The Clinical Value of Hallucinations in Localizing Brain Tumors

Tarachow, Sidney

doi:10.1176/ajp.97.6.1434

Cited by 19 publications

(3 citation statements)

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“…Our case, along with most reported cases of musical hallucinations, had a right‐sided lesion, which is consistent with current understanding of music processing in the brain 1 . Musical hallucinations have been associated with tumours in the brain stem, the parietal lobe, 10 the temporal lobe 11 and the frontal region 12 . We are unaware of any previous reports of occipital lesions giving rise to musical hallucinations.…”

Section: Discussionmentioning

confidence: 96%

Musical Hallucinations Associated With Recurrence of a Right Occipital Meningioma

Nagaratnam

Virk

Brdarevic

1996

Int J Clinical Practice

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Section: Discussionmentioning

confidence: 96%

Musical Hallucinations Associated With Recurrence of a Right Occipital Meningioma

Nagaratnam

Virk

Brdarevic

1996

Int J Clinical Practice

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“…Particularly important is pathology of either or both temporal lobes 5 . For example, Tarachow 19 reported on 458 patients with supratentorial tumors; of the six with formed hallucinations (not necessarily of music), four had temporal lobe involvement. As Mackworth‐Young 7 reported, the right hemisphere has an important role in music perception, so it may be that right‐sided lesions are more likely to be associated with musical hallucinations.…”

Section: Discussionmentioning

confidence: 99%

Musical Hallucinations

Wengel

Burke

Holemon

1989

J American Geriatrics Society

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Hallucinations may occur in any sensory modality. Auditory hallucinations, usually ascribed to psychiatric illness, take various forms including the perception of voices, cries, noises, or rarely, music. Formed musical hallucinations, (ie, the perception of either vocal or instrumental melodies), reported in the English literature to date have typically been associated with marked hearing loss, advanced age (average 67.8 years), female sex (71%), lack of response to treatment, and general lack of associated psychopathology. We have collected data on seven additional patients with musical hallucinations. The average age of these patients was 72.9 years; all were women. Six had significant hearing problems. All reported onset of musical hallucinations after the age of 60. Interestingly, all seven had major psychiatric illnesses. Four had major depression, two had late-onset schizophrenia, and one had multi-infarct dementia. Of the five who had CT scans, one was normal and the rest demonstrated varying degrees of brain pathology. Neuroleptics were used with varying results in three cases; antidepressants were used in two depressed patients and were temporally related to the onset of musical hallucinations in one patient. Electroconvulsive therapy (ECT) was very effective in treating depression and musical hallucinations in the three patients for whom it was used, usually providing relief from hallucinations after only two treatments. Our collection of cases demonstrates that musical hallucinations can occur in association with psychiatric illness, and perhaps unlike the hallucinations associated with isolated hearing loss, may respond to conventional treatments for the underlying psychiatric disorder. Hearing loss is neither a necessary nor sufficient condition for the occurrence of musical hallucinations.

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“…Rolet et al [9] applied Sniffin Sticks to test the olfactory function in patients with progressive multiple sclerosis (MS), and concluded that MS patients are incapable of discriminating and identifying odors. Tarachow [10] surveyed patients with supratentorial brain tumors and found a high correlation between temporal lobe lesions and olfactory hallucinations. Haehner et al [11] investigated the clinical symptoms in Parkinson's disease (PD) patients and indicated olfactory deficit as an early biomarker preceding motor symptom for diagnosing PDpatients.…”

Section: Introductionmentioning

confidence: 99%

A Multivariate Empirical Mode Decomposition–Based Data-Driven Approach for Extracting Task-Dependent Hemodynamic Responses in Olfactory-Induced fMRI

et al. 2019

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Olfactory dysfunction is related to several clinical neurodegenerative diseases, such as Alzheimer's disease, multiple sclerosis, degenerative ataxias, Parkinson's disease, and so on. Owing to the individual difference in the sensory adaption of human smell function, the olfactory responses usually exhibit large inter-individual difference and change over time after repeated stimulations. The traditional analysis tools, such as statistical parametric mapping (SPM) in functional magnetic resonance imaging technique (fMRI) analysis, utilize the paradigm-based linear correlation and statistical techniques to discriminate the activation areas from background activities. However, these traditional approaches extract olfactory-induced responses using the stereotypic template or paradigm generated model. The olfactory-induced hemodynamic responses affected by internal/external events, such as changes of smell fatigue and attention, are not considered and therefore could result in misleading results. In this paper, owing to the stochastic characteristic of olfactory-induced responses, we adopted multivariate empirical mode decomposition (MEMD) to extract olfactory-induced hemodynamic responses in MRI blood-oxygenlevel dependent (BOLD) signals. The MEMD is an efficient data-driven approach to extract nonlinear and non-stationary signals, which is an improved method to expand traditional empirical mode decomposition (EMD) from one channel to multi-channel processing. We applied MEMD to decompose time series of BOLD signals from each slice into multivariate intrinsic mode functions (IMF). The MEMD enables common features of different scales in an image slice to be arranged in distinct IMFs. Each IMF is an analytic, self-constructed, well-defined, and data-driven function with time-varying frequencies. Each IMF was examined by checking its correlation with the paradigm-generated template. The task-related IMFs were chosen to reconstruct olfactory-induced hemodynamic responses. The group analysis of MEMD-processed data showed olfactory-induced activations in the anterior cingulate cortex and middle frontal gyrus. INDEX TERMS Multivariate empirical mode decomposition, olfactory, functional magnetic resonance imaging.

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The Clinical Value of Hallucinations in Localizing Brain Tumors

Cited by 19 publications

References 0 publications

Musical Hallucinations Associated With Recurrence of a Right Occipital Meningioma

Musical Hallucinations Associated With Recurrence of a Right Occipital Meningioma

Musical Hallucinations

A Multivariate Empirical Mode Decomposition–Based Data-Driven Approach for Extracting Task-Dependent Hemodynamic Responses in Olfactory-Induced fMRI

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