The Clinical Value of Postoperative Transarterial Chemoembolization for Resectable Patients with Intermediate Hepatocellular Carcinoma After Radical Hepatectomy: a Propensity Score-Matching Study

Wang, Lei; Lin, Nanping; Lin, Kongying; Xiao, Chunhong; Ren, Wei; Zhou, Weiping; Liu, Jingfeng

doi:10.1007/s11605-020-04588-5

Cited by 8 publications

(6 citation statements)

References 56 publications

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“…As shown in the subgroup analysis, HCC patients with BDTT could gain more survival benefits from liver resection than TACE if the tumor number is single. Tumor number reflects the tumor burden of the BDTT patients, and more tumor lesions mean insufficient normal liver volume, which poses challenges for operation and increases the risk of postoperative liver failure ( 33 ). According to the clonal origin theory of HCC, early recurrence is often associated with single center occurrence because of residual tumor seeds and early vascular invasion ( 34 ), whereas late recurrence is usually related to multiple center recurrence and liver cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis

et al. 2022

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BackgroundHepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is rare. The aim of this study is to evaluate the long-term prognosis of liver resection (LR) versus transcatheter arterial chemoembolization (TACE) in these patients.MethodsData from HCC patients with BDTT who underwent liver resection and TACE were analyzed respectively. Propensity score matching (PSM) analysis was performed in these patients.ResultsA total of 145 HCC patients with BDTT were divided into two groups: the LR group (n = 105) and the TACE group (n = 40). The median OS in the LR group was 8.0 months longer than that in the TACE group before PSM (21.0 vs. 13.0 months, P <0.001) and 9.0 months longer after PSM (20.0 vs. 11.0 months, P <0.001). The median DFS in the LR group was 3.5 months longer than that in the TACE group before PSM (7.0 vs. 3.5 months, P = 0.007) and 5 months longer after PSM (7.0 vs. 2.0 months, P = 0.007).ConclusionIf surgery is technically feasible, liver resection provides better prognosis for HCC patients with BDTT compared with TACE.

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Section: Discussionmentioning

confidence: 99%

Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis

et al. 2022

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“…Data from patients diagnosed with NBNC-HCC who underwent hepatectomy as a primary anti-cancer therapy between April 28, 2008 and December 30, 2015 were extracted from the primary liver cancer big data (PLCBD) ( 21 , 22 ). In this study, patients with HCC who were seronegative for hepatitis B surface antigen, HBV- deoxyribonucleic acid (DNA), hepatitis C antibody, and HCV-RNA test were considered patients with NBNC-HCC ( 23 ).…”

Section: Methodsmentioning

confidence: 99%

“…Host inflammatory response to cancer and tumor-mediated systemic inflammation promote migration, invasion, and metastasis of malignant cells ( 10 , 11 ); they are prognostic factors for HCC ( 12 ). Recent studies have demonstrated that preoperative inflammatory indices, such as the neutrophil-to-lymphocyte ratio (NLR) ( 13 ), neutrophil times γ-glutamyl transpeptidase-to-lymphocyte ratio (NγLR) ( 14 ), platelet-to-lymphocyte ratio (PLR) ( 15 ), prognostic nutritional index (PNI) ( 16 ), aspartate aminotransferase-to-neutrophil ratio (ANRI) ( 17 ), γ-glutamyl transpeptidase-to-platelet ratio (GPR) ( 18 ), aspartate aminotransferase-to-lymphocyte ratio index (ALRI) ( 19 ) and platelet times neutrophil-to-lymphocyte ratio (PNLR) ( 20 ) are independent prognostic factors for patients with HCC who have undergone liver resection and have been used in the construction of several prognosis prediction models; however, the relationship between these inflammatory indexes and prognosis of NBNC-HCC, and the inflammatory index with the highest prognostic significance remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Pre- and Postoperative Models for Prediction of Recurrence in Non-B, Non-C Hepatocellular Carcinoma

et al. 2021

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Background and AimsThe incidence of non-B, non-C hepatocellular carcinoma (NBNC-HCC) is increasing. Like in hepatitis B virus (HBC)/HCV-associated HCC, treatment of NBNC-HCC after resection is challenging due to its high recurrence rate. However, few studies on the recurrence of NBNC-HCC have been published in the past decades. Hence, we aimed to investigate the risk factors for recurrence of NBNC-HCC and construct pre- and postoperative prognostic models for predicting recurrence in these patients who underwent curative resection.MethodsWe retrospectively analyzed 608 patients who underwent liver resection for NBNC-HCC. A multivariate Cox proportional hazard regression analysis was conducted to identify the independent risk factors of recurrence, based on which the prediction nomogram models were constructed and validated. The predictive performance of the models was assessed using the concordance index, time-dependent receiver operating characteristic curve, prediction error cure, and calibration curve. To facilitate clinical use, we stratified the patients into three distinct risk groups based on the score of the models. The cutoff scores of the models were determined by a survival tree analysis.ResultsMultivariable analysis identified neutrophil-to-lymphocyte ratio, alpha fetoprotein, tumor number, and tumor diameter as independent preoperative risk factors for recurrence. In addition to these variables, microvascular invasion was an independent postoperative risk factor for recurrence. The pre- and postoperative nomograms were constructed based on these variables. The C-index of the pre- and postoperative nomograms was 0.689 and 0.702 in the training cohort, 0.682 and 0.688 in the validation cohort, respectively, which were both higher than those of the conventional Barcelona Clinic Liver Cancer (BCLC) and 8th edition of the American Joint Committee on Cancer (AJCC8th) staging systems. In addition, the pre- and postoperative nomograms could also re-stratify patients with BCLC stage 0/A or AJCC8th stage IA/IB/II into distinct risk groups.ConclusionsWe constructed pre- and postoperative prognostic models for predicting recurrence in patients with NBNC-HCC who underwent curative resection. They can play a supplementary role to the traditional staging system.

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“…We recently read the insightful study titled "Predictive value of NLR, Fib4, and APRI in the occurrence of liver failure after hepatectomy in patients with hepatocellular carcinoma" by Kuang et al [ 1 ], which was published in the World Journal of Gastrointestinal Surgery . The study's exploration of neutrophil-lymphocyte ratio (NLR), fibrosis index based on four factors (Fib4), and aspartate aminotransferase-to-platelet ratio index (APRI) as predictive markers for liver failure post-hepatectomy in hepatocellular carcinoma (HCC) patients is commendable.…”

Section: To the Editormentioning

confidence: 99%

Exploring predictive markers for liver failure post-hepatectomy in hepatocellular carcinoma patients

Zhang,

Ma,

Zhu

et al. 2024

World J Gastrointest Surg

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This letter to the editor addresses the study titled “Predictive value of NLR, Fib4, and APRI in the occurrence of liver failure after hepatectomy in patients with hepatocellular carcinoma” by Kuang et al in the World Journal of Gastrointestinal Surgery . The study acknowledges the comprehensive patient data analysis while suggesting that there is a need for further discussion on the clinical applicability of these markers across diverse patient populations. This letter recommends prospective studies for validation and considers the influence of confounding factors. This finding underscores the significance of this study in improving hepatocellular carcinoma management.

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The Clinical Value of Postoperative Transarterial Chemoembolization for Resectable Patients with Intermediate Hepatocellular Carcinoma After Radical Hepatectomy: a Propensity Score-Matching Study

Cited by 8 publications

References 56 publications

Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis

Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis

Pre- and Postoperative Models for Prediction of Recurrence in Non-B, Non-C Hepatocellular Carcinoma

Exploring predictive markers for liver failure post-hepatectomy in hepatocellular carcinoma patients

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