NASH diagnosed on liver biopsy while Laurin [8] found 2-3% cases of NASH on liver biopsy after excluding viral, metabolic, autoimmune, and genetic causes of chronic liver disease.…”

Section: Discussionmentioning

confidence: 99%

“…It gives us important information regarding parenchymal integrity, degree of fibrosis, bile duct status and deposition of materials in the liver. [1,2,3] Liver biopsy is an important investigation and plays a valuable role in diagnosis, prognostic and management of liver diseases. The main indications are in the diagnosis and staging of parenchymal liver diseases, abnormal liver function tests of unknown aetiology, fever of unknown origin, focal or diffuse abnormalities on imaging studies and also in developing treatment plans based on histologic analysis.…”

Section: Introductionmentioning

confidence: 99%

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Changing Role of Liver Biopsy Indications in A Tertiary Care Centre

Kalaranjini

Glaxon

Vasudevan

2019

APALM

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Background:The histomorphological study of liver biopsy is the best means to ascertain the nature and signifi¬cance of pathological processes occurring in the liver. The current non-invasive tools are unqualified to replace liver biopsy in clinical practice.Methods: This is a one year prospective study from January 2017 to 2018. A total of twenty five cases suspected to have chronic parenchymal liver disease, inflammatory lesions or neoplastic lesions were included in the study. Detailed history and investigations done including biochemical parameters, radiological and other investigative procedures done were recorded and percutaneous liver biopsy was done using trucut needle.Results: Out of the total 25 liver biopsy done, 60% cases were male, 40% were females. Majority of the patients belonged to the sixth decade (32%). Youngest patient was a 12 year boy with history of intermittent jaundice since birth, and the oldest patient was a 78 year old male. The most prevalent pathological diagnosis was cirrhosis with steatohepatitis with 7 cases (28%), followed by Non Alcoholic Fatty Liver Disease (NAFLD) and autoimmune hepatitis, 12% each. Conclusion:Liver biopsy is the gold standard for diagnosis of chronic liver diseases and plays a valuable role in diagnosis, prognostic and management of liver diseases.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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